SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cmz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		3 / 3 VAL A 396
VAL A 406
TRP A 408
 None
 0.87A 1av2C-6cmzA:
undetectable
1av2D-6cmzA:
undetectable		 1av2C-6cmzA:
undetectable
1av2D-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 ALA A  20
ALA A  21
ALA A 329
VAL A 126
ILE A 137
 None
 0.96A 1fm6U-6cmzA:
undetectable		 1fm6U-6cmzA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 10 GLY A  12
VAL A  34
LEU A   9
LEU A 142
ALA A 118
 FAD  A 502 (-3.2A)
FAD  A 502 (-4.9A)
None
None
FAD  A 502 (-3.4A)
 1.27A 1pbcA-6cmzA:
1.1		 1pbcA-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		3 / 3 VAL A 396
VAL A 406
TRP A 408
 None
 0.86A 1w5uC-6cmzA:
undetectable
1w5uD-6cmzA:
undetectable		 1w5uC-6cmzA:
undetectable
1w5uD-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A 106
GLY A  13
GLY A  17
GLY A 325
LYS A 108
 None
FAD  A 502 ( 4.8A)
None
None
None
 0.98A 1y4lA-6cmzA:
undetectable		 1y4lA-6cmzA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 5 LEU A 190
LEU A 178
LEU A 174
LEU A 266
 None
 1.01A 1yajD-6cmzA:
undetectable		 1yajD-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A 317
GLY A 313
ASP A 310
ALA A 312
ALA A 307
 FAD  A 502 (-3.8A)
None
FAD  A 502 (-2.9A)
None
None
 1.22A 2br4B-6cmzA:
2.9		 2br4B-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 ALA A 389
ALA A 384
LEU A 445
ALA A 448
VAL A 415
 None
 1.07A 2bxeB-6cmzA:
3.2		 2bxeB-6cmzA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 GLY A 147
THR A 146
THR A  42
ARG A  36
GLY A  14
 FAD  A 502 (-3.0A)
FAD  A 502 (-4.2A)
FAD  A 502 (-3.5A)
FAD  A 502 (-3.4A)
FAD  A 502 (-3.3A)
 1.17A 2fn1B-6cmzA:
undetectable		 2fn1B-6cmzA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		3 / 3 VAL A 406
TRP A 408
VAL A 396
 None
 0.92A 2izqA-6cmzA:
undetectable
2izqB-6cmzA:
undetectable		 2izqA-6cmzA:
undetectable
2izqB-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 5 LEU A 454
ALA A 452
TRP A 408
LEU A 449
 None
 1.25A 2oaxA-6cmzA:
undetectable		 2oaxA-6cmzA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 7 ILE A  11
LEU A 143
GLY A  16
GLY A  13
THR A 146
 FAD  A 502 ( 4.9A)
None
FAD  A 502 (-3.7A)
FAD  A 502 ( 4.8A)
FAD  A 502 (-4.2A)
 1.43A 2wd9A-6cmzA:
undetectable		 2wd9A-6cmzA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 8 ILE A  11
LEU A 143
GLY A  16
GLY A  13
THR A 146
 FAD  A 502 ( 4.9A)
None
FAD  A 502 (-3.7A)
FAD  A 502 ( 4.8A)
FAD  A 502 (-4.2A)
 1.39A 2wd9B-6cmzA:
undetectable		 2wd9B-6cmzA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 7 VAL A 111
GLY A  25
ALA A  24
LEU A   8
 None
 0.92A 2wekB-6cmzA:
2.8		 2wekB-6cmzA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 6 THR A 300
ARG A 320
LEU A 144
ASP A 310
 None
None
None
FAD  A 502 (-2.9A)
 1.12A 2wm3A-6cmzA:
4.0		 2wm3A-6cmzA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 LEU A 197
VAL A 193
GLY A 191
VAL A 201
ILE A  84
 None
 1.14A 2yy8A-6cmzA:
4.0
2yy8B-6cmzA:
3.7		 2yy8A-6cmzA:
undetectable
2yy8B-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 VAL A 239
LEU A 240
GLY A 241
LYS A 244
THR A 259
 FAD  A 503 (-4.1A)
None
None
None
None
 1.24A 3bjwB-6cmzA:
undetectable		 3bjwB-6cmzA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 VAL A 239
LEU A 240
GLY A 241
LYS A 244
THR A 259
 FAD  A 503 (-4.1A)
None
None
None
None
 1.28A 3bjwE-6cmzA:
undetectable		 3bjwE-6cmzA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 VAL A 239
LEU A 240
GLY A 241
LYS A 244
THR A 259
 FAD  A 503 (-4.1A)
None
None
None
None
 1.23A 3bjwF-6cmzA:
undetectable		 3bjwF-6cmzA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 VAL A 239
LEU A 240
GLY A 241
LYS A 244
THR A 259
 FAD  A 503 (-4.1A)
None
None
None
None
 1.20A 3bjwH-6cmzA:
undetectable		 3bjwH-6cmzA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 ALA A  20
ALA A  21
ALA A 329
VAL A 126
ILE A 137
 None
 0.97A 3e00A-6cmzA:
undetectable		 3e00A-6cmzA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 10 ALA A  20
ALA A  21
ALA A 329
VAL A 126
ILE A 137
 None
 1.03A 3falA-6cmzA:
undetectable		 3falA-6cmzA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 ALA A  20
ALA A  21
ALA A 329
VAL A 126
ILE A 137
 None
 1.01A 3h0aA-6cmzA:
undetectable		 3h0aA-6cmzA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 10 LYS A 196
LEU A 229
ILE A 192
SER A 202
GLY A 191
 None
 1.21A 3ijxB-6cmzA:
undetectable
3ijxD-6cmzA:
undetectable		 3ijxB-6cmzA:
18.55
3ijxD-6cmzA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 10 ILE A 192
SER A 202
GLY A 191
LYS A 196
LEU A 229
 None
 1.20A 3ik6B-6cmzA:
undetectable
3ik6E-6cmzA:
undetectable		 3ik6B-6cmzA:
18.55
3ik6E-6cmzA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 10 LYS A 196
LEU A 229
ILE A 192
SER A 202
GLY A 191
 None
 1.18A 3ik6B-6cmzA:
undetectable
3ik6E-6cmzA:
undetectable		 3ik6B-6cmzA:
18.55
3ik6E-6cmzA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 10 LYS A 196
LEU A 229
ILE A 192
SER A 202
GLY A 191
 None
 1.22A 3iluB-6cmzA:
undetectable
3iluE-6cmzA:
undetectable		 3iluB-6cmzA:
18.55
3iluE-6cmzA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 ILE A 192
SER A 202
GLY A 191
LYS A 196
LEU A 229
 None
 1.19A 3iluB-6cmzA:
undetectable
3iluE-6cmzA:
undetectable		 3iluB-6cmzA:
18.55
3iluE-6cmzA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		3 / 3 VAL A 396
VAL A 406
TRP A 408
 None
 0.91A 3l8lC-6cmzA:
undetectable
3l8lD-6cmzA:
undetectable		 3l8lC-6cmzA:
undetectable
3l8lD-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		3 / 3 ILE A 137
VAL A  32
ARG A 112
 None
 0.76A 3p73A-6cmzA:
undetectable		 3p73A-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 11 ALA A 145
VAL A  10
ALA A 323
LEU A  33
LEU A 143
 FAD  A 502 (-4.8A)
None
None
None
None
 1.03A 3sm2B-6cmzA:
undetectable		 3sm2B-6cmzA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 VAL A 126
THR A   6
THR A   7
ILE A  29
VAL A  34
 None
None
None
None
FAD  A 502 (-4.9A)
 1.14A 3sp9B-6cmzA:
undetectable		 3sp9B-6cmzA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 ALA A  20
ALA A  21
ALA A 329
VAL A 126
ILE A 137
 None
 0.99A 3uvvB-6cmzA:
undetectable		 3uvvB-6cmzA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 7 ARG A 320
ALA A 321
ILE A 308
GLY A 147
 None
FAD  A 502 ( 4.0A)
None
FAD  A 502 (-3.0A)
 1.00A 3v4tH-6cmzA:
undetectable		 3v4tH-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A 266
GLY A 191
ILE A  55
VAL A 193
ALA A 183
 None
 1.15A 4a6dA-6cmzA:
undetectable		 4a6dA-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A 266
GLY A 191
ILE A  55
VAL A 193
ALA A 183
 None
 1.12A 4a6eA-6cmzA:
2.8		 4a6eA-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 6 ARG A 399
HIS A 403
LEU A 372
ASP A 401
 None
 1.39A 4cevA-6cmzA:
undetectable
4cevB-6cmzA:
undetectable		 4cevA-6cmzA:
undetectable
4cevB-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 6 ASP A 401
ARG A 399
HIS A 403
LEU A 372
 None
 1.41A 4cevA-6cmzA:
undetectable
4cevC-6cmzA:
undetectable		 4cevA-6cmzA:
undetectable
4cevC-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 6 ARG A 399
HIS A 403
LEU A 372
ASP A 401
 None
 1.39A 4cevD-6cmzA:
undetectable
4cevE-6cmzA:
undetectable		 4cevD-6cmzA:
undetectable
4cevE-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 6 ARG A 399
HIS A 403
LEU A 372
ASP A 401
 None
 1.40A 4cevE-6cmzA:
undetectable
4cevF-6cmzA:
undetectable		 4cevE-6cmzA:
undetectable
4cevF-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 8 GLY A  25
LEU A  27
ILE A  29
THR A  31
 None
 0.86A 4em2A-6cmzA:
undetectable		 4em2A-6cmzA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A 426
ILE A 405
ALA A 398
ALA A 364
GLY A 368
 None
 0.98A 4enhA-6cmzA:
undetectable		 4enhA-6cmzA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 ALA A 333
GLY A  25
GLN A  26
ALA A 323
GLY A 325
 None
 1.31A 4r29A-6cmzA:
undetectable		 4r29A-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  16
GLY A  17
GLY A  40
ILE A  49
SER A  51
 FAD  A 502 (-3.7A)
None
None
None
FAD  A 502 (-3.6A)
 1.05A 4rtmA-6cmzA:
2.5		 4rtmA-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 5 PRO A 150
VAL A 151
ALA A 268
PHE A 158
 None
FAD  A 503 (-4.8A)
None
None
 0.74A 4w5oA-6cmzA:
undetectable		 4w5oA-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 5 PRO A 150
VAL A 151
ALA A 268
PHE A 158
 None
FAD  A 503 (-4.8A)
None
None
 0.74A 4z4cA-6cmzA:
undetectable		 4z4cA-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 5 PRO A 150
VAL A 151
ALA A 268
PHE A 158
 None
FAD  A 503 (-4.8A)
None
None
 0.73A 4z4dA-6cmzA:
undetectable		 4z4dA-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 5 PRO A 150
VAL A 151
ALA A 268
PHE A 158
 None
FAD  A 503 (-4.8A)
None
None
 0.74A 4z4eA-6cmzA:
undetectable		 4z4eA-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		3 / 3 VAL A 151
ALA A 268
PHE A 158
 FAD  A 503 (-4.8A)
None
None
 0.61A 4z4iA-6cmzA:
undetectable		 4z4iA-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 ILE A 354
GLY A 412
ALA A 419
SER A  51
ILE A  55
 None
None
None
FAD  A 502 (-3.6A)
None
 1.01A 5igyA-6cmzA:
undetectable		 5igyA-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		3 / 3 VAL A 151
ALA A 268
PHE A 158
 FAD  A 503 (-4.8A)
None
None
 0.60A 5js1A-6cmzA:
undetectable		 5js1A-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 5 GLU A 117
GLY A  12
ARG A 274
GLY A 147
 FAD  A 502 (-3.3A)
FAD  A 502 (-3.2A)
FAD  A 502 (-4.1A)
FAD  A 502 (-3.0A)
 1.09A 5kprA-6cmzA:
undetectable		 5kprA-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 6 PRO A 150
VAL A 151
ALA A 268
PHE A 158
 None
FAD  A 503 (-4.8A)
None
None
 0.70A 5t7bA-6cmzA:
undetectable		 5t7bA-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		3 / 3 MET A 316
GLU A 149
ARG A 271
 None
None
FAD  A 502 (-3.8A)
 0.89A 5tjyA-6cmzA:
3.2		 5tjyA-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		3 / 3 MET A 316
GLU A 149
ARG A 271
 None
None
FAD  A 502 (-3.8A)
 0.86A 5tjzA-6cmzA:
3.3		 5tjzA-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A 142
PHE A 278
VAL A 126
THR A  42
GLY A  41
 None
FAD  A 502 (-4.2A)
None
FAD  A 502 (-3.5A)
FAD  A 502 (-3.2A)
 1.28A 5xipA-6cmzA:
3.2		 5xipA-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 7 THR A 350
LEU A 188
ILE A 186
TYR A 214
 None
None
FAD  A 502 (-4.0A)
None
 0.87A 5zsfA-6cmzA:
undetectable
5zsfB-6cmzA:
undetectable		 5zsfA-6cmzA:
27.91
5zsfB-6cmzA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 10 GLY A  13
GLY A  41
GLU A  35
ASP A  37
ILE A  11
 FAD  A 502 ( 4.8A)
FAD  A 502 (-3.2A)
FAD  A 502 (-2.5A)
None
FAD  A 502 ( 4.9A)
 1.03A 6exiA-6cmzA:
3.3		 6exiA-6cmzA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 10 GLY A  13
GLY A  41
GLU A  35
ASP A  37
ILE A  11
 FAD  A 502 ( 4.8A)
FAD  A 502 (-3.2A)
FAD  A 502 (-2.5A)
None
FAD  A 502 ( 4.9A)
 1.03A 6exiB-6cmzA:
3.2		 6exiB-6cmzA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  13
GLY A  41
GLU A  35
ASP A  37
ILE A  11
 FAD  A 502 ( 4.8A)
FAD  A 502 (-3.2A)
FAD  A 502 (-2.5A)
None
FAD  A 502 ( 4.9A)
 1.03A 6exiC-6cmzA:
3.2
6exiD-6cmzA:
3.7		 6exiC-6cmzA:
24.14
6exiD-6cmzA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  13
GLY A  41
GLU A  35
ASP A  37
ILE A  11
 FAD  A 502 ( 4.8A)
FAD  A 502 (-3.2A)
FAD  A 502 (-2.5A)
None
FAD  A 502 ( 4.9A)
 1.05A 6exiC-6cmzA:
3.2
6exiD-6cmzA:
3.7		 6exiC-6cmzA:
24.14
6exiD-6cmzA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 6cmz DIHYDROLIPOYL
DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 7 ALA A 448
GLY A 446
GLY A 412
ASN A 381
 None
 0.82A 6nm4A-6cmzA:
undetectable		 6nm4A-6cmzA:
undetectable