SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cn0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE
(Proteus
mirabilis) 		4 / 8 PHE A 253
TYR A 206
ILE A 231
LEU A 257
 None
 0.86A 1fslB-6cn0A:
undetectable		 1fslB-6cn0A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE
(Proteus
mirabilis) 		4 / 6 LYS A 267
VAL A 258
ILE A 264
MET A 202
 None
 0.99A 1iepA-6cn0A:
undetectable		 1iepA-6cn0A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE
(Proteus
mirabilis) 		5 / 12 HIS A 171
ILE A  73
ILE A  77
ALA A 178
GLU A  70
 None
 1.01A 1ki7B-6cn0A:
undetectable		 1ki7B-6cn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE
(Proteus
mirabilis) 		5 / 12 ILE A  64
LEU A 139
GLY A  62
GLY A  63
LEU A  69
 None
 1.07A 1liiA-6cn0A:
undetectable		 1liiA-6cn0A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE
(Proteus
mirabilis) 		4 / 5 LYS A 267
VAL A 258
ILE A 264
MET A 202
 None
 0.98A 1opjA-6cn0A:
1.0		 1opjA-6cn0A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE
(Proteus
mirabilis) 		4 / 6 LYS A 267
VAL A 258
ILE A 264
MET A 202
 None
 1.02A 1opjB-6cn0A:
undetectable		 1opjB-6cn0A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE
(Proteus
mirabilis) 		4 / 6 LYS A 267
VAL A 258
ILE A 264
MET A 202
 None
 1.03A 2hyyC-6cn0A:
undetectable		 2hyyC-6cn0A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE
(Proteus
mirabilis) 		4 / 6 TYR A 119
PHE A 147
ASP A 134
TYR A 156
 None
 1.47A 2todA-6cn0A:
undetectable
2todB-6cn0A:
undetectable		 2todA-6cn0A:
11.93
2todB-6cn0A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE
(Proteus
mirabilis) 		5 / 12 ASP A 134
GLY A 136
ASP A 160
LEU A 205
LEU A 209
 None
 0.58A 3cjtC-6cn0A:
10.6		 3cjtC-6cn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE
(Proteus
mirabilis) 		5 / 12 GLY A 136
ALA A 135
ASP A 134
VAL A 230
ILE A 189
 None
 0.89A 3ekqA-6cn0A:
undetectable		 3ekqA-6cn0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE
(Proteus
mirabilis) 		4 / 5 LYS A 267
VAL A 258
ILE A 264
MET A 202
 None
 1.01A 3gvuA-6cn0A:
undetectable		 3gvuA-6cn0A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE
(Proteus
mirabilis) 		3 / 3 GLU A  74
HIS A 171
THR A 175
 None
 0.80A 3hkuA-6cn0A:
undetectable		 3hkuA-6cn0A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE
(Proteus
mirabilis) 		3 / 3 ARG A 111
ASP A 160
GLN A 212
 None
 0.72A 3lcvB-6cn0A:
26.0		 3lcvB-6cn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE
(Proteus
mirabilis) 		4 / 6 LYS A 267
VAL A 258
ILE A 264
MET A 202
 None
 1.01A 3ms9A-6cn0A:
undetectable		 3ms9A-6cn0A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE
(Proteus
mirabilis) 		4 / 5 LYS A 267
VAL A 258
ILE A 264
MET A 202
 None
 1.11A 3oezA-6cn0A:
1.6		 3oezA-6cn0A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE
(Proteus
mirabilis) 		4 / 5 LYS A 267
VAL A 258
ILE A 264
MET A 202
 None
 0.98A 3pyyB-6cn0A:
undetectable		 3pyyB-6cn0A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE
(Proteus
mirabilis) 		3 / 3 TYR A 249
LEU A 268
LYS A 269
 None
 0.77A 3sueD-6cn0A:
undetectable		 3sueD-6cn0A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE
(Proteus
mirabilis) 		4 / 5 TYR A  60
ASP A 160
ASP A 188
ILE A 189
 None
 1.16A 3uj7B-6cn0A:
11.9		 3uj7B-6cn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE
(Proteus
mirabilis) 		5 / 12 GLU A 273
LEU A 102
ASP A 134
LEU A 201
TYR A 156
 None
 1.19A 4foxB-6cn0A:
undetectable		 4foxB-6cn0A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE
(Proteus
mirabilis) 		5 / 12 HIS A 171
SER A 172
ILE A  73
ASP A  65
GLY A  66
 None
 1.17A 4foxB-6cn0A:
undetectable		 4foxB-6cn0A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE
(Proteus
mirabilis) 		5 / 11 GLU A 273
LEU A 102
ASP A 134
LEU A 201
TYR A 156
 None
 1.22A 4foxC-6cn0A:
undetectable		 4foxC-6cn0A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE
(Proteus
mirabilis) 		5 / 12 GLU A 273
LEU A 102
ASP A 134
LEU A 201
TYR A 156
 None
 1.17A 4foxG-6cn0A:
undetectable		 4foxG-6cn0A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE
(Proteus
mirabilis) 		5 / 11 ALA A 215
GLU A 223
LEU A 221
LEU A 262
LEU A 257
 None
 1.17A 4wg0G-6cn0A:
undetectable
4wg0H-6cn0A:
undetectable
4wg0I-6cn0A:
undetectable		 4wg0G-6cn0A:
undetectable
4wg0H-6cn0A:
undetectable
4wg0I-6cn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE
(Proteus
mirabilis) 		5 / 9 ILE A 169
ALA A 138
ASP A 160
LYS A 185
ILE A 132
 None
 1.49A 5z6lA-6cn0A:
undetectable		 5z6lA-6cn0A:
undetectable