SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cvz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 6cvz E3 UBIQUITIN-PROTEIN
LIGASE RFWD3
(Homo
sapiens) 		4 / 7 THR A 662
SER A 665
ARG A 664
LEU A 651
 None
 1.11A 1ibgL-6cvzA:
undetectable		 1ibgL-6cvzA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 6cvz E3 UBIQUITIN-PROTEIN
LIGASE RFWD3
(Homo
sapiens) 		5 / 11 LEU A 591
ALA A 538
ALA A 557
VAL A 607
LEU A 579
 None
 1.08A 1rlbF-6cvzA:
undetectable		 1rlbF-6cvzA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 6cvz E3 UBIQUITIN-PROTEIN
LIGASE RFWD3
(Homo
sapiens) 		5 / 12 GLY A 558
GLY A 562
ARG A 540
ALA A 516
GLU A 578
 None
 1.23A 2vdvE-6cvzA:
undetectable		 2vdvE-6cvzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 6cvz E3 UBIQUITIN-PROTEIN
LIGASE RFWD3
(Homo
sapiens) 		5 / 11 GLY A 558
GLY A 562
ARG A 540
ALA A 516
GLU A 578
 None
 1.23A 2vdvF-6cvzA:
undetectable		 2vdvF-6cvzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 6cvz E3 UBIQUITIN-PROTEIN
LIGASE RFWD3
(Homo
sapiens) 		4 / 5 ASP A 550
SER A 592
VAL A 607
GLY A 605
 None
 0.92A 3rxhA-6cvzA:
undetectable		 3rxhA-6cvzA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 6cvz E3 UBIQUITIN-PROTEIN
LIGASE RFWD3
(Homo
sapiens) 		4 / 8 TYR A 593
TYR A 556
TYR A 554
ARG A 570
 None
 1.42A 3wipB-6cvzA:
undetectable
3wipC-6cvzA:
undetectable		 3wipB-6cvzA:
undetectable
3wipC-6cvzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 6cvz E3 UBIQUITIN-PROTEIN
LIGASE RFWD3
(Homo
sapiens) 		4 / 8 TYR A 593
TYR A 556
TYR A 554
ARG A 570
 None
 1.40A 3wipD-6cvzA:
undetectable
3wipE-6cvzA:
undetectable		 3wipD-6cvzA:
undetectable
3wipE-6cvzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 6cvz E3 UBIQUITIN-PROTEIN
LIGASE RFWD3
(Homo
sapiens) 		4 / 4 THR A 643
GLY A 606
ASP A 550
SER A 592
 None
 1.39A 4rfqA-6cvzA:
undetectable		 4rfqA-6cvzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 6cvz E3 UBIQUITIN-PROTEIN
LIGASE RFWD3
(Homo
sapiens) 		5 / 6 LEU A 588
SER A 616
PRO A 628
PHE A 617
GLU A 619
 None
 1.49A 5b8iA-6cvzA:
undetectable		 5b8iA-6cvzA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 6cvz E3 UBIQUITIN-PROTEIN
LIGASE RFWD3
(Homo
sapiens) 		5 / 12 VAL A 580
GLU A 619
ALA A 609
LEU A 591
TYR A 554
 None
 1.45A 5igpA-6cvzA:
1.9		 5igpA-6cvzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 6cvz E3 UBIQUITIN-PROTEIN
LIGASE RFWD3
(Homo
sapiens) 		4 / 5 GLN A 466
VAL A 479
PRO A 469
THR A 531
 None
 1.23A 6cduI-6cvzA:
undetectable
6cduJ-6cvzA:
undetectable		 6cduI-6cvzA:
undetectable
6cduJ-6cvzA:
undetectable