SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6crj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_2
(DIHYDROFOLATE
REDUCTASE)		 6crj NORWALK VIRUS, MNV-1
CAPSID PROTEIN
CHIMERA
(Norwalk
virus) 		4 / 4 TRP B 460
LEU B 491
ARG B 244
THR B 279
 None
 1.50A 1ao8A-6crjB:
0.0		 1ao8A-6crjB:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 6crj NORWALK VIRUS, MNV-1
CAPSID PROTEIN
CHIMERA
(Norwalk
virus) 		4 / 6 THR B 196
THR B 119
ASN B  74
ASP B  78
 None
 1.27A 2okcA-6crjB:
undetectable		 2okcA-6crjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 6crj NORWALK VIRUS, MNV-1
CAPSID PROTEIN
CHIMERA
(Norwalk
virus) 		5 / 12 PRO B 325
LEU B 309
ILE B 337
THR B 353
VAL B 387
 None
 1.40A 3a51B-6crjB:
undetectable		 3a51B-6crjB:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 6crj NORWALK VIRUS, MNV-1
CAPSID PROTEIN
CHIMERA
(Norwalk
virus) 		5 / 12 GLY B 115
ALA B 117
PHE B 118
THR B 119
LEU B 190
 None
 1.12A 3dh0A-6crjB:
undetectable		 3dh0A-6crjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 6crj NORWALK VIRUS, MNV-1
CAPSID PROTEIN
CHIMERA
(Norwalk
virus) 		5 / 12 LEU B 491
TYR B 492
GLY B 421
GLY B 495
LEU B 453
 None
 1.19A 3e23A-6crjB:
undetectable		 3e23A-6crjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 6crj NORWALK VIRUS, MNV-1
CAPSID PROTEIN
CHIMERA
(Norwalk
virus) 		4 / 8 THR B 119
GLY B 121
LEU B 190
ILE B  70
 None
 0.89A 3nbqB-6crjB:
undetectable		 3nbqB-6crjB:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 6crj NORWALK VIRUS, MNV-1
CAPSID PROTEIN
CHIMERA
(Norwalk
virus) 		4 / 8 THR B 119
GLY B 121
LEU B 190
ILE B  70
 None
 0.82A 3nbqC-6crjB:
undetectable		 3nbqC-6crjB:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 6crj NORWALK VIRUS, MNV-1
CAPSID PROTEIN
CHIMERA
(Norwalk
virus) 		5 / 9 ASP B 198
PHE B 200
VAL B 152
THR B 119
GLY B 115
 None
 1.34A 4acaB-6crjB:
undetectable
4acaC-6crjB:
3.3		 4acaB-6crjB:
undetectable
4acaC-6crjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 6crj NORWALK VIRUS, MNV-1
CAPSID PROTEIN
CHIMERA
(Norwalk
virus) 		5 / 11 VAL B 391
PHE B 289
TYR B 295
ALA B 305
PHE B 355
 None
 1.40A 4evrA-6crjB:
undetectable		 4evrA-6crjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 6crj NORWALK VIRUS, MNV-1
CAPSID PROTEIN
CHIMERA
(Norwalk
virus) 		4 / 8 THR B 279
PRO B 280
VAL B 286
SER B 287
 None
 1.19A 4qknA-6crjB:
3.1		 4qknA-6crjB:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 6crj NORWALK VIRUS, MNV-1
CAPSID PROTEIN
CHIMERA
(Norwalk
virus) 		5 / 12 VAL B 230
ASP B 231
THR B 279
GLN B 455
LEU B 453
 None
 1.49A 5m54B-6crjB:
undetectable		 5m54B-6crjB:
11.97