SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cri'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)
6cri -
(-)
3 / 3 THR M 152
THR M 154
PRO M 150
None
0.86A 1a7yB-6criM:
undetectable
1a7yB-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)
6cri -
(-)
4 / 8 VAL M 378
LEU M 420
SER M 281
VAL M 295
None
1.18A 1jtvA-6criM:
undetectable
1jtvA-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
6cri -
(-)
4 / 8 ALA S 131
GLU S 125
ILE S 123
ILE S  83
None
0.89A 1p7lD-6criS:
undetectable
1p7lD-6criS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
6cri -
(-)
4 / 8 ALA S 131
GLU S 125
ILE S 123
ILE S  83
None
0.88A 1p7lC-6criS:
undetectable
1p7lC-6criS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
6cri -
(-)
4 / 8 ALA S 131
GLU S 125
ILE S 123
ILE S  83
None
0.88A 1rg9B-6criS:
undetectable
1rg9B-6criS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
6cri -
(-)
4 / 8 ALA S 131
GLU S 125
ILE S 123
ILE S  83
None
0.90A 1rg9A-6criS:
undetectable
1rg9A-6criS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
6cri -
(-)
4 / 8 ALA S 131
GLU S 125
ILE S 123
ILE S  83
None
0.89A 1rg9D-6criS:
undetectable
1rg9D-6criS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
6cri -
(-)
4 / 8 ALA S 131
GLU S 125
ILE S 123
ILE S  83
None
0.88A 1rg9C-6criS:
undetectable
1rg9C-6criS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)
6cri -
(-)
3 / 3 TYR G  55
ARG G  24
GLN G  20
None
0.76A 1tw4A-6criG:
undetectable
1tw4A-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)
6cri -
(-)
3 / 3 THR M 154
PRO M 150
THR M 152
None
0.85A 1unjF-6criM:
undetectable
1unjF-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)
6cri -
(-)
3 / 3 THR M 152
THR M 154
PRO M 150
None
0.85A 1unjF-6criM:
undetectable
1unjF-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)
6cri -
(-)
4 / 5 LEU G 197
LEU G 198
LEU G 191
LEU G 182
None
1.05A 2ab2B-6criG:
undetectable
2ab2B-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)
6cri -
(-)
4 / 6 ALA G 139
PHE G 175
ILE G 165
VAL G 168
None
0.89A 2cizA-6criG:
undetectable
2cizA-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)
6cri -
(-)
5 / 9 GLY M 330
ILE M 341
THR M 422
VAL M 295
ILE M 279
None
1.20A 2nnhB-6criM:
undetectable
2nnhB-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)
6cri

(;
)
3 / 3 ARG S  42
SER G 360
TYR S  59
None
1.01A 2q2hA-6criS:
undetectable
2q2hB-6criS:
undetectable
2q2hA-6criS:
undetectable
2q2hB-6criS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)
6cri

(;
)
3 / 3 PRO G  62
ASN M 318
ARG G  35
None
1.06A 2qeuB-6criG:
2.1
2qeuB-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VTB_B_ACTB1500_0
(CRYPTOCHROME DASH)
6cri -
(-)
4 / 4 ARG M 251
PHE M 238
VAL M 236
ASP M 235
None
1.15A 2vtbB-6criM:
0.0
2vtbB-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)
6cri -
(-)
5 / 12 VAL M 392
THR M 413
VAL M 179
SER M 192
TYR M 267
None
1.29A 2y00B-6criM:
undetectable
2y00B-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)
6cri -
(-)
5 / 12 VAL M 392
THR M 413
VAL M 179
SER M 192
TYR M 267
None
1.25A 2y01B-6criM:
undetectable
2y01B-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
6cri -
(-)
5 / 12 ALA G 408
ALA G 401
VAL G 433
CYH G 479
LEU G 459
None
1.24A 3b0wA-6criG:
undetectable
3b0wA-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)
6cri -
(-)
3 / 3 CYH G 400
PRO G 394
ASP G 390
None
0.89A 3hlwB-6criG:
undetectable
3hlwB-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
6cri -
(-)
4 / 8 GLU M 193
SER M 192
ARG M 421
VAL M 189
None
1.21A 3jx1A-6criM:
undetectable
3jx1B-6criM:
undetectable
3jx1A-6criM:
undetectable
3jx1B-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
6cri -
(-)
3 / 3 ALA G 412
ARG G 379
LYS G 383
None
1.00A 3kp5B-6criG:
undetectable
3kp5B-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)
6cri

(;
)
3 / 3 ASP G 358
SER G 360
ARG S  42
None
0.97A 3loqA-6criG:
undetectable
3loqA-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)
6cri -
(-)
4 / 7 ILE G 508
LEU G 472
THR G 455
THR G 519
None
1.24A 3nxuA-6criG:
undetectable
3nxuA-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
6cri -
(-)
4 / 8 GLU M 193
SER M 192
ARG M 421
VAL M 189
None
1.19A 3rqlA-6criM:
undetectable
3rqlB-6criM:
undetectable
3rqlA-6criM:
undetectable
3rqlB-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ACTA908_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)
6cri -
(-)
4 / 4 MET G 267
SER G 263
LEU G 253
VAL G 216
None
1.50A 3vlnA-6criG:
1.4
3vlnA-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)
6cri -
(-)
5 / 12 TYR G  55
LEU G  59
GLY G  60
TYR G  61
LEU G  87
None
1.00A 3vywC-6criG:
undetectable
3vywC-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)
6cri -
(-)
4 / 5 ASP G 298
THR G 295
LEU G 294
LYS G 334
None
1.36A 4a3pA-6criG:
undetectable
4a3pA-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)
6cri -
(-)
4 / 5 ILE G  14
ALA G  17
MET G  26
ARG G  24
None
0.91A 4ac9B-6criG:
undetectable
4ac9C-6criG:
undetectable
4ac9B-6criG:
undetectable
4ac9C-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)
6cri -
(-)
4 / 5 ILE G  14
ALA G  17
MET G  26
ARG G  24
None
0.88A 4acaB-6criG:
undetectable
4acaC-6criG:
undetectable
4acaB-6criG:
undetectable
4acaC-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)
6cri
()
3 / 3 ARG G  15
ARG G  12
ILE S 104
None
0.81A 4b7qA-6criG:
undetectable
4b7qA-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)
6cri
()
3 / 3 ARG G  15
ARG G  12
ILE S 104
None
0.89A 4b7qC-6criG:
undetectable
4b7qC-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)
6cri -
(-)
4 / 7 VAL G 473
SER G 515
GLN G 470
ASP G 466
None
1.09A 4hxyB-6criG:
undetectable
4hxyB-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)
6cri -
(-)
4 / 4 LYS G 144
LEU G 145
GLU G 141
LEU G 111
None
1.39A 4k4yE-6criG:
3.1
4k4yE-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)
6cri -
(-)
3 / 3 ARG M 290
HIS M 359
SER M 289
None
0.95A 4mjwA-6criM:
undetectable
4mjwB-6criM:
undetectable
4mjwA-6criM:
undetectable
4mjwB-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)
6cri -
(-)
3 / 3 SER M 289
ARG M 290
HIS M 359
None
0.96A 4mjwA-6criM:
undetectable
4mjwB-6criM:
undetectable
4mjwA-6criM:
undetectable
4mjwB-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)
6cri -
(-)
4 / 5 HIS M 313
VAL M 378
GLU M 311
LYS M 333
None
1.34A 4p6vB-6criM:
undetectable
4p6vE-6criM:
undetectable
4p6vB-6criM:
undetectable
4p6vE-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)
6cri
()
5 / 12 LEU G   7
GLU S 108
LEU G  73
GLY G  88
PHE S 107
None
1.29A 4pgfA-6criG:
undetectable
4pgfA-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)
6cri -
(-)
3 / 3 CYH G 400
PRO G 394
ASP G 390
None
0.89A 4pm5A-6criG:
undetectable
4pm5A-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_A_PARA500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)
6cri
()
5 / 10 PHE S 107
GLU M 368
ASP S  25
TYR G  61
GLY G  60
None
1.46A 4qb9A-6criS:
undetectable
4qb9A-6criS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
6cri -
(-)
4 / 8 GLU M 193
SER M 192
ARG M 421
VAL M 189
None
1.18A 4v3yA-6criM:
undetectable
4v3yB-6criM:
undetectable
4v3yA-6criM:
undetectable
4v3yB-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)
6cri -
(-)
5 / 12 PHE M 255
LEU M 210
LEU M 204
VAL M 171
PHE M 262
None
1.25A 5im2A-6criM:
undetectable
5im2A-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)
6cri
()
5 / 12 ILE S  83
ILE S  71
ASP S  75
VAL G 247
LEU G 245
None
1.20A 5jkvA-6criS:
undetectable
5jkvA-6criS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)
6cri -
(-)
5 / 10 ILE M  60
LEU M  98
VAL M   8
LEU M  16
GLU M 100
None
1.32A 5tixB-6criM:
undetectable
5tixB-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)
6cri -
(-)
5 / 10 ILE M 109
LEU M  65
PHE M  95
SER M 102
GLU M  99
None
1.35A 5tixB-6criM:
undetectable
5tixB-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)
6cri -
(-)
4 / 5 PRO M 150
GLU M 162
ARG M 160
THR M 152
None
1.49A 5uxcA-6criM:
undetectable
5uxcA-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)
6cri -
(-)
4 / 6 GLU M 100
LEU M  16
LYS M  12
LEU M  11
None
1.04A 5yvnA-6criM:
undetectable
5yvnA-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)
6cri

(;
)
4 / 6 GLU S  89
ARG S  86
VAL G 284
PRO G 243
None
1.42A 6fgdA-6criS:
undetectable
6fgdA-6criS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_0
(BETA-1 ADRENERGIC
RECEPTOR)
6cri -
(-)
5 / 12 VAL M 392
THR M 413
VAL M 179
SER M 192
TYR M 267
None
1.20A 6h7lA-6criM:
undetectable
6h7lA-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_0
(BETA-1 ADRENERGIC
RECEPTOR)
6cri -
(-)
5 / 12 VAL M 392
THR M 413
VAL M 179
SER M 192
TYR M 267
None
1.18A 6h7lB-6criM:
undetectable
6h7lB-6criM:
undetectable