SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cqb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 6cqb CHALCONE SYNTHASE
(Piper
methysticum) 		4 / 5 HIS A 304
SER A 192
LEU A 106
GLY A 217
 None
 1.06A 1a4lB-6cqbA:
undetectable		 1a4lB-6cqbA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 6cqb CHALCONE SYNTHASE
(Piper
methysticum) 		6 / 12 GLY A 373
VAL A 272
ILE A 255
GLY A 377
ILE A 247
ILE A 276
 None
 1.30A 1c6zA-6cqbA:
undetectable		 1c6zA-6cqbA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 6cqb CHALCONE SYNTHASE
(Piper
methysticum) 		6 / 11 GLY A 373
VAL A 272
ILE A 255
GLY A 377
ILE A 247
ILE A 276
 None
 1.24A 1n49B-6cqbA:
undetectable		 1n49B-6cqbA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 6cqb CHALCONE SYNTHASE
(Piper
methysticum) 		6 / 11 GLY A 373
VAL A 272
ILE A 255
GLY A 377
ILE A 247
ILE A 276
 None
 1.22A 1n49C-6cqbA:
undetectable		 1n49C-6cqbA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 6cqb CHALCONE SYNTHASE
(Piper
methysticum) 		3 / 3 ASP A  83
PHE A 199
ASN A  80
 None
 0.83A 1sg9B-6cqbA:
undetectable		 1sg9B-6cqbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 6cqb CHALCONE SYNTHASE
(Piper
methysticum) 		4 / 8 ILE A 224
ALA A 111
LEU A 145
ILE A 125
 None
 0.78A 2w9sE-6cqbA:
undetectable		 2w9sE-6cqbA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 6cqb CHALCONE SYNTHASE
(Piper
methysticum) 		5 / 10 ILE A 224
ALA A 111
LEU A 145
LEU A 151
ILE A 125
 None
 1.10A 2w9sF-6cqbA:
undetectable		 2w9sF-6cqbA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 6cqb CHALCONE SYNTHASE
(Piper
methysticum) 		4 / 6 THR A 170
VAL A 171
GLU A 193
CYH A 191
 None
 1.26A 3b6rB-6cqbA:
undetectable		 3b6rB-6cqbA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 6cqb CHALCONE SYNTHASE
(Piper
methysticum) 		5 / 11 CYH A 191
LEU A 344
ALA A 222
ALA A 175
VAL A 171
 None
 1.24A 3e22B-6cqbA:
undetectable		 3e22B-6cqbA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 6cqb CHALCONE SYNTHASE
(Piper
methysticum) 		5 / 11 CYH A 191
LEU A 344
ALA A 222
ALA A 175
VAL A 171
 None
 1.26A 3e22D-6cqbA:
undetectable		 3e22D-6cqbA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 6cqb CHALCONE SYNTHASE
(Piper
methysticum) 		4 / 8 VAL A 343
VAL A 370
PHE A 372
HIS A 304
 None
 1.01A 3fhxB-6cqbA:
undetectable		 3fhxB-6cqbA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 6cqb CHALCONE SYNTHASE
(Piper
methysticum) 		4 / 8 PHE A 374
VAL A 380
VAL A 303
ASN A 279
 None
 0.77A 3hjoB-6cqbA:
undetectable		 3hjoB-6cqbA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 6cqb CHALCONE SYNTHASE
(Piper
methysticum) 		5 / 10 ALA A 167
LEU A 344
VAL A 343
ILE A 240
LEU A 385
 None
 1.16A 3jw5B-6cqbA:
undetectable		 3jw5B-6cqbA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 6cqb CHALCONE SYNTHASE
(Piper
methysticum) 		4 / 5 PHE A 374
ILE A 276
GLY A 307
HIS A 304
 None
 1.14A 3r0lD-6cqbA:
undetectable		 3r0lD-6cqbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 6cqb CHALCONE SYNTHASE
(Piper
methysticum) 		4 / 5 ASP A 312
LEU A 311
ILE A 276
PRO A 273
 None
 1.13A 3s3vA-6cqbA:
undetectable		 3s3vA-6cqbA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 6cqb CHALCONE SYNTHASE
(Piper
methysticum) 		4 / 5 HIS A 386
SER A 387
THR A 361
ASP A 228
 None
 1.03A 3tm4A-6cqbA:
3.1		 3tm4A-6cqbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 6cqb CHALCONE SYNTHASE
(Piper
methysticum) 		4 / 5 HIS A 386
SER A 387
THR A 361
ASP A 228
 None
 1.05A 3tm4B-6cqbA:
undetectable		 3tm4B-6cqbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6cqb CHALCONE SYNTHASE
(Piper
methysticum) 		5 / 9 GLY A 307
GLY A 306
PHE A 266
ILE A 255
PHE A 216
 None
 1.22A 4fgjA-6cqbA:
undetectable
4fgjB-6cqbA:
undetectable		 4fgjA-6cqbA:
undetectable
4fgjB-6cqbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6cqb CHALCONE SYNTHASE
(Piper
methysticum) 		4 / 6 PHE A 266
ILE A 255
PRO A 376
PHE A 216
 None
 1.21A 4fgkA-6cqbA:
undetectable		 4fgkA-6cqbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 6cqb CHALCONE SYNTHASE
(Piper
methysticum) 		6 / 11 GLY A 373
VAL A 272
ILE A 255
GLY A 377
ILE A 247
ILE A 276
 None
 1.33A 4njvC-6cqbA:
undetectable		 4njvC-6cqbA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 6cqb CHALCONE SYNTHASE
(Piper
methysticum) 		4 / 8 TYR A  37
THR A 195
CYH A  85
LEU A  73
 None
 1.48A 5kxiA-6cqbA:
undetectable
5kxiB-6cqbA:
undetectable		 5kxiA-6cqbA:
11.66
5kxiB-6cqbA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6cqb CHALCONE SYNTHASE
(Piper
methysticum) 		5 / 10 PHE A 266
ILE A 255
PHE A 216
GLY A 307
GLY A 306
 None
 1.16A 5lbtA-6cqbA:
undetectable
5lbtB-6cqbA:
undetectable		 5lbtA-6cqbA:
18.72
5lbtB-6cqbA:
18.72