SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6co0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		4 / 5 HIS A 304
SER A 191
LEU A 105
GLY A 217
 None
 1.06A 1a4lB-6co0A:
undetectable		 1a4lB-6co0A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		5 / 10 GLY A 253
SER A 251
LEU A 275
THR A 379
LEU A 248
 None
 1.50A 1a8uA-6co0A:
undetectable		 1a8uA-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		4 / 5 PHE A 374
LEU A 311
VAL A 314
VAL A 370
 None
 1.15A 1t88B-6co0A:
undetectable		 1t88B-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		4 / 6 LEU A 344
GLY A 167
LEU A 371
ILE A 240
 None
 0.97A 1yajF-6co0A:
undetectable		 1yajF-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		4 / 5 PHE A 374
LEU A 311
VAL A 314
VAL A 370
 None
 1.18A 2m56A-6co0A:
undetectable		 2m56A-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		4 / 5 ALA A 115
ALA A  25
ALA A 220
VAL A 189
 None
 0.94A 2nyrB-6co0A:
undetectable		 2nyrB-6co0A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		5 / 12 ALA A  17
LEU A 171
LEU A 385
SER A 387
ILE A  22
 None
 1.13A 2oipE-6co0A:
undetectable		 2oipE-6co0A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		3 / 3 ASN A 180
ASN A 181
ARG A 155
 None
 0.95A 2rlcA-6co0A:
undetectable		 2rlcA-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		4 / 8 ILE A 224
ALA A 110
LEU A 144
ILE A 124
 None
 0.65A 2w9sE-6co0A:
undetectable		 2w9sE-6co0A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		4 / 6 THR A 169
VAL A 170
GLU A 192
CYH A 190
 None
 1.09A 3b6rB-6co0A:
undetectable		 3b6rB-6co0A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		5 / 12 VAL A 343
LEU A 171
THR A 169
VAL A 170
VAL A 223
 None
 1.21A 3czvA-6co0A:
undetectable
3czvB-6co0A:
undetectable		 3czvA-6co0A:
15.04
3czvB-6co0A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		4 / 8 VAL A 343
VAL A 370
PHE A 372
HIS A 304
 None
 1.00A 3fhxB-6co0A:
undetectable		 3fhxB-6co0A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		4 / 6 PHE A 374
LEU A 311
VAL A 314
VAL A 370
 None
 1.15A 3fwgA-6co0A:
undetectable		 3fwgA-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		5 / 12 PHE A 378
ILE A 310
ILE A 346
GLU A 192
GLY A 168
 None
WCA  A 801 ( 4.1A)
None
None
None
 1.03A 3nxuA-6co0A:
undetectable		 3nxuA-6co0A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		4 / 5 HIS A 386
SER A 387
THR A 361
ASP A 228
 None
 1.36A 3tm4A-6co0A:
undetectable		 3tm4A-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		4 / 5 HIS A 386
SER A 387
THR A 361
ASP A 228
 None
 1.38A 3tm4B-6co0A:
3.2		 3tm4B-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		4 / 8 VAL A 189
LEU A 187
ILE A 128
ASP A 141
 None
 0.70A 3wzeA-6co0A:
undetectable		 3wzeA-6co0A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		5 / 9 ILE A 255
GLY A 257
GLN A 162
GLY A 163
ARG A 172
 WCA  A 801 (-3.7A)
None
None
None
None
 1.41A 4acaB-6co0A:
undetectable
4acaC-6co0A:
undetectable		 4acaB-6co0A:
undetectable
4acaC-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		5 / 12 GLY A 375
CYH A 164
GLY A 166
GLY A 168
VAL A 276
 None
WCA  A 801 (-3.6A)
None
None
None
 1.11A 4b17A-6co0A:
undetectable		 4b17A-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		4 / 6 PHE A 374
LEU A 311
VAL A 314
VAL A 370
 None
 1.11A 4ek1A-6co0A:
undetectable		 4ek1A-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		4 / 6 PHE A 374
LEU A 311
VAL A 314
VAL A 370
 None
 1.14A 4g3rA-6co0A:
undetectable		 4g3rA-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		4 / 6 PHE A 374
LEU A 311
VAL A 314
VAL A 370
 None
 1.12A 4kkyX-6co0A:
undetectable		 4kkyX-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		4 / 5 PHE A 374
LEU A 311
VAL A 314
VAL A 370
 None
 1.18A 4l49A-6co0A:
undetectable		 4l49A-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		4 / 6 PHE A 374
LEU A 311
VAL A 314
VAL A 370
 None
 1.12A 4l4cA-6co0A:
undetectable		 4l4cA-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		5 / 11 ILE A 224
ALA A 110
ALA A 115
HIS A 126
LEU A 127
 None
 1.13A 4nqaA-6co0A:
undetectable		 4nqaA-6co0A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		4 / 6 GLU A 381
THR A 169
LEU A 173
GLN A 245
 None
 1.44A 4qztA-6co0A:
undetectable		 4qztA-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		5 / 12 ILE A 114
LEU A  20
GLY A 149
LEU A 144
THR A 145
 None
 1.16A 5byjA-6co0A:
undetectable		 5byjA-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		5 / 9 LEU A 284
ILE A 293
ILE A 302
PHE A 372
VAL A 380
 None
 1.47A 5igzA-6co0A:
undetectable		 5igzA-6co0A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		5 / 12 TRP A 301
THR A 328
LEU A 325
PHE A 374
THR A 382
 None
 1.22A 5w8aA-6co0A:
undetectable		 5w8aA-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		5 / 12 TRP A 301
THR A 328
LEU A 325
SER A 277
THR A 382
 None
 1.18A 5w8aA-6co0A:
undetectable		 5w8aA-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		4 / 7 PHE A 374
GLY A 375
GLY A 377
THR A 132
 None
 0.81A 5ybbB-6co0A:
undetectable		 5ybbB-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		5 / 12 ILE A 247
THR A 246
GLN A 245
THR A 169
VAL A 170
 None
 1.06A 6bzoC-6co0A:
undetectable		 6bzoC-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 6co0 STYRYLPYRONE
SYNTHASE 1
(Piper
methysticum) 		4 / 8 ILE A 247
THR A 246
THR A 169
ARG A 172
 None
 0.76A 6c06C-6co0A:
undetectable		 6c06C-6co0A:
undetectable