SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cpl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6cpl HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		4 / 5 THR A  41
PHE A  54
GLU A  55
GLY A  58
 SO4  A 304 ( 4.1A)
NA  C 401 ( 3.4A)
None
None
 0.96A 1icrA-6cplA:
undetectable
1icrB-6cplA:
undetectable		 1icrA-6cplA:
18.48
1icrB-6cplA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6cpl HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		4 / 5 GLU A  55
GLY A  58
THR A  41
PHE A  54
 None
None
SO4  A 304 ( 4.1A)
NA  C 401 ( 3.4A)
 0.95A 1icrA-6cplA:
undetectable
1icrB-6cplA:
undetectable		 1icrA-6cplA:
18.48
1icrB-6cplA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6cpl HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		4 / 6 THR A  41
PHE A  54
GLU A  55
GLY A  58
 SO4  A 304 ( 4.1A)
NA  C 401 ( 3.4A)
None
None
 0.93A 1icuA-6cplA:
undetectable
1icuB-6cplA:
undetectable		 1icuA-6cplA:
18.48
1icuB-6cplA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6cpl HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		4 / 6 GLU A  55
GLY A  58
THR A  41
PHE A  54
 None
None
SO4  A 304 ( 4.1A)
NA  C 401 ( 3.4A)
 1.00A 1icuA-6cplA:
undetectable
1icuB-6cplA:
undetectable		 1icuA-6cplA:
18.48
1icuB-6cplA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6cpl HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		4 / 6 THR A  41
PHE A  54
GLU A  55
GLY A  58
 SO4  A 304 ( 4.1A)
NA  C 401 ( 3.4A)
None
None
 0.92A 1icuC-6cplA:
undetectable
1icuD-6cplA:
undetectable		 1icuC-6cplA:
18.48
1icuD-6cplA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6cpl HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		4 / 5 THR A  41
PHE A  54
GLU A  55
GLY A  58
 SO4  A 304 ( 4.1A)
NA  C 401 ( 3.4A)
None
None
 0.91A 1icvC-6cplA:
undetectable
1icvD-6cplA:
undetectable		 1icvC-6cplA:
18.48
1icvD-6cplA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6cpl HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		4 / 5 GLU A  55
GLY A  58
THR A  41
PHE A  54
 None
None
SO4  A 304 ( 4.1A)
NA  C 401 ( 3.4A)
 0.88A 1icvC-6cplA:
undetectable
1icvD-6cplA:
undetectable		 1icvC-6cplA:
18.48
1icvD-6cplA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6cpl HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		4 / 6 THR A  41
PHE A  54
GLU A  55
GLY A  58
 SO4  A 304 ( 4.1A)
NA  C 401 ( 3.4A)
None
None
 1.09A 1kqbA-6cplA:
undetectable
1kqbB-6cplA:
undetectable		 1kqbA-6cplA:
undetectable
1kqbB-6cplA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6cpl HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		4 / 6 THR A  41
PHE A  54
GLU A  55
GLY A  58
 SO4  A 304 ( 4.1A)
NA  C 401 ( 3.4A)
None
None
 1.06A 1kqbC-6cplA:
undetectable
1kqbD-6cplA:
undetectable		 1kqbC-6cplA:
undetectable
1kqbD-6cplA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6cpl HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		4 / 6 GLU A  55
GLY A  58
THR A  41
PHE A  54
 None
None
SO4  A 304 ( 4.1A)
NA  C 401 ( 3.4A)
 0.93A 1kqbC-6cplA:
undetectable
1kqbD-6cplA:
undetectable		 1kqbC-6cplA:
undetectable
1kqbD-6cplA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6cpl HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		4 / 6 PHE A  22
GLU A  55
GLY A  58
PHE A  54
 None
None
None
NA  C 401 ( 3.4A)
 1.15A 1kqbC-6cplA:
undetectable
1kqbD-6cplA:
undetectable		 1kqbC-6cplA:
undetectable
1kqbD-6cplA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 6cpl HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		4 / 5 GLN A   9
PHE A  24
PHE A  32
GLY A  58
 None
 1.21A 2qmzA-6cplA:
undetectable
2qmzB-6cplA:
undetectable		 2qmzA-6cplA:
15.91
2qmzB-6cplA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 6cpl HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		3 / 3 PRO A 152
SER A 133
ASN A  94
 None
 0.84A 3lslG-6cplA:
undetectable		 3lslG-6cplA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6cpl HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		4 / 5 GLU A 158
THR A 157
GLU A 179
LEU A 105
 None
 1.23A 5hm8A-6cplA:
undetectable		 5hm8A-6cplA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6cpl HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		4 / 5 GLU A 158
THR A 157
GLU A 179
LEU A 105
 None
 1.24A 5hm8B-6cplA:
undetectable		 5hm8B-6cplA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6cpl HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		4 / 5 GLU A 158
THR A 157
GLU A 179
LEU A 105
 None
 1.24A 5hm8C-6cplA:
undetectable		 5hm8C-6cplA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6cpl HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		4 / 5 GLU A 158
THR A 157
GLU A 179
LEU A 105
 None
 1.24A 5hm8D-6cplA:
undetectable		 5hm8D-6cplA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6cpl HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		4 / 5 GLU A 158
THR A 157
GLU A 179
LEU A 105
 None
 1.24A 5hm8E-6cplA:
undetectable		 5hm8E-6cplA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6cpl HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		4 / 5 GLU A 158
THR A 157
GLU A 179
LEU A 105
 None
 1.24A 5hm8F-6cplA:
undetectable		 5hm8F-6cplA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6cpl HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		4 / 5 GLU A 158
THR A 157
GLU A 179
LEU A 105
 None
 1.24A 5hm8H-6cplA:
undetectable		 5hm8H-6cplA:
11.01