SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cl6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 6cl6 TAIL FIBER PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 393
THR A 379
TRP A 436
GLN A 407
 None
 1.05A 1kglA-6cl6A:
undetectable		 1kglA-6cl6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 6cl6 TAIL FIBER PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 397
ARG A 431
ALA A 405
ILE A 393
 None
 1.22A 1oniH-6cl6A:
undetectable
1oniI-6cl6A:
undetectable		 1oniH-6cl6A:
undetectable
1oniI-6cl6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6cl6 TAIL FIBER PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 SER A 511
ARG A 527
ILE A 484
ASP A 508
 None
 1.11A 4d39A-6cl6A:
undetectable		 4d39A-6cl6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 6cl6 TAIL FIBER PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 517
TRP A 522
ILE A 500
 None
 0.88A 4mwxA-6cl6A:
undetectable		 4mwxA-6cl6A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2O_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 6cl6 TAIL FIBER PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 THR A 600
TRP A 609
ASP A 611
ASN A 612
 None
 1.46A 5b2oA-6cl6A:
0.0		 5b2oA-6cl6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2P_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 6cl6 TAIL FIBER PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 THR A 600
TRP A 609
ASP A 611
ASN A 612
 None
 1.45A 5b2pA-6cl6A:
0.9		 5b2pA-6cl6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1729_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 6cl6 TAIL FIBER PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 THR A 600
TRP A 609
ASP A 611
ASN A 612
 None
 1.46A 5b2qA-6cl6A:
undetectable		 5b2qA-6cl6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 6cl6 TAIL FIBER PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 372
THR A 371
GLY A 403
ALA A 405
LEU A 434
 None
 0.98A 5lf7H-6cl6A:
2.2
5lf7I-6cl6A:
undetectable		 5lf7H-6cl6A:
undetectable
5lf7I-6cl6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 6cl6 TAIL FIBER PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 372
THR A 371
GLY A 403
ALA A 405
LEU A 434
 None
 0.93A 5lf7V-6cl6A:
2.2
5lf7W-6cl6A:
undetectable		 5lf7V-6cl6A:
undetectable
5lf7W-6cl6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		 6cl6 TAIL FIBER PROTEIN
(Pseudomonas
aeruginosa) 		4 / 4 HIS A 491
LEU A 453
TYR A 482
GLY A 488
 None
 1.07A 6n91A-6cl6A:
undetectable		 6n91A-6cl6A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		 6cl6 TAIL FIBER PROTEIN
(Pseudomonas
aeruginosa) 		4 / 4 HIS A 491
LEU A 453
TYR A 482
GLY A 488
 None
 1.08A 6n91B-6cl6A:
undetectable		 6n91B-6cl6A:
21.59