SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cu5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JTX_A_CVIA200_0 (HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION)	6cu5	PROTEIN ARGININE N-METHYLTRANSFERASE (Naegleria fowleri)	5 / 12	THR A 28 TYR A 31 ILE A 118 ILE A 78 ALA A 81	None	1.18A	1jtxA-6cu5A: undetectable	1jtxA-6cu5A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UDT_A_VIAA1000_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	6cu5	PROTEIN ARGININE N-METHYLTRANSFERASE (Naegleria fowleri)	5 / 12	ALA A 64 ILE A 35 VAL A 47 LEU A 143 PHE A 150	None	1.30A	1udtA-6cu5A: undetectable	1udtA-6cu5A: 12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WOP_A_FFOA2888_0 (AMINOMETHYLTRANSFERA SE)	6cu5	PROTEIN ARGININE N-METHYLTRANSFERASE (Naegleria fowleri)	5 / 10	LEU A 223 LEU A 127 ILE A 226 GLU A 260 MET A 156	None	1.24A	1wopA-6cu5A: undetectable	1wopA-6cu5A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2H42_A_VIAA901_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	6cu5	PROTEIN ARGININE N-METHYLTRANSFERASE (Naegleria fowleri)	5 / 11	ALA A 64 ILE A 35 VAL A 47 LEU A 143 PHE A 150	None	1.26A	2h42A-6cu5A: undetectable	2h42A-6cu5A: 12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BUF_A_AEGA394_0 (BETA-SECRETASE 1)	6cu5	PROTEIN ARGININE N-METHYLTRANSFERASE (Naegleria fowleri)	4 / 5	ASP A 73 ILE A 94 ILE A 78 GLY A 51	SAH A 401 (-2.9A) None None SAH A 401 (-3.1A)	0.88A	3bufA-6cu5A: undetectable	3bufA-6cu5A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ETE_A_H3PA552_1 (GLUTAMATE DEHYDROGENASE)	6cu5	PROTEIN ARGININE N-METHYLTRANSFERASE (Naegleria fowleri)	4 / 6	ILE A 56 TYR A 90 LYS A 63 ILE A 35	None	1.14A	3eteA-6cu5A: 3.6 3eteE-6cu5A: undetectable	3eteA-6cu5A: 8.84 3eteE-6cu5A: 8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ETE_C_H3PC554_1 (GLUTAMATE DEHYDROGENASE)	6cu5	PROTEIN ARGININE N-METHYLTRANSFERASE (Naegleria fowleri)	4 / 5	ILE A 84 TYR A 90 ILE A 56 HIS A 18	None None None SAH A 401 (-4.1A)	0.95A	3eteB-6cu5A: undetectable 3eteC-6cu5A: 3.6	3eteB-6cu5A: 8.84 3eteC-6cu5A: 8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ETE_F_H3PF552_1 (GLUTAMATE DEHYDROGENASE)	6cu5	PROTEIN ARGININE N-METHYLTRANSFERASE (Naegleria fowleri)	4 / 7	ILE A 56 HIS A 18 ILE A 84 TYR A 90	None SAH A 401 (-4.1A) None None	0.95A	3eteD-6cu5A: 3.8 3eteF-6cu5A: undetectable	3eteD-6cu5A: 8.84 3eteF-6cu5A: 8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ETE_F_H3PF552_1 (GLUTAMATE DEHYDROGENASE)	6cu5	PROTEIN ARGININE N-METHYLTRANSFERASE (Naegleria fowleri)	4 / 7	LYS A 63 ILE A 35 ILE A 56 TYR A 90	None	1.14A	3eteD-6cu5A: 3.8 3eteF-6cu5A: undetectable	3eteD-6cu5A: 8.84 3eteF-6cu5A: 8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G88_A_SAMA303_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE G)	6cu5	PROTEIN ARGININE N-METHYLTRANSFERASE (Naegleria fowleri)	5 / 11	GLY A 51 GLY A 53 ASP A 73 GLU A 102 ARG A 27	SAH A 401 (-3.1A) SAH A 401 ( 4.0A) SAH A 401 (-2.9A) SAH A 401 (-3.6A) SAH A 401 (-2.4A)	0.98A	3g88A-6cu5A: 9.7	3g88A-6cu5A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G88_B_SAMB303_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE G)	6cu5	PROTEIN ARGININE N-METHYLTRANSFERASE (Naegleria fowleri)	5 / 11	GLY A 51 GLY A 53 ASP A 73 GLU A 102 ARG A 27	SAH A 401 (-3.1A) SAH A 401 ( 4.0A) SAH A 401 (-2.9A) SAH A 401 (-3.6A) SAH A 401 (-2.4A)	1.00A	3g88B-6cu5A: 8.7	3g88B-6cu5A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G89_A_SAMA303_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE G)	6cu5	PROTEIN ARGININE N-METHYLTRANSFERASE (Naegleria fowleri)	5 / 12	GLY A 51 GLY A 53 ASP A 73 GLU A 102 ARG A 27	SAH A 401 (-3.1A) SAH A 401 ( 4.0A) SAH A 401 (-2.9A) SAH A 401 (-3.6A) SAH A 401 (-2.4A)	0.95A	3g89A-6cu5A: 9.9	3g89A-6cu5A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G89_B_SAMB303_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE G)	6cu5	PROTEIN ARGININE N-METHYLTRANSFERASE (Naegleria fowleri)	5 / 11	GLY A 51 GLY A 53 ASP A 73 GLU A 102 ARG A 27	SAH A 401 (-3.1A) SAH A 401 ( 4.0A) SAH A 401 (-2.9A) SAH A 401 (-3.6A) SAH A 401 (-2.4A)	0.95A	3g89B-6cu5A: 9.0	3g89B-6cu5A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G8B_A_SAMA303_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE G)	6cu5	PROTEIN ARGININE N-METHYLTRANSFERASE (Naegleria fowleri)	5 / 12	GLY A 51 GLY A 53 ASP A 73 GLU A 102 ARG A 27	SAH A 401 (-3.1A) SAH A 401 ( 4.0A) SAH A 401 (-2.9A) SAH A 401 (-3.6A) SAH A 401 (-2.4A)	0.95A	3g8bA-6cu5A: 9.2	3g8bA-6cu5A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G8B_B_SAMB303_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE G)	6cu5	PROTEIN ARGININE N-METHYLTRANSFERASE (Naegleria fowleri)	5 / 12	GLY A 51 GLY A 53 ASP A 73 GLU A 102 ARG A 27	SAH A 401 (-3.1A) SAH A 401 ( 4.0A) SAH A 401 (-2.9A) SAH A 401 (-3.6A) SAH A 401 (-2.4A)	0.93A	3g8bB-6cu5A: 8.0	3g8bB-6cu5A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QZT_C_RTLC201_0 (RETINOL-BINDING PROTEIN 2)	6cu5	PROTEIN ARGININE N-METHYLTRANSFERASE (Naegleria fowleri)	5 / 12	PHE A 125 ILE A 295 ALA A 245 LEU A 211 LEU A 127	None	1.49A	4qztC-6cu5A: undetectable	4qztC-6cu5A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KMF_A_6U9A1301_1 (ION TRANSPORT PROTEIN)	6cu5	PROTEIN ARGININE N-METHYLTRANSFERASE (Naegleria fowleri)	4 / 6	THR A 267 GLY A 264 TYR A 157 ILE A 158	None	0.93A	5kmfA-6cu5A: undetectable 5kmfC-6cu5A: undetectable	5kmfA-6cu5A: 16.92 5kmfC-6cu5A: 16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KXI_A_NCTA402_1 (NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4 NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2)	6cu5	PROTEIN ARGININE N-METHYLTRANSFERASE (Naegleria fowleri)	4 / 8	CYH A 249 CYH A 154 TRP A 272 LEU A 126	None	1.22A	5kxiA-6cu5A: undetectable 5kxiB-6cu5A: undetectable	5kxiA-6cu5A: 10.36 5kxiB-6cu5A: 10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KXI_D_NCTD402_1 (NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4 NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2)	6cu5	PROTEIN ARGININE N-METHYLTRANSFERASE (Naegleria fowleri)	4 / 8	CYH A 249 CYH A 154 TRP A 272 LEU A 126	None	1.23A	5kxiD-6cu5A: undetectable 5kxiE-6cu5A: undetectable	5kxiD-6cu5A: 10.36 5kxiE-6cu5A: 10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CDU_B_EY4B500_0 (CHIMERIC ALPHA1GABAA RECEPTOR)	6cu5	PROTEIN ARGININE N-METHYLTRANSFERASE (Naegleria fowleri)	4 / 6	GLN A 274 VAL A 276 PRO A 265 ALA A 242	None	1.02A	6cduB-6cu5A: undetectable 6cduC-6cu5A: undetectable	6cduB-6cu5A: undetectable 6cduC-6cu5A: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1JTX_A_CVIA200_0","HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION","6cu5","PROTEIN ARGININE N-METHYLTRANSFERASE","Naegleria fowleri",5,"THR A  28;TYR A  31;ILE A 118;ILE A  78;ALA A  81","None","1.18A","1jtxA-6cu5A:undetectable","1jtxA-6cu5A:undetectable"],["1UDT_A_VIAA1000_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","6cu5","PROTEIN ARGININE N-METHYLTRANSFERASE","Naegleria fowleri",5,"ALA A  64;ILE A  35;VAL A  47;LEU A 143;PHE A 150","None","1.30A","1udtA-6cu5A:undetectable","1udtA-6cu5A:12.98"],["1WOP_A_FFOA2888_0","AMINOMETHYLTRANSFERASE","6cu5","PROTEIN ARGININE N-METHYLTRANSFERASE","Naegleria fowleri",5,"LEU A 223;LEU A 127;ILE A 226;GLU A 260;MET A 156","None","1.24A","1wopA-6cu5A:undetectable","1wopA-6cu5A:undetectable"],["2H42_A_VIAA901_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","6cu5","PROTEIN ARGININE N-METHYLTRANSFERASE","Naegleria fowleri",5,"ALA A  64;ILE A  35;VAL A  47;LEU A 143;PHE A 150","None","1.26A","2h42A-6cu5A:undetectable","2h42A-6cu5A:12.89"],["3BUF_A_AEGA394_0","BETA-SECRETASE 1","6cu5","PROTEIN ARGININE N-METHYLTRANSFERASE","Naegleria fowleri",4,"ASP A  73;ILE A  94;ILE A  78;GLY A  51","SAH A 401 (-2.9A);None;None;SAH A 401 (-3.1A)","0.88A","3bufA-6cu5A:undetectable","3bufA-6cu5A:undetectable"],["3ETE_A_H3PA552_1","GLUTAMATE DEHYDROGENASE;GLUTAMATE DEHYDROGENASE","6cu5","PROTEIN ARGININE N-METHYLTRANSFERASE","Naegleria fowleri",4,"ILE A  56;TYR A  90;LYS A  63;ILE A  35","None","1.14A","3eteA-6cu5A:3.6;3eteE-6cu5A:undetectable","3eteA-6cu5A:8.84;3eteE-6cu5A:8.84"],["3ETE_C_H3PC554_1","GLUTAMATE DEHYDROGENASE;GLUTAMATE DEHYDROGENASE","6cu5","PROTEIN ARGININE N-METHYLTRANSFERASE","Naegleria fowleri",4,"ILE A  84;TYR A  90;ILE A  56;HIS A  18","None;None;None;SAH A 401 (-4.1A)","0.95A","3eteB-6cu5A:undetectable;3eteC-6cu5A:3.6","3eteB-6cu5A:8.84;3eteC-6cu5A:8.84"],["3ETE_F_H3PF552_1","GLUTAMATE DEHYDROGENASE;GLUTAMATE DEHYDROGENASE","6cu5","PROTEIN ARGININE N-METHYLTRANSFERASE","Naegleria fowleri",4,"ILE A  56;HIS A  18;ILE A  84;TYR A  90","None;SAH A 401 (-4.1A);None;None","0.95A","3eteD-6cu5A:3.8;3eteF-6cu5A:undetectable","3eteD-6cu5A:8.84;3eteF-6cu5A:8.84"],["3ETE_F_H3PF552_1","GLUTAMATE DEHYDROGENASE;GLUTAMATE DEHYDROGENASE","6cu5","PROTEIN ARGININE N-METHYLTRANSFERASE","Naegleria fowleri",4,"LYS A  63;ILE A  35;ILE A  56;TYR A  90","None","1.14A","3eteD-6cu5A:3.8;3eteF-6cu5A:undetectable","3eteD-6cu5A:8.84;3eteF-6cu5A:8.84"],["3G88_A_SAMA303_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE G","6cu5","PROTEIN ARGININE N-METHYLTRANSFERASE","Naegleria fowleri",5,"GLY A  51;GLY A  53;ASP A  73;GLU A 102;ARG A  27","SAH A 401 (-3.1A);SAH A 401 ( 4.0A);SAH A 401 (-2.9A);SAH A 401 (-3.6A);SAH A 401 (-2.4A)","0.98A","3g88A-6cu5A:9.7","3g88A-6cu5A:undetectable"],["3G88_B_SAMB303_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE G","6cu5","PROTEIN ARGININE N-METHYLTRANSFERASE","Naegleria fowleri",5,"GLY A  51;GLY A  53;ASP A  73;GLU A 102;ARG A  27","SAH A 401 (-3.1A);SAH A 401 ( 4.0A);SAH A 401 (-2.9A);SAH A 401 (-3.6A);SAH A 401 (-2.4A)","1.00A","3g88B-6cu5A:8.7","3g88B-6cu5A:undetectable"],["3G89_A_SAMA303_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE G","6cu5","PROTEIN ARGININE N-METHYLTRANSFERASE","Naegleria fowleri",5,"GLY A  51;GLY A  53;ASP A  73;GLU A 102;ARG A  27","SAH A 401 (-3.1A);SAH A 401 ( 4.0A);SAH A 401 (-2.9A);SAH A 401 (-3.6A);SAH A 401 (-2.4A)","0.95A","3g89A-6cu5A:9.9","3g89A-6cu5A:undetectable"],["3G89_B_SAMB303_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE G","6cu5","PROTEIN ARGININE N-METHYLTRANSFERASE","Naegleria fowleri",5,"GLY A  51;GLY A  53;ASP A  73;GLU A 102;ARG A  27","SAH A 401 (-3.1A);SAH A 401 ( 4.0A);SAH A 401 (-2.9A);SAH A 401 (-3.6A);SAH A 401 (-2.4A)","0.95A","3g89B-6cu5A:9.0","3g89B-6cu5A:undetectable"],["3G8B_A_SAMA303_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE G","6cu5","PROTEIN ARGININE N-METHYLTRANSFERASE","Naegleria fowleri",5,"GLY A  51;GLY A  53;ASP A  73;GLU A 102;ARG A  27","SAH A 401 (-3.1A);SAH A 401 ( 4.0A);SAH A 401 (-2.9A);SAH A 401 (-3.6A);SAH A 401 (-2.4A)","0.95A","3g8bA-6cu5A:9.2","3g8bA-6cu5A:undetectable"],["3G8B_B_SAMB303_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE G","6cu5","PROTEIN ARGININE N-METHYLTRANSFERASE","Naegleria fowleri",5,"GLY A  51;GLY A  53;ASP A  73;GLU A 102;ARG A  27","SAH A 401 (-3.1A);SAH A 401 ( 4.0A);SAH A 401 (-2.9A);SAH A 401 (-3.6A);SAH A 401 (-2.4A)","0.93A","3g8bB-6cu5A:8.0","3g8bB-6cu5A:undetectable"],["4QZT_C_RTLC201_0","RETINOL-BINDING PROTEIN 2","6cu5","PROTEIN ARGININE N-METHYLTRANSFERASE","Naegleria fowleri",5,"PHE A 125;ILE A 295;ALA A 245;LEU A 211;LEU A 127","None","1.49A","4qztC-6cu5A:undetectable","4qztC-6cu5A:undetectable"],["5KMF_A_6U9A1301_1","ION TRANSPORT PROTEIN;ION TRANSPORT PROTEIN","6cu5","PROTEIN ARGININE N-METHYLTRANSFERASE","Naegleria fowleri",4,"THR A 267;GLY A 264;TYR A 157;ILE A 158","None","0.93A","5kmfA-6cu5A:undetectable;5kmfC-6cu5A:undetectable","5kmfA-6cu5A:16.92;5kmfC-6cu5A:16.92"],["5KXI_A_NCTA402_1","NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4;NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2","6cu5","PROTEIN ARGININE N-METHYLTRANSFERASE","Naegleria fowleri",4,"CYH A 249;CYH A 154;TRP A 272;LEU A 126","None","1.22A","5kxiA-6cu5A:undetectable;5kxiB-6cu5A:undetectable","5kxiA-6cu5A:10.36;5kxiB-6cu5A:10.87"],["5KXI_D_NCTD402_1","NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4;NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2","6cu5","PROTEIN ARGININE N-METHYLTRANSFERASE","Naegleria fowleri",4,"CYH A 249;CYH A 154;TRP A 272;LEU A 126","None","1.23A","5kxiD-6cu5A:undetectable;5kxiE-6cu5A:undetectable","5kxiD-6cu5A:10.36;5kxiE-6cu5A:10.87"],["6CDU_B_EY4B500_0","CHIMERIC ALPHA1GABAA RECEPTOR","6cu5","PROTEIN ARGININE N-METHYLTRANSFERASE","Naegleria fowleri",4,"GLN A 274;VAL A 276;PRO A 265;ALA A 242","None","1.02A","6cduB-6cu5A:undetectable;6cduC-6cu5A:undetectable","6cduB-6cu5A:undetectable;6cduC-6cu5A:undetectable"]]