SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cnk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M9J_B_CLWB907_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 6cnk IGG1 HEAVY CHAIN
IGG1 KAPPA LIGHT
CHAIN
(Mus
musculus) 		4 / 5 PRO G 102
VAL F  99
TYR G 100
GLU G  36
 None
 1.50A 1m9jB-6cnkG:
undetectable		 1m9jB-6cnkG:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 6cnk IGG1 KAPPA LIGHT
CHAIN
IGG1 HEAVY CHAIN
(Mus
musculus;
Mus
musculus) 		3 / 3 ASP F   1
GLU G  51
TYR G 103
 None
 0.82A 1wsvA-6cnkF:
undetectable		 1wsvA-6cnkF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 6cnk IGG1 KAPPA LIGHT
CHAIN
IGG1 HEAVY CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 7 TYR F  41
PRO F  49
TYR F  92
TYR G  96
 None
 0.64A 2oldA-6cnkF:
15.7
2oldB-6cnkF:
18.9		 2oldA-6cnkF:
undetectable
2oldB-6cnkF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 6cnk IGG1 KAPPA LIGHT
CHAIN
IGG1 HEAVY CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 7 TYR G  96
TYR F  41
PRO F  49
TYR F  92
 None
 0.68A 2oldA-6cnkG:
12.0
2oldB-6cnkG:
15.4		 2oldA-6cnkG:
undetectable
2oldB-6cnkG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6cnk IGG1 KAPPA LIGHT
CHAIN
IGG1 HEAVY CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 7 ILE G  21
PRO F  49
GLY G 111
TRP G 110
 None
 1.20A 2pnjB-6cnkG:
undetectable		 2pnjB-6cnkG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 6cnk IGG1 HEAVY CHAIN
IGG1 KAPPA LIGHT
CHAIN
(Mus
musculus) 		4 / 7 PHE F 103
ASN G  62
GLY G  50
PHE F  94
 None
 1.00A 4ejjB-6cnkF:
undetectable		 4ejjB-6cnkF:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 6cnk IGG1 KAPPA LIGHT
CHAIN
IGG1 HEAVY CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 5 GLY G 134
SER G 135
ALA G 136
PHE F 214
 None
 0.71A 4m93B-6cnkG:
21.7
4m93C-6cnkG:
16.4		 4m93B-6cnkG:
undetectable
4m93C-6cnkG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 6cnk IGG1 HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER G 210
ALA G 205
VAL G 204
 None
 0.62A 4o2bA-6cnkG:
undetectable		 4o2bA-6cnkG:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 6cnk IGG1 HEAVY CHAIN
IGG1 KAPPA LIGHT
CHAIN
(Mus
musculus) 		4 / 8 LEU G  46
VAL F  90
TYR F  41
TRP G 110
 None
 1.18A 4q0bA-6cnkG:
undetectable		 4q0bA-6cnkG:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 6cnk IGG1 HEAVY CHAIN
IGG1 KAPPA LIGHT
CHAIN
(Mus
musculus) 		5 / 11 GLN F  95
TYR G 100
ALA G  98
TYR F  41
GLU G  36
 None
 1.47A 4rv6A-6cnkF:
undetectable		 4rv6A-6cnkF:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 6cnk IGG1 HEAVY CHAIN
IGG1 KAPPA LIGHT
CHAIN
(Mus
musculus) 		5 / 11 GLN F  95
TYR G 100
ALA G  98
TYR F  41
GLU G  36
 None
 1.47A 4rv6B-6cnkF:
undetectable		 4rv6B-6cnkF:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 6cnk IGG1 KAPPA LIGHT
CHAIN
(Mus
musculus) 		4 / 6 ASP F 175
THR F 177
THR F 169
SER F 179
 None
 1.47A 5b6iB-6cnkF:
undetectable		 5b6iB-6cnkF:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 6cnk IGG1 KAPPA LIGHT
CHAIN
IGG1 HEAVY CHAIN
(Mus
musculus;
Mus
musculus) 		5 / 12 GLN G 178
GLY G 151
THR F 187
TYR G 129
VAL F 138
 None
 1.11A 5d0yA-6cnkG:
undetectable		 5d0yA-6cnkG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 6cnk IGG1 KAPPA LIGHT
CHAIN
IGG1 HEAVY CHAIN
(Mus
musculus;
Mus
musculus) 		5 / 11 ASN G  60
VAL G  38
TYR G  96
PRO F  49
LEU G  46
 None
 1.34A 5jh7B-6cnkG:
undetectable		 5jh7B-6cnkG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 6cnk IGG1 KAPPA LIGHT
CHAIN
IGG1 HEAVY CHAIN
(Mus
musculus;
Mus
musculus) 		5 / 11 ASN G  60
VAL G  38
TYR G  96
PRO F  49
LEU G  46
 None
 1.31A 5jh7D-6cnkG:
undetectable		 5jh7D-6cnkG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 6cnk IGG1 KAPPA LIGHT
CHAIN
(Mus
musculus) 		3 / 3 VAL F  56
SER F  70
TRP F  40
 None
 1.07A 5jwaA-6cnkF:
undetectable		 5jwaA-6cnkF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 6cnk IGG1 HEAVY CHAIN
(Mus
musculus) 		4 / 8 TYR G  33
THR G  26
CYH G  23
LEU G   5
 None
 1.37A 5kxiA-6cnkG:
undetectable
5kxiB-6cnkG:
undetectable		 5kxiA-6cnkG:
11.58
5kxiB-6cnkG:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 6cnk IGG1 HEAVY CHAIN
(Mus
musculus) 		4 / 8 TYR G  33
THR G  26
CYH G  23
LEU G   5
 None
 1.35A 5kxiD-6cnkG:
undetectable
5kxiE-6cnkG:
undetectable		 5kxiD-6cnkG:
11.58
5kxiE-6cnkG:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 6cnk IGG1 HEAVY CHAIN
(Mus
musculus) 		4 / 4 VAL G 128
LEU G 131
ASN G 203
ASP G 214
 None
 1.35A 5vcyA-6cnkG:
undetectable		 5vcyA-6cnkG:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 6cnk IGG1 HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER G 210
ALA G 205
VAL G 204
 None
 0.55A 5xiwC-6cnkG:
undetectable		 5xiwC-6cnkG:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 6cnk IGG1 HEAVY CHAIN
IGG1 KAPPA LIGHT
CHAIN
(Mus
musculus) 		5 / 9 SER F 182
SER G 185
SER G 186
GLY G 146
THR F 119
 None
 1.17A 6awpA-6cnkF:
undetectable		 6awpA-6cnkF:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 6cnk IGG1 HEAVY CHAIN
(Mus
musculus) 		4 / 5 GLU G 155
PHE G 153
HIS G 206
THR G 117
 None
 1.13A 6b58A-6cnkG:
undetectable		 6b58A-6cnkG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 6cnk IGG1 HEAVY CHAIN
(Mus
musculus) 		5 / 12 GLY G  43
HIS G  44
VAL G 118
ARG G  41
ASP G  91
 None
 1.31A 6bxnB-6cnkG:
undetectable		 6bxnB-6cnkG:
undetectable