SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cvq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6cvq APRATAXIN
(Homo
sapiens) 		3 / 3 SER A 174
ASP A 193
CYH A 272
 AMP  A 401 (-2.2A)
AMP  A 401 (-2.2A)
BME  A 404 (-2.7A)
 1.03A 2br4E-6cvqA:
undetectable		 2br4E-6cvqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 6cvq APRATAXIN
(Homo
sapiens) 		3 / 3 PRO A 206
LEU A 213
SER A 209
 None
 0.83A 5fsaB-6cvqA:
undetectable		 5fsaB-6cvqA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 6cvq APRATAXIN
(Homo
sapiens) 		3 / 3 PRO A 254
LEU A 203
SER A 212
 AMP  A 401 (-4.5A)
AMP  A 401 ( 4.7A)
None
 0.84A 5fsaB-6cvqA:
undetectable		 5fsaB-6cvqA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 6cvq APRATAXIN
(Homo
sapiens) 		5 / 12 ASP A 193
LEU A 203
SER A 255
HIS A 260
HIS A 262
 AMP  A 401 (-2.2A)
AMP  A 401 ( 4.7A)
NA  A 403 ( 2.4A)
AMP  A 401 (-3.8A)
AMP  A 401 (-4.0A)
 0.32A 5km9B-6cvqA:
11.6		 5km9B-6cvqA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 6cvq APRATAXIN
(Homo
sapiens) 		3 / 3 LYS A 338
HIS A 335
HIS A 339
 None
ZN  A 402 (-3.2A)
ZN  A 402 (-3.2A)
 1.15A 5oexA-6cvqA:
undetectable		 5oexA-6cvqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 6cvq APRATAXIN
(Homo
sapiens) 		3 / 3 LYS A 338
HIS A 335
HIS A 339
 None
ZN  A 402 (-3.2A)
ZN  A 402 (-3.2A)
 1.23A 5oexB-6cvqA:
undetectable		 5oexB-6cvqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 6cvq APRATAXIN
(Homo
sapiens) 		3 / 3 LYS A 338
HIS A 335
HIS A 339
 None
ZN  A 402 (-3.2A)
ZN  A 402 (-3.2A)
 1.20A 5oexC-6cvqA:
undetectable		 5oexC-6cvqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 6cvq APRATAXIN
(Homo
sapiens) 		3 / 3 LYS A 338
HIS A 335
HIS A 339
 None
ZN  A 402 (-3.2A)
ZN  A 402 (-3.2A)
 1.15A 5oexD-6cvqA:
undetectable		 5oexD-6cvqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 6cvq APRATAXIN
(Homo
sapiens) 		5 / 12 ILE A 191
ASP A 193
LEU A 203
HIS A 260
HIS A 262
 AMP  A 401 ( 4.3A)
AMP  A 401 (-2.2A)
AMP  A 401 ( 4.7A)
AMP  A 401 (-3.8A)
AMP  A 401 (-4.0A)
 0.29A 5uvmB-6cvqA:
10.6		 5uvmB-6cvqA:
24.00