SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cv0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 6cv0 SPIKE GLYCOPROTEIN
(Avian
coronavirus) 		4 / 7 GLY A 560
ILE A 562
TYR A 525
GLY A 507
 None
 0.86A 11gsB-6cv0A:
undetectable		 11gsB-6cv0A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6cv0 SPIKE GLYCOPROTEIN
(Avian
coronavirus) 		3 / 3 VAL A 218
ALA A 208
HIS A  41
 None
 0.77A 1q23G-6cv0A:
undetectable		 1q23G-6cv0A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6cv0 SPIKE GLYCOPROTEIN
(Avian
coronavirus) 		3 / 3 VAL A 218
ALA A 208
HIS A  41
 None
 0.71A 1q23L-6cv0A:
undetectable		 1q23L-6cv0A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 6cv0 SPIKE GLYCOPROTEIN
(Avian
coronavirus) 		5 / 12 THR A 682
ALA A 756
ALA A 759
ILE A 677
PHE A 760
 None
 1.04A 2nyrA-6cv0A:
undetectable		 2nyrA-6cv0A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6cv0 SPIKE GLYCOPROTEIN
(Avian
coronavirus) 		4 / 7 TYR A 258
GLN A 410
TYR A 423
ILE A 426
 None
 1.21A 2ph9A-6cv0A:
undetectable
2ph9B-6cv0A:
undetectable		 2ph9A-6cv0A:
16.59
2ph9B-6cv0A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6cv0 SPIKE GLYCOPROTEIN
(Avian
coronavirus) 		3 / 3 VAL A 824
LYS A 827
HIS A 888
 None
 0.70A 3elzA-6cv0A:
1.3		 3elzA-6cv0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)		 6cv0 SPIKE GLYCOPROTEIN
(Avian
coronavirus) 		4 / 4 PHE A 190
LYS A 191
ILE A 196
THR A  99
 None
 1.27A 3ia4B-6cv0A:
undetectable		 3ia4B-6cv0A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 6cv0 SPIKE GLYCOPROTEIN
(Avian
coronavirus) 		3 / 3 ASN A 264
ASN A 422
GLU A 260
 None
 0.87A 3kpdB-6cv0A:
undetectable		 3kpdB-6cv0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 6cv0 SPIKE GLYCOPROTEIN
(Avian
coronavirus) 		5 / 12 THR A 154
ALA A 100
SER A  88
GLY A  89
ALA A  85
 None
 1.20A 3mg02-6cv0A:
undetectable
3mg0V-6cv0A:
undetectable		 3mg02-6cv0A:
18.38
3mg0V-6cv0A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 6cv0 SPIKE GLYCOPROTEIN
(Avian
coronavirus) 		5 / 11 THR A 154
ALA A 100
SER A  88
GLY A  89
ALA A  85
 None
 1.21A 3mg0N-6cv0A:
undetectable		 3mg0N-6cv0A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 6cv0 SPIKE GLYCOPROTEIN
(Avian
coronavirus) 		4 / 8 GLY A 560
ILE A 562
TYR A 525
GLY A 507
 None
 0.81A 3n9jB-6cv0A:
undetectable		 3n9jB-6cv0A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 6cv0 SPIKE GLYCOPROTEIN
(Avian
coronavirus) 		4 / 8 GLY A 365
SER A 361
TYR A 400
SER A 348
 None
 0.84A 3pwwA-6cv0A:
undetectable		 3pwwA-6cv0A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 6cv0 SPIKE GLYCOPROTEIN
(Avian
coronavirus) 		4 / 8 ASN A 129
GLN A 127
THR A 154
TRP A  92
 None
 1.34A 4d1yA-6cv0A:
undetectable
4d1yB-6cv0A:
undetectable		 4d1yA-6cv0A:
16.00
4d1yB-6cv0A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 6cv0 SPIKE GLYCOPROTEIN
(Avian
coronavirus) 		4 / 7 VAL A  49
SER A  23
LEU A 220
ASP A 222
 None
 1.16A 4hxyB-6cv0A:
undetectable		 4hxyB-6cv0A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 6cv0 SPIKE GLYCOPROTEIN
(Avian
coronavirus) 		3 / 3 LEU A 169
MET A  83
TYR A  30
 None
 0.78A 4p6xG-6cv0A:
undetectable		 4p6xG-6cv0A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 6cv0 SPIKE GLYCOPROTEIN
(Avian
coronavirus) 		3 / 3 LYS A 901
ARG A 778
VAL A 922
 None
 1.01A 4x3uA-6cv0A:
undetectable
4x3uB-6cv0A:
undetectable		 4x3uA-6cv0A:
18.75
4x3uB-6cv0A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6cv0 SPIKE GLYCOPROTEIN
(Avian
coronavirus) 		5 / 11 VAL A 183
GLY A  73
GLY A  72
ASN A  58
ILE A  70
 None
None
None
None
NAG  A1228 ( 4.3A)
 1.46A 4zvmA-6cv0A:
undetectable
4zvmB-6cv0A:
undetectable		 4zvmA-6cv0A:
14.67
4zvmB-6cv0A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 6cv0 SPIKE GLYCOPROTEIN
(Avian
coronavirus) 		3 / 3 PRO A 770
LEU A 681
SER A 671
 None
 0.59A 5fsaB-6cv0A:
undetectable		 5fsaB-6cv0A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 6cv0 SPIKE GLYCOPROTEIN
(Avian
coronavirus) 		5 / 11 ILE A 677
PHE A 771
VAL A 755
MET A 758
LEU A 923
 None
 1.43A 5jkwA-6cv0A:
undetectable		 5jkwA-6cv0A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 6cv0 SPIKE GLYCOPROTEIN
(Avian
coronavirus) 		5 / 12 THR A 154
ALA A 100
SER A  88
GLY A  89
ALA A  85
 None
 1.16A 5lf7V-6cv0A:
undetectable
5lf7b-6cv0A:
undetectable		 5lf7V-6cv0A:
undetectable
5lf7b-6cv0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 6cv0 SPIKE GLYCOPROTEIN
(Avian
coronavirus) 		5 / 12 THR A 154
ALA A 100
SER A  88
GLY A  89
ALA A  85
 None
 1.15A 5lf7H-6cv0A:
undetectable
5lf7N-6cv0A:
undetectable		 5lf7H-6cv0A:
undetectable
5lf7N-6cv0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 6cv0 SPIKE GLYCOPROTEIN
(Avian
coronavirus) 		4 / 7 PHE A 625
ARG A 873
ILE A 870
GLY A 872
 None
 0.94A 5nzyA-6cv0A:
undetectable		 5nzyA-6cv0A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 6cv0 SPIKE GLYCOPROTEIN
(Avian
coronavirus) 		3 / 3 PHE A 573
ARG A 920
ALA A 986
 None
 0.76A 6ecfB-6cv0A:
undetectable		 6ecfB-6cv0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 6cv0 SPIKE GLYCOPROTEIN
(Avian
coronavirus) 		4 / 5 ILE A 933
GLN A 600
THR A 601
LEU A 697
 None
 0.98A 6f3mD-6cv0A:
undetectable		 6f3mD-6cv0A:
10.75