SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cty'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		4 / 5 HIS A  17
HIS A 140
HIS A 178
ASP A 251
 ZN  A 402 (-3.4A)
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.4A)
ZN  A 402 ( 2.8A)
 0.63A 1e9yB-6ctyA:
18.2		 1e9yB-6ctyA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		5 / 6 HIS A  17
HIS A  19
HIS A 140
HIS A 178
ASP A 251
 ZN  A 402 (-3.4A)
ZN  A 402 ( 3.3A)
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.4A)
ZN  A 402 ( 2.8A)
 0.62A 1fweC-6ctyA:
6.2		 1fweC-6ctyA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		4 / 7 LEU A 162
LEU A 104
TYR A 124
LEU A 172
 None
KCX  A 103 ( 4.5A)
None
None
 1.10A 1kt3A-6ctyA:
undetectable		 1kt3A-6ctyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		5 / 12 ALA A 184
PHE A 157
ILE A 165
ILE A 139
THR A 181
 None
 1.00A 1ra2A-6ctyA:
undetectable		 1ra2A-6ctyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		5 / 12 ALA A 184
PHE A 157
ILE A 165
ILE A 139
THR A 181
 None
 1.00A 1rb2A-6ctyA:
undetectable		 1rb2A-6ctyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		5 / 12 ALA A 184
PHE A 157
ILE A 165
ILE A 139
THR A 181
 None
 1.04A 1re7A-6ctyA:
undetectable		 1re7A-6ctyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		5 / 12 ALA A 184
PHE A 157
ILE A 165
ILE A 139
THR A 181
 None
 1.02A 1rx2A-6ctyA:
undetectable		 1rx2A-6ctyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		3 / 3 GLU A 177
HIS A  17
THR A 198
 None
ZN  A 402 (-3.4A)
None
 0.89A 3hkuA-6ctyA:
undetectable		 3hkuA-6ctyA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		5 / 10 ALA A 184
PHE A 157
ILE A 165
ILE A 139
THR A 181
 None
 1.06A 3qgtB-6ctyA:
undetectable		 3qgtB-6ctyA:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		5 / 12 ASP A 251
HIS A  17
HIS A  19
ALA A 267
CYH A 222
 ZN  A 402 ( 2.8A)
ZN  A 402 (-3.4A)
ZN  A 402 ( 3.3A)
CSX  A 266 (-3.6A)
None
 1.10A 3r2jC-6ctyA:
undetectable		 3r2jC-6ctyA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		5 / 9 ALA A 184
PHE A 157
ILE A 165
ILE A 139
THR A 181
 None
 1.11A 3tq8A-6ctyA:
undetectable		 3tq8A-6ctyA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		4 / 4 ASN A  45
SER A  27
LEU A  26
THR A 111
 MLT  A 403 (-3.6A)
None
None
MLT  A 403 (-3.2A)
 1.40A 4an2A-6ctyA:
undetectable		 4an2A-6ctyA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		4 / 7 ILE A  18
LEU A  20
ALA A  40
ALA A 272
 None
 0.78A 4g77A-6ctyA:
undetectable		 4g77A-6ctyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		4 / 5 HIS A  17
HIS A 140
HIS A 178
ASP A 251
 ZN  A 402 (-3.4A)
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.4A)
ZN  A 402 ( 2.8A)
 0.61A 4h9mA-6ctyA:
3.7		 4h9mA-6ctyA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		5 / 12 ALA A 184
PHE A 157
ILE A 165
ILE A 139
THR A 181
 None
 1.03A 4kjlA-6ctyA:
undetectable		 4kjlA-6ctyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		4 / 5 ILE A 150
ARG A 156
ASP A 183
GLU A 142
 None
 1.23A 4nkxD-6ctyA:
undetectable		 4nkxD-6ctyA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		5 / 12 ALA A 184
PHE A 157
ILE A 165
ILE A 139
THR A 181
 None
 1.04A 4pstA-6ctyA:
undetectable		 4pstA-6ctyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		5 / 12 ALA A 184
PHE A 157
ILE A 165
ILE A 139
THR A 181
 None
 0.98A 4ptjA-6ctyA:
undetectable		 4ptjA-6ctyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		5 / 6 HIS A  17
HIS A  19
HIS A 140
HIS A 178
ASP A 251
 ZN  A 402 (-3.4A)
ZN  A 402 ( 3.3A)
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.4A)
ZN  A 402 ( 2.8A)
 0.49A 4ubpC-6ctyA:
19.4		 4ubpC-6ctyA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		5 / 12 ALA A 184
PHE A 157
ILE A 165
ILE A 139
THR A 181
 None
 1.06A 5e8qA-6ctyA:
undetectable		 5e8qA-6ctyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		4 / 7 ALA A 256
LYS A 260
GLU A 261
HIS A 258
 None
CSX  A 266 ( 2.7A)
None
None
 1.21A 5ecnA-6ctyA:
0.0		 5ecnA-6ctyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		4 / 4 ASP A 251
HIS A 178
HIS A 140
HIS A  19
 ZN  A 402 ( 2.8A)
ZN  A 401 ( 3.4A)
ZN  A 401 ( 3.2A)
ZN  A 402 ( 3.3A)
 1.46A 5ncdD-6ctyA:
3.7		 5ncdD-6ctyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		5 / 8 ASP A 251
HIS A 178
HIS A 140
PRO A 224
HIS A  19
 ZN  A 402 ( 2.8A)
ZN  A 401 ( 3.4A)
ZN  A 401 ( 3.2A)
None
ZN  A 402 ( 3.3A)
 1.37A 5nekB-6ctyA:
3.8		 5nekB-6ctyA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		3 / 3 MET A  77
GLU A  61
ARG A  60
 None
 0.76A 5tjzA-6ctyA:
undetectable		 5tjzA-6ctyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		4 / 5 ASN A 299
ASP A 244
SER A 243
ARG A 245
 None
 1.40A 5w4zA-6ctyA:
5.5		 5w4zA-6ctyA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 6cty DIHYDROOROTASE
(Yersinia
pestis) 		5 / 12 ALA A 184
PHE A 157
ILE A 165
ILE A 139
THR A 181
 None
 0.94A 7dfrA-6ctyA:
undetectable		 7dfrA-6ctyA:
undetectable