SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cxd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 6cxd PEPTIDASE B
(Yersinia
pestis) 		4 / 8 GLU A 100
ARG A 104
LEU A  69
GLU A  70
 SO4  A 501 (-4.2A)
SO4  A 501 (-4.5A)
None
SO4  A 501 (-4.1A)
 0.76A 1cmaA-6cxdA:
undetectable
1cmaB-6cxdA:
undetectable		 1cmaA-6cxdA:
undetectable
1cmaB-6cxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6cxd PEPTIDASE B
(Yersinia
pestis) 		5 / 12 ALA A 304
ALA A 379
VAL A 164
ILE A 161
CYH A 247
 SO4  A 503 ( 4.5A)
None
None
None
None
 1.00A 1fm6U-6cxdA:
undetectable		 1fm6U-6cxdA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 6cxd PEPTIDASE B
(Yersinia
pestis) 		5 / 11 GLU A 100
ARG A 236
ARG A 104
LEU A  69
GLU A  70
 SO4  A 501 (-4.2A)
SO4  A 501 (-2.7A)
SO4  A 501 (-4.5A)
None
SO4  A 501 (-4.1A)
 1.28A 1mjlA-6cxdA:
undetectable
1mjlB-6cxdA:
undetectable		 1mjlA-6cxdA:
undetectable
1mjlB-6cxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 6cxd PEPTIDASE B
(Yersinia
pestis) 		5 / 12 LEU A 246
LEU A 175
ALA A 176
LEU A 135
CYH A 192
 None
 1.36A 2aa6A-6cxdA:
undetectable		 2aa6A-6cxdA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 6cxd PEPTIDASE B
(Yersinia
pestis) 		5 / 11 LEU A 427
VAL A 419
GLY A 418
ALA A 229
LEU A 232
 None
 1.14A 2bxgA-6cxdA:
undetectable		 2bxgA-6cxdA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 6cxd PEPTIDASE B
(Yersinia
pestis) 		4 / 6 ARG A 267
LEU A 174
GLU A 294
ILE A 290
 None
 1.03A 2fcnA-6cxdA:
undetectable
2fcnB-6cxdA:
undetectable		 2fcnA-6cxdA:
undetectable
2fcnB-6cxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 6cxd PEPTIDASE B
(Yersinia
pestis) 		5 / 12 ALA A 119
GLY A 123
ASN A 251
GLY A 195
LEU A 285
 None
 0.99A 2hw2A-6cxdA:
undetectable		 2hw2A-6cxdA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 6cxd PEPTIDASE B
(Yersinia
pestis) 		5 / 11 LEU A 425
ILE A 301
PHE A 343
ALA A 423
LEU A 226
 None
 1.15A 2qjuA-6cxdA:
undetectable		 2qjuA-6cxdA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 6cxd PEPTIDASE B
(Yersinia
pestis) 		5 / 11 LEU A 244
ILE A 301
ALA A 191
GLU A 339
LEU A 238
 None
None
None
SO4  A 501 (-2.7A)
None
 1.19A 2v0mA-6cxdA:
undetectable		 2v0mA-6cxdA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 6cxd PEPTIDASE B
(Yersinia
pestis) 		4 / 4 ARG A 104
GLN A  46
PHE A  75
LEU A 101
 SO4  A 501 (-4.5A)
None
None
None
 1.46A 3abkC-6cxdA:
undetectable		 3abkC-6cxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 6cxd PEPTIDASE B
(Yersinia
pestis) 		5 / 10 ARG A 104
GLY A  78
ALA A  49
ILE A  34
GLY A  44
 SO4  A 501 (-4.5A)
None
None
None
None
 1.03A 3el9B-6cxdA:
undetectable		 3el9B-6cxdA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 6cxd PEPTIDASE B
(Yersinia
pestis) 		3 / 3 LYS A 311
ILE A 198
PHE A 200
 None
 0.83A 3j7zS-6cxdA:
undetectable
3j7za-6cxdA:
undetectable		 3j7zS-6cxdA:
undetectable
3j7za-6cxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 6cxd PEPTIDASE B
(Yersinia
pestis) 		5 / 9 ILE A  34
ALA A  49
VAL A  88
PHE A  79
LEU A  62
 None
 1.18A 3ti1A-6cxdA:
undetectable		 3ti1A-6cxdA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6cxd PEPTIDASE B
(Yersinia
pestis) 		3 / 3 ASP A 397
ARG A 403
THR A 307
 None
None
SO4  A 503 (-4.6A)
 0.74A 4i13A-6cxdA:
undetectable		 4i13A-6cxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 6cxd PEPTIDASE B
(Yersinia
pestis) 		5 / 12 LEU A 244
THR A 305
ALA A 303
ILE A 301
ILE A 396
 None
 0.93A 4o2bB-6cxdA:
3.0		 4o2bB-6cxdA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6cxd PEPTIDASE B
(Yersinia
pestis) 		3 / 3 ASP A 397
ARG A 403
THR A 307
 None
None
SO4  A 503 (-4.6A)
 0.71A 4p3rA-6cxdA:
undetectable		 4p3rA-6cxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6cxd PEPTIDASE B
(Yersinia
pestis) 		5 / 9 THR A 225
ALA A 229
ALA A 233
ILE A 396
GLY A 418
 None
 1.16A 4qvqK-6cxdA:
undetectable
4qvqL-6cxdA:
undetectable		 4qvqK-6cxdA:
15.09
4qvqL-6cxdA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6cxd PEPTIDASE B
(Yersinia
pestis) 		5 / 9 THR A 225
ALA A 229
ALA A 233
ILE A 396
GLY A 418
 None
 1.16A 4qvqY-6cxdA:
undetectable
4qvqZ-6cxdA:
undetectable		 4qvqY-6cxdA:
15.09
4qvqZ-6cxdA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 6cxd PEPTIDASE B
(Yersinia
pestis) 		4 / 6 ALA A 331
GLN A 330
LEU A 328
LEU A 321
 None
 1.17A 4xoyA-6cxdA:
undetectable		 4xoyA-6cxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 6cxd PEPTIDASE B
(Yersinia
pestis) 		5 / 11 ILE A 115
ALA A 414
GLY A 413
GLY A  84
ASN A 116
 None
 1.00A 5ayfA-6cxdA:
undetectable		 5ayfA-6cxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 6cxd PEPTIDASE B
(Yersinia
pestis) 		5 / 12 LEU A 244
THR A 305
ALA A 303
ILE A 301
ILE A 396
 None
 0.94A 5mioB-6cxdA:
undetectable		 5mioB-6cxdA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 6cxd PEPTIDASE B
(Yersinia
pestis) 		5 / 12 ALA A 223
GLY A 228
GLY A 288
LEU A 382
LEU A 289
 None
 1.08A 5wwsA-6cxdA:
undetectable		 5wwsA-6cxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 6cxd PEPTIDASE B
(Yersinia
pestis) 		5 / 12 GLY A 281
GLY A 222
GLY A 197
ALA A 303
ASP A 302
 SO4  A 503 (-3.3A)
None
None
None
None
 1.23A 5x7fA-6cxdA:
undetectable		 5x7fA-6cxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 6cxd PEPTIDASE B
(Yersinia
pestis) 		4 / 5 LEU A 193
VAL A 242
GLU A 240
LEU A 426
 None
 0.85A 5xooB-6cxdA:
undetectable		 5xooB-6cxdA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 6cxd PEPTIDASE B
(Yersinia
pestis) 		5 / 11 GLU A 100
GLY A 228
ALA A 231
ALA A 229
VAL A 111
 SO4  A 501 (-4.2A)
None
None
None
None
 1.21A 5yk2A-6cxdA:
undetectable		 5yk2A-6cxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 6cxd PEPTIDASE B
(Yersinia
pestis) 		4 / 6 GLN A 355
GLU A 350
HIS A 384
ALA A 380
 None
None
SO4  A 502 (-3.7A)
None
 1.38A 6f6jC-6cxdA:
undetectable
6f6jD-6cxdA:
undetectable		 6f6jC-6cxdA:
undetectable
6f6jD-6cxdA:
undetectable