SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cwx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 6cwx RIBONUCLEASE P
PROTEIN SUBUNIT P25
(Homo
sapiens) 		4 / 5 LEU B 135
SER B  44
LEU B  49
GLY B  69
 None
None
None
CME  B  70 ( 2.3A)
 1.09A 1a4lB-6cwxB:
undetectable		 1a4lB-6cwxB:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 6cwx RIBONUCLEASE P
PROTEIN SUBUNIT P25
(Homo
sapiens) 		4 / 6 LEU B 135
LEU B  97
ILE B 137
ARG B  96
 None
None
None
SO4  B 203 (-4.0A)
 1.00A 2rlfC-6cwxB:
undetectable
2rlfD-6cwxB:
undetectable		 2rlfC-6cwxB:
16.67
2rlfD-6cwxB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6cwx RIBONUCLEASE P
PROTEIN SUBUNIT P20
(Homo
sapiens) 		4 / 7 ILE A  37
TYR A  38
PRO A  31
HIS A 131
 CME  A  52 ( 3.6A)
None
None
None
 1.06A 4g5jA-6cwxA:
undetectable		 4g5jA-6cwxA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 6cwx RIBONUCLEASE P
PROTEIN SUBUNIT P20
(Homo
sapiens) 		5 / 12 ASN A 127
VAL A 105
ILE A  71
ILE A  82
ASN A  79
 None
None
None
None
CME  B  70 ( 4.9A)
 0.98A 4xueA-6cwxA:
undetectable		 4xueA-6cwxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 6cwx RIBONUCLEASE P
PROTEIN SUBUNIT P20
RIBONUCLEASE P
PROTEIN SUBUNIT P25
(Homo
sapiens) 		5 / 12 ALA A 100
THR A 102
THR B  95
LEU B  97
THR B  74
 None
None
None
None
CME  B  70 ( 4.3A)
 1.22A 4ypmA-6cwxA:
undetectable		 4ypmA-6cwxA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 6cwx RIBONUCLEASE P
PROTEIN SUBUNIT P20
(Homo
sapiens) 		3 / 3 ASP A  44
ASN A  83
GLN A  87
 None
FMT  A 201 (-3.9A)
None
 0.62A 5k7uA-6cwxA:
2.8		 5k7uA-6cwxA:
undetectable