SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cno'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 6cno INTERMEDIATE
CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 4
(Homo
sapiens) 		5 / 10 LEU A 209
GLY A 210
LEU A 211
LEU A 213
LEU A 281
 None
 1.11A 2f8dA-6cnoA:
undetectable		 2f8dA-6cnoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 6cno INTERMEDIATE
CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 4
(Homo
sapiens) 		5 / 10 LEU A 209
GLY A 210
LEU A 211
LEU A 213
LEU A 281
 None
 1.11A 2f8dB-6cnoA:
undetectable		 2f8dB-6cnoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 6cno INTERMEDIATE
CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 4
(Homo
sapiens) 		5 / 12 LEU A 217
ILE A 244
THR A 270
LEU A 268
LEU A 223
 None
 1.04A 3hecA-6cnoA:
undetectable		 3hecA-6cnoA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 6cno INTERMEDIATE
CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 4
(Homo
sapiens) 		4 / 8 LEU A 154
PRO A 119
ARG A 159
LEU A 157
 None
 1.00A 4qknA-6cnoA:
2.3		 4qknA-6cnoA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 6cno INTERMEDIATE
CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 4
(Homo
sapiens) 		4 / 7 CYH A 267
ILE A 265
LEU A 223
ALA A 226
 None
 0.95A 5hrqE-6cnoA:
undetectable
5hrqF-6cnoA:
undetectable
5hrqJ-6cnoA:
undetectable		 5hrqE-6cnoA:
undetectable
5hrqF-6cnoA:
undetectable
5hrqJ-6cnoA:
undetectable