SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cwr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 6cwr -
(-) 		5 / 12 MET A  59
ALA A 175
ALA A 128
THR A 131
LEU A  68
 None
 1.23A 2x2nC-6cwrA:
undetectable		 2x2nC-6cwrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 6cwr -
(-) 		5 / 12 MET A  59
ALA A 175
ALA A 128
THR A 131
LEU A  68
 None
 1.24A 2x2nD-6cwrA:
undetectable		 2x2nD-6cwrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 6cwr -
(-) 		5 / 12 THR A 131
PHE A 165
ALA A 186
ALA A 159
THR A  31
 None
 1.29A 3dl9B-6cwrA:
undetectable		 3dl9B-6cwrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 6cwr -
(-) 		3 / 3 PHE A 185
LYS A 192
SER A 191
 None
 1.12A 3tyeB-6cwrA:
undetectable		 3tyeB-6cwrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 6cwr -
(-) 		5 / 9 VAL A 181
ALA A 178
THR A 176
VAL A 125
ALA A 128
 None
 1.33A 4oqrA-6cwrA:
undetectable		 4oqrA-6cwrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 6cwr -
(-) 		3 / 3 VAL A 133
TYR A 155
ALA A 158
 None
 0.54A 4ybnA-6cwrA:
undetectable		 4ybnA-6cwrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 6cwr -
(-) 		5 / 12 ALA A  41
GLY A  73
SER A  45
ASP A  36
ALA A  37
 None
 1.34A 5zvgA-6cwrA:
undetectable		 5zvgA-6cwrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 6cwr -
(-) 		5 / 12 ALA A  41
GLY A  73
SER A  45
ASP A  36
ALA A  37
 None
 1.33A 5zvgB-6cwrA:
undetectable		 5zvgB-6cwrA:
undetectable