SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cv6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 6cv6 3-DEHYDROQUINATE
DEHYDRATASE
(Paraburkholderia
phymatum) 		5 / 12 HIS A   8
LEU A  93
LEU A 100
LEU A  35
TYR A 133
 None
 1.30A 1fm6D-6cv6A:
undetectable		 1fm6D-6cv6A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 6cv6 3-DEHYDROQUINATE
DEHYDRATASE
(Paraburkholderia
phymatum) 		5 / 12 SER A  48
HIS A   8
LEU A  93
LEU A 100
LEU A  35
 None
 1.17A 1fm6D-6cv6A:
undetectable		 1fm6D-6cv6A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6cv6 3-DEHYDROQUINATE
DEHYDRATASE
(Paraburkholderia
phymatum) 		4 / 7 TRP A  79
CYH A  58
GLN A  50
ILE A  86
 None
 1.22A 2xz5A-6cv6A:
undetectable
2xz5B-6cv6A:
undetectable		 2xz5A-6cv6A:
undetectable
2xz5B-6cv6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 6cv6 3-DEHYDROQUINATE
DEHYDRATASE
(Paraburkholderia
phymatum) 		4 / 7 ILE A  10
GLY A   9
PHE A 117
ILE A  86
 None
 0.79A 2y7wC-6cv6A:
2.2		 2y7wC-6cv6A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 6cv6 3-DEHYDROQUINATE
DEHYDRATASE
(Paraburkholderia
phymatum) 		4 / 5 VAL A 120
VAL A 121
GLN A 143
PHE A  65
 None
 1.34A 3bjwB-6cv6A:
undetectable		 3bjwB-6cv6A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ACTA908_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 6cv6 3-DEHYDROQUINATE
DEHYDRATASE
(Paraburkholderia
phymatum) 		4 / 4 MET A   6
SER A  48
LEU A  35
VAL A  46
 None
 1.44A 3vlnA-6cv6A:
1.6		 3vlnA-6cv6A:
undetectable