SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cwo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 6cwo RIBONUCLEOTIDE
REDUCTASE
(Flavobacterium
johnsoniae) 		5 / 12 ALA A 199
GLU A  67
ILE A  66
ARG A 129
LEU A 133
 None
MN  A 401 (-2.0A)
None
None
None
 1.26A 1d1gA-6cwoA:
undetectable		 1d1gA-6cwoA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6cwo RIBONUCLEOTIDE
REDUCTASE
(Flavobacterium
johnsoniae) 		3 / 3 SER A 251
GLU A 250
GLU A  52
 None
 0.70A 1eqbD-6cwoA:
undetectable		 1eqbD-6cwoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6cwo RIBONUCLEOTIDE
REDUCTASE
(Flavobacterium
johnsoniae) 		3 / 3 SER A 251
GLU A 250
GLU A  52
 None
 0.69A 1eqbB-6cwoA:
undetectable		 1eqbB-6cwoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 6cwo RIBONUCLEOTIDE
REDUCTASE
(Flavobacterium
johnsoniae) 		5 / 11 GLU A  97
HIS A 100
GLU A 160
PHE A 168
GLU A 195
 MN  A 401 ( 2.6A)
MN  A 401 (-3.5A)
MN  A 402 (-2.5A)
None
MN  A 402 ( 2.1A)
 0.80A 1rnrA-6cwoA:
31.0		 1rnrA-6cwoA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 6cwo RIBONUCLEOTIDE
REDUCTASE
(Flavobacterium
johnsoniae) 		5 / 12 GLU A  97
HIS A 100
GLU A 160
PHE A 168
GLU A 195
 MN  A 401 ( 2.6A)
MN  A 401 (-3.5A)
MN  A 402 (-2.5A)
None
MN  A 402 ( 2.1A)
 0.79A 1rnrB-6cwoA:
31.2		 1rnrB-6cwoA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 6cwo RIBONUCLEOTIDE
REDUCTASE
(Flavobacterium
johnsoniae) 		5 / 12 GLU A  97
HIS A 100
TYR A 104
GLU A 160
GLU A 195
 MN  A 401 ( 2.6A)
MN  A 401 (-3.5A)
None
MN  A 402 (-2.5A)
MN  A 402 ( 2.1A)
 0.95A 1rnrB-6cwoA:
31.2		 1rnrB-6cwoA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 6cwo RIBONUCLEOTIDE
REDUCTASE
(Flavobacterium
johnsoniae) 		5 / 10 PHE A 177
ILE A 170
ASP A 256
LEU A 257
ILE A 252
 None
 1.14A 1yi4A-6cwoA:
undetectable		 1yi4A-6cwoA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6cwo RIBONUCLEOTIDE
REDUCTASE
(Flavobacterium
johnsoniae) 		4 / 7 TRP A  74
ASP A 139
THR A 140
TYR A 148
 None
 1.29A 2eikN-6cwoA:
undetectable
2eikP-6cwoA:
3.4		 2eikN-6cwoA:
undetectable
2eikP-6cwoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6cwo RIBONUCLEOTIDE
REDUCTASE
(Flavobacterium
johnsoniae) 		4 / 7 TRP A  74
ASP A 139
THR A 140
TYR A 148
 None
 1.28A 2eilN-6cwoA:
undetectable
2eilP-6cwoA:
2.9		 2eilN-6cwoA:
undetectable
2eilP-6cwoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 6cwo RIBONUCLEOTIDE
REDUCTASE
(Flavobacterium
johnsoniae) 		4 / 8 GLU A 160
ILE A 159
GLU A  67
ILE A  66
 MN  A 402 (-2.5A)
None
MN  A 401 (-2.0A)
None
 0.78A 2j9dJ-6cwoA:
undetectable
2j9dK-6cwoA:
undetectable
2j9dL-6cwoA:
undetectable		 2j9dJ-6cwoA:
undetectable
2j9dK-6cwoA:
undetectable
2j9dL-6cwoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 6cwo RIBONUCLEOTIDE
REDUCTASE
(Flavobacterium
johnsoniae) 		4 / 7 PHE A 155
ILE A 197
PHE A  93
GLU A  97
 None
None
None
MN  A 401 ( 2.6A)
 0.97A 2opxA-6cwoA:
undetectable		 2opxA-6cwoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6cwo RIBONUCLEOTIDE
REDUCTASE
(Flavobacterium
johnsoniae) 		4 / 6 PHE A  81
ILE A  77
GLY A 202
GLY A 201
 None
 0.62A 2qx6A-6cwoA:
undetectable
2qx6B-6cwoA:
undetectable		 2qx6A-6cwoA:
16.59
2qx6B-6cwoA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 6cwo RIBONUCLEOTIDE
REDUCTASE
(Flavobacterium
johnsoniae) 		5 / 12 LEU A 154
GLU A 236
MET A 261
ILE A 265
SER A 268
 None
 1.45A 2ydoA-6cwoA:
undetectable		 2ydoA-6cwoA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 6cwo RIBONUCLEOTIDE
REDUCTASE
(Flavobacterium
johnsoniae) 		4 / 5 GLN A 167
ALA A  62
GLN A  65
ILE A  63
 None
 1.21A 2z0aA-6cwoA:
undetectable		 2z0aA-6cwoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 6cwo RIBONUCLEOTIDE
REDUCTASE
(Flavobacterium
johnsoniae) 		5 / 12 TYR A 204
GLY A 202
ILE A 197
ASN A 200
ASP A 194
 None
 1.35A 2zznB-6cwoA:
undetectable		 2zznB-6cwoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 6cwo RIBONUCLEOTIDE
REDUCTASE
(Flavobacterium
johnsoniae) 		5 / 10 TYR A 204
GLY A 202
ILE A 197
ASN A 200
ASP A 194
 None
 1.27A 3ay0B-6cwoA:
undetectable		 3ay0B-6cwoA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S7S_A_EXMA601_1
(CYTOCHROME P450 19A1)		 6cwo RIBONUCLEOTIDE
REDUCTASE
(Flavobacterium
johnsoniae) 		5 / 9 ALA A  39
ASP A  40
THR A  41
VAL A 110
LEU A 107
 None
 1.22A 3s7sA-6cwoA:
undetectable		 3s7sA-6cwoA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 6cwo RIBONUCLEOTIDE
REDUCTASE
(Flavobacterium
johnsoniae) 		4 / 5 LEU A 154
LEU A 158
LEU A 133
SER A 134
 None
 1.00A 3vhuA-6cwoA:
2.8		 3vhuA-6cwoA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 6cwo RIBONUCLEOTIDE
REDUCTASE
(Flavobacterium
johnsoniae) 		3 / 3 ASN A 186
TRP A 190
ASP A  40
 None
 1.30A 4a7tA-6cwoA:
undetectable
4a7tF-6cwoA:
undetectable		 4a7tA-6cwoA:
15.69
4a7tF-6cwoA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 6cwo RIBONUCLEOTIDE
REDUCTASE
(Flavobacterium
johnsoniae) 		5 / 10 ALA A  39
ASP A  40
THR A  41
VAL A 110
LEU A 107
 None
 1.21A 4kq8A-6cwoA:
undetectable		 4kq8A-6cwoA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 6cwo RIBONUCLEOTIDE
REDUCTASE
(Flavobacterium
johnsoniae) 		4 / 8 TRP A  30
HIS A 100
TYR A  29
ILE A  25
 None
MN  A 401 (-3.5A)
None
None
 1.00A 4ms4A-6cwoA:
undetectable		 4ms4A-6cwoA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6cwo RIBONUCLEOTIDE
REDUCTASE
(Flavobacterium
johnsoniae) 		4 / 6 GLN A 167
PHE A 165
PHE A 291
LEU A 172
 None
 1.12A 5b1bC-6cwoA:
2.9
5b1bJ-6cwoA:
undetectable		 5b1bC-6cwoA:
undetectable
5b1bJ-6cwoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 6cwo RIBONUCLEOTIDE
REDUCTASE
(Flavobacterium
johnsoniae) 		3 / 3 LYS A 178
SER A 173
SER A 251
 None
 1.04A 6gbfA-6cwoA:
undetectable		 6gbfA-6cwoA:
undetectable