SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cnh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		4 / 6 THR A 952
LEU A 904
GLY A 906
LYS A 899
 None
 1.05A 1gtiC-6cnhA:
undetectable		 1gtiC-6cnhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		4 / 5 THR A 952
LEU A 904
GLY A 906
LYS A 899
 None
 1.07A 1gtiF-6cnhA:
undetectable		 1gtiF-6cnhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		4 / 4 VAL A 701
ALA A 715
LEU A 751
PHE A 767
 919  A1101 (-4.7A)
919  A1101 (-3.5A)
919  A1101 (-4.5A)
919  A1101 (-3.8A)
 0.34A 1q97B-6cnhA:
31.4		 1q97B-6cnhA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		6 / 12 ALA A 715
GLU A 732
LEU A 736
LEU A 751
LEU A 806
HIS A 813
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
None
919  A1101 (-4.5A)
None
919  A1101 (-4.2A)
 0.73A 1uwhA-6cnhA:
21.8		 1uwhA-6cnhA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		7 / 12 ALA A 715
LYS A 717
GLU A 732
LEU A 736
LEU A 751
LEU A 806
HIS A 813
 919  A1101 (-3.5A)
SO4  A1102 ( 2.8A)
919  A1101 (-3.7A)
None
919  A1101 (-4.5A)
None
919  A1101 (-4.2A)
 0.75A 1uwhB-6cnhA:
21.7		 1uwhB-6cnhA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 ILE A 718
VAL A 677
VAL A 716
ALA A 715
LEU A 683
 None
None
None
919  A1101 (-3.5A)
None
 1.03A 1vptA-6cnhA:
undetectable		 1vptA-6cnhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 GLY A 876
VAL A 792
LEU A 979
LEU A 976
LEU A 803
 None
 1.31A 1ya4B-6cnhA:
undetectable		 1ya4B-6cnhA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 ALA A 802
LEU A 830
PHE A 800
THR A 878
LEU A 979
 None
 1.19A 2oipC-6cnhA:
undetectable		 2oipC-6cnhA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 ALA A 802
LEU A 830
PHE A 800
THR A 878
LEU A 979
 None
 1.16A 2oipD-6cnhA:
undetectable		 2oipD-6cnhA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		4 / 7 PRO A 858
ALA A 901
LEU A 898
PHE A 923
 None
 0.83A 2vcvA-6cnhA:
undetectable		 2vcvA-6cnhA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		4 / 7 PRO A 858
ALA A 901
LEU A 898
PHE A 923
 None
 0.80A 2vcvG-6cnhA:
1.2		 2vcvG-6cnhA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		4 / 8 ASN A 700
SER A 699
VAL A 702
PHE A 767
 None
SO4  A1102 (-2.6A)
None
919  A1101 (-3.8A)
 1.14A 2wekA-6cnhA:
undetectable		 2wekA-6cnhA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		4 / 8 ASN A 700
SER A 699
VAL A 702
PHE A 767
 None
SO4  A1102 (-2.6A)
None
919  A1101 (-3.8A)
 1.15A 2wekB-6cnhA:
undetectable		 2wekB-6cnhA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		3 / 3 CYH A 750
HIS A 749
PHE A 748
 919  A1101 ( 4.4A)
None
None
 1.21A 3cr4X-6cnhA:
undetectable		 3cr4X-6cnhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 ALA A 715
GLU A 732
HIS A 813
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
919  A1101 (-4.2A)
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.58A 3cs9B-6cnhA:
21.9		 3cs9B-6cnhA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL A 701
LYS A 717
LEU A 822
ASP A 834
 919  A1101 (-4.7A)
SO4  A1102 ( 2.8A)
None
919  A1101 (-4.5A)
 0.59A 3cs9D-6cnhA:
20.5		 3cs9D-6cnhA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 ALA A 715
GLU A 732
LEU A 736
HIS A 813
ASP A 834
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
None
919  A1101 (-4.2A)
919  A1101 (-4.5A)
 0.82A 3gcsA-6cnhA:
25.5		 3gcsA-6cnhA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 VAL A 701
ALA A 715
LEU A 736
HIS A 813
ASP A 834
 919  A1101 (-4.7A)
919  A1101 (-3.5A)
None
919  A1101 (-4.2A)
919  A1101 (-4.5A)
 0.72A 3gcsA-6cnhA:
25.5		 3gcsA-6cnhA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		6 / 12 VAL A 701
ALA A 715
GLU A 732
LEU A 736
HIS A 813
ASP A 834
 919  A1101 (-4.7A)
919  A1101 (-3.5A)
919  A1101 (-3.7A)
None
919  A1101 (-4.2A)
919  A1101 (-4.5A)
 0.70A 3gp0A-6cnhA:
26.9		 3gp0A-6cnhA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		6 / 12 VAL A 701
ALA A 715
LYS A 717
GLU A 732
LEU A 736
ASP A 834
 919  A1101 (-4.7A)
919  A1101 (-3.5A)
SO4  A1102 ( 2.8A)
919  A1101 (-3.7A)
None
919  A1101 (-4.5A)
 0.93A 3hegA-6cnhA:
26.2		 3hegA-6cnhA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 ALA A 715
GLU A 732
HIS A 813
LEU A 822
ASP A 834
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
 0.54A 3ik3A-6cnhA:
21.5		 3ik3A-6cnhA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 GLU A 732
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.7A)
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.46A 3ik3A-6cnhA:
21.5		 3ik3A-6cnhA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 ALA A 715
GLU A 732
HIS A 813
LEU A 822
ASP A 834
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
 0.49A 3ik3B-6cnhA:
21.2		 3ik3B-6cnhA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 GLU A 732
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.7A)
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.42A 3ik3B-6cnhA:
21.2		 3ik3B-6cnhA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		7 / 12 VAL A 701
ALA A 715
GLU A 732
LEU A 736
PHE A 767
LEU A 806
HIS A 813
 919  A1101 (-4.7A)
919  A1101 (-3.5A)
919  A1101 (-3.7A)
None
919  A1101 (-3.8A)
None
919  A1101 (-4.2A)
 0.57A 3rgfA-6cnhA:
11.7		 3rgfA-6cnhA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		7 / 12 ALA A 715
GLU A 732
LEU A 806
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
None
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.69A 3zosA-6cnhA:
21.1		 3zosA-6cnhA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		7 / 12 ALA A 715
GLU A 732
LEU A 806
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
None
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.69A 3zosB-6cnhA:
2.3		 3zosB-6cnhA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		9 / 12 ALA A 715
LYS A 717
GLU A 732
LEU A 736
LEU A 751
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
SO4  A1102 ( 2.8A)
919  A1101 (-3.7A)
None
919  A1101 (-4.5A)
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.78A 4c8bA-6cnhA:
22.2		 4c8bA-6cnhA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		9 / 12 ALA A 715
LYS A 717
GLU A 732
LEU A 736
LEU A 751
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
SO4  A1102 ( 2.8A)
919  A1101 (-3.7A)
None
919  A1101 (-4.5A)
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.71A 4c8bB-6cnhA:
22.0		 4c8bB-6cnhA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 LEU A 733
LEU A 730
GLY A 729
GLN A 726
VAL A 701
 None
None
None
None
919  A1101 (-4.7A)
 0.81A 4ok1A-6cnhA:
undetectable		 4ok1A-6cnhA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		3 / 3 ASP A 743
LYS A 804
LEU A 998
 None
 1.01A 4ptjA-6cnhA:
undetectable		 4ptjA-6cnhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		6 / 12 ALA A 715
GLU A 732
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.55A 4tyjA-6cnhA:
22.0		 4tyjA-6cnhA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		7 / 12 ALA A 715
LEU A 736
HIS A 813
LEU A 822
CYH A 833
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
None
919  A1101 (-4.2A)
None
919  A1101 (-4.1A)
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.83A 4u0iA-6cnhA:
21.4		 4u0iA-6cnhA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		6 / 12 ALA A 715
GLU A 732
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.62A 4uxqA-6cnhA:
22.0		 4uxqA-6cnhA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		6 / 12 GLU A 732
LEU A 806
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.7A)
None
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.72A 4uxqA-6cnhA:
22.0		 4uxqA-6cnhA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 ALA A 715
GLU A 732
HIS A 813
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
919  A1101 (-4.2A)
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.50A 4v01A-6cnhA:
21.7		 4v01A-6cnhA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 GLU A 732
LEU A 806
HIS A 813
ASP A 834
PHE A 835
 919  A1101 (-3.7A)
None
919  A1101 (-4.2A)
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.62A 4v01A-6cnhA:
21.7		 4v01A-6cnhA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 ALA A 715
GLU A 732
HIS A 813
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
919  A1101 (-4.2A)
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.58A 4v01B-6cnhA:
22.1		 4v01B-6cnhA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 GLU A 732
LEU A 806
HIS A 813
ASP A 834
PHE A 835
 919  A1101 (-3.7A)
None
919  A1101 (-4.2A)
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.59A 4v01B-6cnhA:
22.1		 4v01B-6cnhA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 ALA A 715
GLU A 732
HIS A 813
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
919  A1101 (-4.2A)
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.61A 4v04B-6cnhA:
21.8		 4v04B-6cnhA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 GLU A 732
LEU A 806
HIS A 813
ASP A 834
PHE A 835
 919  A1101 (-3.7A)
None
919  A1101 (-4.2A)
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.73A 4v04B-6cnhA:
21.8		 4v04B-6cnhA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		3 / 3 MET A 985
ASP A 978
PHE A1002
 None
 1.01A 4xeyA-6cnhA:
21.0		 4xeyA-6cnhA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		3 / 3 MET A 985
ASP A 978
PHE A1002
 None
 1.02A 4xeyB-6cnhA:
20.6		 4xeyB-6cnhA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EVY_X_SALX502_1
(SALICYLATE
HYDROXYLASE)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		4 / 5 SER A 865
MET A 656
LEU A 812
PHE A 658
 None
 1.29A 5evyX-6cnhA:
undetectable		 5evyX-6cnhA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		6 / 12 ALA A 715
LYS A 717
GLU A 732
LEU A 736
LEU A 751
HIS A 813
 919  A1101 (-3.5A)
SO4  A1102 ( 2.8A)
919  A1101 (-3.7A)
None
919  A1101 (-4.5A)
919  A1101 (-4.2A)
 0.61A 5hi2A-6cnhA:
21.4		 5hi2A-6cnhA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		6 / 12 LYS A 717
GLU A 732
LEU A 736
LEU A 751
LEU A 806
HIS A 813
 SO4  A1102 ( 2.8A)
919  A1101 (-3.7A)
None
919  A1101 (-4.5A)
None
919  A1101 (-4.2A)
 0.61A 5hi2A-6cnhA:
21.4		 5hi2A-6cnhA:
14.55