SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cn7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 6cn7 AEROBACTIN SYNTHASE
IUCC
(Klebsiella
pneumoniae) 		5 / 12 GLU A 394
ASP A 392
ARG A 505
ASP A 516
THR A 395
 None
 1.46A 1s14A-6cn7A:
undetectable		 1s14A-6cn7A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 6cn7 AEROBACTIN SYNTHASE
IUCC
(Klebsiella
pneumoniae) 		5 / 12 GLN A 436
PHE A 401
LEU A 397
HIS A 484
ALA A 429
 None
 1.27A 2g70A-6cn7A:
undetectable		 2g70A-6cn7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 6cn7 AEROBACTIN SYNTHASE
IUCC
(Klebsiella
pneumoniae) 		5 / 12 GLN A 436
PHE A 401
LEU A 397
HIS A 484
ALA A 429
 None
 1.25A 2g70B-6cn7A:
undetectable		 2g70B-6cn7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 6cn7 AEROBACTIN SYNTHASE
IUCC
(Klebsiella
pneumoniae) 		5 / 12 GLN A 436
PHE A 401
LEU A 397
HIS A 484
ALA A 429
 None
 1.24A 2g72B-6cn7A:
undetectable		 2g72B-6cn7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 6cn7 AEROBACTIN SYNTHASE
IUCC
(Klebsiella
pneumoniae) 		4 / 6 ARG A 352
ASP A 271
THR A 260
ASP A 442
 None
 1.15A 2j2pE-6cn7A:
undetectable
2j2pF-6cn7A:
undetectable		 2j2pE-6cn7A:
16.67
2j2pF-6cn7A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 6cn7 AEROBACTIN SYNTHASE
IUCC
(Klebsiella
pneumoniae) 		5 / 12 GLU A 394
ASP A 392
ARG A 505
ASP A 516
THR A 395
 None
 1.41A 3lpsA-6cn7A:
undetectable		 3lpsA-6cn7A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 6cn7 AEROBACTIN SYNTHASE
IUCC
(Klebsiella
pneumoniae) 		4 / 7 LEU A 471
ARG A 470
THR A 468
ALA A 469
 None
 1.29A 3mbgA-6cn7A:
undetectable
3mbgB-6cn7A:
undetectable		 3mbgA-6cn7A:
undetectable
3mbgB-6cn7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 6cn7 AEROBACTIN SYNTHASE
IUCC
(Klebsiella
pneumoniae) 		4 / 5 GLY A 383
ASP A 387
ARG A 388
GLN A 399
 None
None
MES  A 600 (-4.7A)
None
 1.47A 3qx3A-6cn7A:
undetectable		 3qx3A-6cn7A:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 6cn7 AEROBACTIN SYNTHASE
IUCC
(Klebsiella
pneumoniae) 		3 / 3 ARG A 527
PRO A 522
PHE A 528
 None
 1.04A 3thrC-6cn7A:
undetectable		 3thrC-6cn7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 6cn7 AEROBACTIN SYNTHASE
IUCC
(Klebsiella
pneumoniae) 		4 / 8 TRP A  46
PHE A  27
VAL A  26
LEU A  77
 None
 1.21A 4f5zA-6cn7A:
undetectable		 4f5zA-6cn7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 6cn7 AEROBACTIN SYNTHASE
IUCC
(Klebsiella
pneumoniae) 		3 / 3 GLN A 399
THR A 398
THR A 395
 None
 0.78A 4fu9A-6cn7A:
undetectable		 4fu9A-6cn7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 6cn7 AEROBACTIN SYNTHASE
IUCC
(Klebsiella
pneumoniae) 		3 / 3 GLN A 399
THR A 398
THR A 395
 None
 0.77A 4fufA-6cn7A:
undetectable		 4fufA-6cn7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 6cn7 AEROBACTIN SYNTHASE
IUCC
(Klebsiella
pneumoniae) 		5 / 11 LEU A 548
LEU A  21
LEU A  78
VAL A  84
LEU A  41
 None
 1.11A 4p65C-6cn7A:
undetectable
4p65D-6cn7A:
undetectable
4p65J-6cn7A:
undetectable
4p65L-6cn7A:
undetectable		 4p65C-6cn7A:
undetectable
4p65D-6cn7A:
undetectable
4p65J-6cn7A:
undetectable
4p65L-6cn7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 6cn7 AEROBACTIN SYNTHASE
IUCC
(Klebsiella
pneumoniae) 		5 / 11 LEU A  78
VAL A  84
LEU A  41
LEU A 548
LEU A  21
 None
 1.17A 4p65B-6cn7A:
undetectable
4p65D-6cn7A:
undetectable
4p65G-6cn7A:
undetectable
4p65H-6cn7A:
undetectable		 4p65B-6cn7A:
undetectable
4p65D-6cn7A:
undetectable
4p65G-6cn7A:
undetectable
4p65H-6cn7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 6cn7 AEROBACTIN SYNTHASE
IUCC
(Klebsiella
pneumoniae) 		5 / 11 ASP A 271
GLN A 255
ALA A 254
PRO A 158
ASP A 442
 None
 1.29A 4uuuB-6cn7A:
undetectable		 4uuuB-6cn7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 6cn7 AEROBACTIN SYNTHASE
IUCC
(Klebsiella
pneumoniae) 		5 / 12 ALA A 140
LEU A  13
ILE A  39
LEU A  65
LEU A  81
 None
 1.02A 5toaA-6cn7A:
undetectable		 5toaA-6cn7A:
14.11