SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6con'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))
6con COA-TRANSFERASE
SUBUNIT BETA

(Mycobacterium
tuberculosis)
5 / 9 GLU B  14
ARG B  17
ARG B 224
ALA B   9
LEU B  37
None
1.39A 1mj2A-6conB:
undetectable
1mj2A-6conB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)
6con COA-TRANSFERASE
SUBUNIT BETA

(Mycobacterium
tuberculosis)
5 / 11 GLU B  14
ARG B  17
ARG B 224
ALA B   9
LEU B  37
None
1.32A 1mjlA-6conB:
undetectable
1mjlB-6conB:
undetectable
1mjlA-6conB:
undetectable
1mjlB-6conB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)
6con COA-TRANSFERASE
SUBUNIT BETA

(Mycobacterium
tuberculosis)
5 / 9 GLU B  14
ARG B  17
ARG B 224
ALA B   9
LEU B  37
None
1.38A 1mjoA-6conB:
undetectable
1mjoA-6conB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)
6con COA-TRANSFERASE
SUBUNIT BETA

(Mycobacterium
tuberculosis)
5 / 9 GLU B  14
ARG B  17
ARG B 224
ALA B   9
LEU B  37
None
1.42A 1mjoB-6conB:
undetectable
1mjoB-6conB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)
6con COA-TRANSFERASE
SUBUNIT BETA

(Mycobacterium
tuberculosis)
5 / 9 GLU B  14
ARG B  17
ARG B 224
ALA B   9
LEU B  37
None
1.41A 1mjoC-6conB:
undetectable
1mjoC-6conB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
4 / 7 VAL A  66
VAL A  36
TYR A 273
ARG A  90
None
0.99A 1t46A-6conA:
undetectable
1t46A-6conA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
4 / 6 LEU A 169
ARG A 224
THR A 208
LEU A 211
None
1.05A 1v54A-6conA:
undetectable
1v54J-6conA:
undetectable
1v54A-6conA:
undetectable
1v54J-6conA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
5 / 11 VAL A  74
GLY A  53
THR A  51
VAL A  49
VAL A  69
None
1.13A 2a1nA-6conA:
undetectable
2a1nA-6conA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
4 / 6 LEU A 169
ARG A 224
THR A 208
LEU A 211
None
1.07A 2dyrA-6conA:
undetectable
2dyrJ-6conA:
undetectable
2dyrA-6conA:
undetectable
2dyrJ-6conA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
4 / 6 LEU A 169
ARG A 224
THR A 208
LEU A 211
None
1.02A 2dysN-6conA:
undetectable
2dysW-6conA:
undetectable
2dysN-6conA:
undetectable
2dysW-6conA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
4 / 6 LEU A 169
ARG A 224
THR A 208
LEU A 211
None
1.08A 2eijA-6conA:
undetectable
2eijJ-6conA:
undetectable
2eijA-6conA:
undetectable
2eijJ-6conA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
4 / 6 LEU A 169
ARG A 224
THR A 208
LEU A 211
None
1.02A 2eilA-6conA:
undetectable
2eilJ-6conA:
undetectable
2eilA-6conA:
undetectable
2eilJ-6conA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
4 / 8 TYR A  70
ARG A  98
GLU A 136
VAL A  50
None
1.00A 2fl5E-6conA:
undetectable
2fl5F-6conA:
undetectable
2fl5E-6conA:
16.50
2fl5F-6conA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)
6con COA-TRANSFERASE
SUBUNIT BETA

(Mycobacterium
tuberculosis)
4 / 8 VAL B 237
PRO B 240
SER B 242
ARG B 244
None
0.96A 2v32C-6conB:
undetectable
2v32D-6conB:
undetectable
2v32C-6conB:
undetectable
2v32D-6conB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
5 / 12 ALA A 113
ALA A 219
ALA A 179
LEU A 200
MET A 226
None
1.22A 2x2nB-6conA:
undetectable
2x2nB-6conA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
4 / 6 LEU A 169
ARG A 224
THR A 208
LEU A 211
None
1.06A 2zxwA-6conA:
undetectable
2zxwJ-6conA:
undetectable
2zxwA-6conA:
undetectable
2zxwJ-6conA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
4 / 7 LEU A 169
ARG A 224
THR A 208
LEU A 211
None
1.07A 3ablA-6conA:
undetectable
3ablJ-6conA:
undetectable
3ablA-6conA:
undetectable
3ablJ-6conA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
4 / 6 LEU A 169
ARG A 224
THR A 208
LEU A 211
None
1.04A 3abmA-6conA:
undetectable
3abmJ-6conA:
undetectable
3abmA-6conA:
undetectable
3abmJ-6conA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
4 / 6 LEU A 169
ARG A 224
THR A 208
LEU A 211
None
1.09A 3asnA-6conA:
undetectable
3asnJ-6conA:
undetectable
3asnA-6conA:
undetectable
3asnJ-6conA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
4 / 6 LEU A 169
ARG A 224
THR A 208
LEU A 211
None
1.07A 3asoA-6conA:
undetectable
3asoJ-6conA:
undetectable
3asoA-6conA:
undetectable
3asoJ-6conA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)
6con COA-TRANSFERASE
SUBUNIT BETA

(Mycobacterium
tuberculosis)
5 / 11 ALA B  95
GLY B 157
ILE B 106
VAL B 153
SER B 154
None
1.24A 3gyqB-6conB:
undetectable
3gyqB-6conB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)
6con COA-TRANSFERASE
SUBUNIT ALPHA
COA-TRANSFERASE
SUBUNIT BETA

(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis)
5 / 12 PHE B 120
GLY A  27
SER A  75
PHE B  77
ASP A 184
None
1.30A 3iv6B-6conB:
2.3
3iv6B-6conB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
4 / 8 ALA A 219
ALA A 179
LEU A 200
MET A 226
None
1.01A 3l4dD-6conA:
undetectable
3l4dD-6conA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)
6con COA-TRANSFERASE
SUBUNIT ALPHA
COA-TRANSFERASE
SUBUNIT BETA

(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis)
4 / 5 GLY A 150
GLU A 152
GLY A 149
PRO B 166
None
1.06A 3onnA-6conA:
undetectable
3onnA-6conA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
4 / 8 TYR A 281
THR A 240
ARG A 248
LEU A  76
None
1.29A 3wipG-6conA:
undetectable
3wipH-6conA:
undetectable
3wipG-6conA:
undetectable
3wipH-6conA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
4 / 8 ASP A 184
ASP A 188
ASP A  77
ARG A 248
None
1.10A 4gkhF-6conA:
undetectable
4gkhF-6conA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
4 / 4 VAL A 206
THR A 208
GLU A 210
GLU A 209
None
1.43A 4l78A-6conA:
undetectable
4l78A-6conA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
6 / 12 ALA A  63
SER A  62
GLY A  58
GLU A 278
ALA A  34
MET A  33
None
1.20A 4r29B-6conA:
undetectable
4r29B-6conA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
5 / 12 ALA A  63
SER A  62
GLY A  58
ALA A  34
MET A  33
None
1.12A 4r29D-6conA:
undetectable
4r29D-6conA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
5 / 12 TYR A 186
THR A 240
THR A 241
ALA A 242
ALA A 243
None
1.34A 4u15A-6conA:
undetectable
4u15A-6conA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
5 / 12 TYR A 186
THR A 240
THR A 241
ALA A 242
ALA A 243
None
1.34A 4u15B-6conA:
undetectable
4u15B-6conA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
5 / 9 VAL A  74
GLY A  53
THR A  51
VAL A  49
VAL A  69
None
1.17A 5cp4A-6conA:
undetectable
5cp4A-6conA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)
6con COA-TRANSFERASE
SUBUNIT ALPHA
COA-TRANSFERASE
SUBUNIT BETA

(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis)
6 / 12 ILE A 183
TYR A 180
GLY A 182
VAL A 215
GLN A 218
ALA B  53
None
1.34A 5n0xB-6conA:
undetectable
5n0xB-6conA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)
6con COA-TRANSFERASE
SUBUNIT ALPHA
COA-TRANSFERASE
SUBUNIT BETA

(Mycobacterium
tuberculosis)
4 / 6 PRO B 126
PRO A 130
LEU A 137
PHE A 132
None
1.14A 5tl8A-6conB:
undetectable
5tl8A-6conB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
4 / 6 LEU A 169
ARG A 224
THR A 208
LEU A 211
None
1.02A 5x1fA-6conA:
undetectable
5x1fJ-6conA:
undetectable
5x1fA-6conA:
undetectable
5x1fJ-6conA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
4 / 7 PHE A  35
ALA A  11
GLN A  14
GLN A 282
None
1.27A 6b89A-6conA:
undetectable
6b89A-6conA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)
6con COA-TRANSFERASE
SUBUNIT BETA

(Mycobacterium
tuberculosis)
4 / 5 GLN B 222
THR B 223
HIS B 141
GLY B 200
None
1.19A 6gbnC-6conB:
2.8
6gbnC-6conB:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
5 / 12 GLY A  53
GLY A  54
LEU A  57
GLY A 108
PRO A  32
None
1.09A 6gngB-6conA:
2.1
6gngB-6conA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis)
4 / 7 LEU A 169
ARG A 224
THR A 208
LEU A 211
None
0.97A 6nmfA-6conA:
undetectable
6nmfJ-6conA:
undetectable
6nmfA-6conA:
undetectable
6nmfJ-6conA:
undetectable