SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cmo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 6cmo CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND RHODOPSIN
(Escherichia
coli;
Homo
sapiens) 		3 / 4 VAL R 129
TRP R 265
TRP R 126
 None
 1.29A 1gmkA-6cmoR:
undetectable
1gmkB-6cmoR:
undetectable		 1gmkA-6cmoR:
undetectable
1gmkB-6cmoR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 6cmo CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND RHODOPSIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 MET R  44
LEU R  47
LEU R  50
GLY R  51
THR R  94
 None
 0.97A 1p93A-6cmoR:
undetectable		 1p93A-6cmoR:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 6cmo CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND RHODOPSIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU R 125
LEU R 128
LEU R 131
ALA R 132
TYR R 306
 None
 0.88A 1s9pC-6cmoR:
undetectable		 1s9pC-6cmoR:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 6cmo CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND RHODOPSIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 TYR R 268
GLU R 181
TYR R 178
GLY R 188
 None
 1.26A 2ha4B-6cmoR:
undetectable		 2ha4B-6cmoR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 6cmo CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND RHODOPSIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 GLY R 121
ALA R 298
ALA R 295
LEU R 119
TRP R 126
 None
 1.08A 3p2kC-6cmoR:
undetectable		 3p2kC-6cmoR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 6cmo CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND RHODOPSIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 TYR R 268
TYR R 191
GLU R 122
 None
 0.88A 3pfgA-6cmoR:
undetectable		 3pfgA-6cmoR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 6cmo CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND RHODOPSIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 ARG R  69
LYS R  67
LYS R  66
 None
 1.32A 4k50A-6cmoR:
undetectable		 4k50A-6cmoR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 6cmo CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND RHODOPSIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 ARG R  69
LYS R  67
LYS R  66
 None
 1.44A 4k50E-6cmoR:
undetectable		 4k50E-6cmoR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 6cmo CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND RHODOPSIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 ARG R  69
LYS R  67
LYS R  66
 None
 1.36A 4k50I-6cmoR:
undetectable		 4k50I-6cmoR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 6cmo CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND RHODOPSIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU R  68
LYS R  67
LEU R  72
ASN R 310
ASN R  73
 None
 1.31A 5kbwA-6cmoR:
2.5		 5kbwA-6cmoR:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 6cmo CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND RHODOPSIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 HIS R 211
GLU R 122
TRP R 126
 None
 1.03A 5odiD-6cmoR:
undetectable		 5odiD-6cmoR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 6cmo CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND RHODOPSIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 HIS R 211
GLU R 122
TRP R 126
 None
 1.13A 5odqD-6cmoR:
undetectable		 5odqD-6cmoR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 6cmo CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND RHODOPSIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 HIS R 211
GLU R 122
TRP R 126
 None
 1.07A 5odrD-6cmoR:
undetectable		 5odrD-6cmoR:
undetectable