SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cpb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QLT_A_ACTA601_0 (VANILLYL-ALCOHOL OXIDASE)	6cpb	CARBON MONOXIDE OXIDATION SYSTEM TRANSCRIPTION REGULATOR COOA-1 (Carboxydothermus hydrogenoformans)	4 / 5	TYR A 60 PHE A 86 ILE A 38 ARG A 58	None	1.39A	1qltA-6cpbA: undetectable	1qltA-6cpbA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QLT_B_ACTB601_0 (VANILLYL-ALCOHOL OXIDASE)	6cpb	CARBON MONOXIDE OXIDATION SYSTEM TRANSCRIPTION REGULATOR COOA-1 (Carboxydothermus hydrogenoformans)	4 / 5	TYR A 60 PHE A 86 ILE A 38 ARG A 58	None	1.39A	1qltB-6cpbA: undetectable	1qltB-6cpbA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LG3_F_Z80F401_1 (GAMMA-AMINOBUTYRIC-A CID RECEPTOR SUBUNIT BETA-1)	6cpb	CARBON MONOXIDE OXIDATION SYSTEM TRANSCRIPTION REGULATOR COOA-1 (Carboxydothermus hydrogenoformans)	5 / 10	ILE A 78 VAL A 49 THR A 98 GLU A 27 ILE A 106	None	1.22A	5lg3F-6cpbA: undetectable	5lg3F-6cpbA: 13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LG3_G_Z80G401_1 (GAMMA-AMINOBUTYRIC-A CID RECEPTOR SUBUNIT BETA-1)	6cpb	CARBON MONOXIDE OXIDATION SYSTEM TRANSCRIPTION REGULATOR COOA-1 (Carboxydothermus hydrogenoformans)	5 / 10	ILE A 78 VAL A 49 THR A 98 GLU A 27 ILE A 106	None	1.27A	5lg3G-6cpbA: undetectable	5lg3G-6cpbA: 13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LG3_J_Z80J401_1 (GAMMA-AMINOBUTYRIC-A CID RECEPTOR SUBUNIT BETA-1)	6cpb	CARBON MONOXIDE OXIDATION SYSTEM TRANSCRIPTION REGULATOR COOA-1 (Carboxydothermus hydrogenoformans)	5 / 12	ILE A 78 VAL A 49 THR A 98 GLU A 27 ILE A 106	None	1.19A	5lg3J-6cpbA: undetectable	5lg3J-6cpbA: 13.36

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1QLT_A_ACTA601_0","VANILLYL-ALCOHOL OXIDASE","6cpb","CARBON MONOXIDE OXIDATION SYSTEM TRANSCRIPTION REGULATOR COOA-1","Carboxydothermus hydrogenoformans",4,"TYR A  60;PHE A  86;ILE A  38;ARG A  58","None","1.39A","1qltA-6cpbA:undetectable","1qltA-6cpbA:undetectable"],["1QLT_B_ACTB601_0","VANILLYL-ALCOHOL OXIDASE","6cpb","CARBON MONOXIDE OXIDATION SYSTEM TRANSCRIPTION REGULATOR COOA-1","Carboxydothermus hydrogenoformans",4,"TYR A  60;PHE A  86;ILE A  38;ARG A  58","None","1.39A","1qltB-6cpbA:undetectable","1qltB-6cpbA:undetectable"],["5LG3_F_Z80F401_1","GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1","6cpb","CARBON MONOXIDE OXIDATION SYSTEM TRANSCRIPTION REGULATOR COOA-1","Carboxydothermus hydrogenoformans",5,"ILE A  78;VAL A  49;THR A  98;GLU A  27;ILE A 106","None","1.22A","5lg3F-6cpbA:undetectable","5lg3F-6cpbA:13.36"],["5LG3_G_Z80G401_1","GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1","6cpb","CARBON MONOXIDE OXIDATION SYSTEM TRANSCRIPTION REGULATOR COOA-1","Carboxydothermus hydrogenoformans",5,"ILE A  78;VAL A  49;THR A  98;GLU A  27;ILE A 106","None","1.27A","5lg3G-6cpbA:undetectable","5lg3G-6cpbA:13.36"],["5LG3_J_Z80J401_1","GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1","6cpb","CARBON MONOXIDE OXIDATION SYSTEM TRANSCRIPTION REGULATOR COOA-1","Carboxydothermus hydrogenoformans",5,"ILE A  78;VAL A  49;THR A  98;GLU A  27;ILE A 106","None","1.19A","5lg3J-6cpbA:undetectable","5lg3J-6cpbA:13.36"]]