SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cxh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 VAL B  63
VAL B  61
TRP B  48
 None
 0.91A 1av2C-6cxhB:
undetectable
1av2D-6cxhB:
undetectable		 1av2C-6cxhB:
undetectable
1av2D-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 VAL A 200
TRP A 206
TRP B  87
 CM5  A 502 ( 4.9A)
None
None
 1.39A 1c4dA-6cxhA:
undetectable
1c4dB-6cxhA:
undetectable		 1c4dA-6cxhA:
undetectable
1c4dB-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
(Methylomicrobium
alcaliphilum) 		4 / 6 LEU B 167
ILE A 178
GLU A 176
PRO B 166
 None
 1.18A 1ditH-6cxhB:
undetectable
1ditP-6cxhB:
undetectable		 1ditH-6cxhB:
17.97
1ditP-6cxhB:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 THR B 191
PRO B 194
THR B 193
 None
 0.93A 1dscC-6cxhB:
undetectable		 1dscC-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 4 VAL B  61
TRP B 152
TRP B  60
 None
 1.34A 1gmkC-6cxhB:
undetectable
1gmkD-6cxhB:
undetectable		 1gmkC-6cxhB:
undetectable
1gmkD-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 TRP A 202
VAL A 200
TRP B  87
 None
CM5  A 502 ( 4.9A)
None
 1.30A 1gmkC-6cxhA:
undetectable
1gmkD-6cxhA:
undetectable		 1gmkC-6cxhA:
undetectable
1gmkD-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
(Methylomicrobium
alcaliphilum) 		4 / 6 PRO A 353
ASP A 395
ASN A 399
ASP A 397
 None
 1.41A 1hpkA-6cxhA:
undetectable		 1hpkA-6cxhA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 ASP A 382
LEU A 376
LEU A 379
 None
 0.34A 1ikeA-6cxhA:
undetectable		 1ikeA-6cxhA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 ASP A 382
LEU A 376
LEU A 379
 None
 0.35A 1np1B-6cxhA:
undetectable		 1np1B-6cxhA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		4 / 6 TYR B 186
ILE A 105
PHE A  88
ARG A 100
 None
 1.46A 1oniA-6cxhB:
undetectable
1oniC-6cxhB:
undetectable		 1oniA-6cxhB:
undetectable
1oniC-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
(Methylomicrobium
alcaliphilum) 		5 / 10 GLN A 108
VAL A 110
ILE A 105
TYR A 122
GLY A 271
 None
 1.38A 1pn0C-6cxhA:
undetectable		 1pn0C-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
(Methylomicrobium
alcaliphilum) 		5 / 10 GLN A 108
VAL A 110
ILE A 105
TYR A 122
GLY A 271
 None
 1.37A 1pn0D-6cxhA:
undetectable		 1pn0D-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA8_0
(GRAMICIDIN A
MINI-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		4 / 4 VAL B  75
TRP B  81
TRP B  80
GLY B 235
 None
 1.35A 1tkqA-6cxhB:
undetectable
1tkqB-6cxhB:
undetectable		 1tkqA-6cxhB:
undetectable
1tkqB-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, C
SUBUNIT
(Methylomicrobium
alcaliphilum) 		4 / 7 TYR C 174
HIS C 106
LEU C 110
ILE C 234
 None
 1.16A 1tuvA-6cxhC:
undetectable		 1tuvA-6cxhC:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 VAL B  63
VAL B  61
TRP B  48
 None
 0.85A 1w5uC-6cxhB:
undetectable
1w5uD-6cxhB:
undetectable		 1w5uC-6cxhB:
undetectable
1w5uD-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
(Methylomicrobium
alcaliphilum) 		4 / 6 ARG A 100
GLY B 192
THR B 193
ARG B 190
 None
 1.08A 2f7fA-6cxhA:
undetectable		 2f7fA-6cxhA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 VAL B  61
TRP B  48
VAL B  63
 None
 0.84A 2izqA-6cxhB:
undetectable
2izqB-6cxhB:
undetectable		 2izqA-6cxhB:
undetectable
2izqB-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		4 / 7 PRO B 214
VAL B 215
SER B 216
GLU B 201
 None
 0.93A 2v41E-6cxhB:
undetectable
2v41F-6cxhB:
undetectable		 2v41E-6cxhB:
undetectable
2v41F-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 VAL B  75
TRP B  80
TRP B  81
 None
 1.03A 2xdcA-6cxhB:
undetectable
2xdcB-6cxhB:
undetectable		 2xdcA-6cxhB:
undetectable
2xdcB-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 VAL B  75
TRP B  81
TRP B  80
 None
 1.17A 2xdcA-6cxhB:
undetectable
2xdcB-6cxhB:
undetectable		 2xdcA-6cxhB:
undetectable
2xdcB-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 VAL A 200
TRP A 202
TRP B  87
 CM5  A 502 ( 4.9A)
None
None
 1.35A 2xdcA-6cxhA:
undetectable
2xdcB-6cxhA:
undetectable		 2xdcA-6cxhA:
undetectable
2xdcB-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 VAL A 200
TRP A 206
TRP B  87
 CM5  A 502 ( 4.9A)
None
None
 1.23A 2xdcA-6cxhA:
undetectable
2xdcB-6cxhA:
undetectable		 2xdcA-6cxhA:
undetectable
2xdcB-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 TRP B  80
VAL B  75
TRP B  81
 None
 1.18A 2xdcA-6cxhB:
undetectable
2xdcB-6cxhB:
undetectable		 2xdcA-6cxhB:
undetectable
2xdcB-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 TRP B  81
VAL B  75
TRP B  80
 None
 1.04A 2xdcA-6cxhB:
undetectable
2xdcB-6cxhB:
undetectable		 2xdcA-6cxhB:
undetectable
2xdcB-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 TRP B  87
VAL A 200
TRP A 202
 None
CM5  A 502 ( 4.9A)
None
 1.34A 2xdcA-6cxhB:
undetectable
2xdcB-6cxhB:
undetectable		 2xdcA-6cxhB:
undetectable
2xdcB-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 TRP B  87
VAL A 200
TRP A 206
 None
CM5  A 502 ( 4.9A)
None
 1.22A 2xdcA-6cxhB:
undetectable
2xdcB-6cxhB:
undetectable		 2xdcA-6cxhB:
undetectable
2xdcB-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 VAL B  75
TRP B  80
TRP B  81
 None
 0.92A 2xdcC-6cxhB:
undetectable
2xdcD-6cxhB:
undetectable		 2xdcC-6cxhB:
undetectable
2xdcD-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 TRP B  81
VAL B  75
TRP B  80
 None
 0.75A 2xdcC-6cxhB:
undetectable
2xdcD-6cxhB:
undetectable		 2xdcC-6cxhB:
undetectable
2xdcD-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 TRP B  81
VAL B  75
TRP B  80
 None
 0.75A 2xdcE-6cxhB:
undetectable
2xdcF-6cxhB:
undetectable		 2xdcE-6cxhB:
undetectable
2xdcF-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 TRP A 202
VAL A 200
TRP A 206
 None
CM5  A 502 ( 4.9A)
None
 1.35A 2xdcE-6cxhA:
undetectable
2xdcF-6cxhA:
undetectable		 2xdcE-6cxhA:
undetectable
2xdcF-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 VAL B  75
TRP B  80
TRP B  81
 None
 1.03A 2y5mA-6cxhB:
undetectable
2y5mB-6cxhB:
undetectable		 2y5mA-6cxhB:
undetectable
2y5mB-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 VAL B  75
TRP B  81
TRP B  80
 None
 1.19A 2y5mA-6cxhB:
undetectable
2y5mB-6cxhB:
undetectable		 2y5mA-6cxhB:
undetectable
2y5mB-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 VAL A 200
TRP A 202
TRP B  87
 CM5  A 502 ( 4.9A)
None
None
 1.33A 2y5mA-6cxhA:
undetectable
2y5mB-6cxhA:
undetectable		 2y5mA-6cxhA:
undetectable
2y5mB-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 VAL A 200
TRP A 206
TRP B  87
 CM5  A 502 ( 4.9A)
None
None
 1.23A 2y5mA-6cxhA:
undetectable
2y5mB-6cxhA:
undetectable		 2y5mA-6cxhA:
undetectable
2y5mB-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 TRP B  81
VAL B  75
TRP B  80
 None
 0.75A 2y5mE-6cxhB:
undetectable
2y5mF-6cxhB:
undetectable		 2y5mE-6cxhB:
undetectable
2y5mF-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 VAL B  75
TRP B  80
TRP B  81
 None
 1.03A 2y6nA-6cxhB:
undetectable
2y6nB-6cxhB:
undetectable		 2y6nA-6cxhB:
undetectable
2y6nB-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 VAL B  75
TRP B  81
TRP B  80
 None
 1.18A 2y6nA-6cxhB:
undetectable
2y6nB-6cxhB:
undetectable		 2y6nA-6cxhB:
undetectable
2y6nB-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 VAL A 200
TRP A 202
TRP B  87
 CM5  A 502 ( 4.9A)
None
None
 1.33A 2y6nA-6cxhA:
undetectable
2y6nB-6cxhA:
undetectable		 2y6nA-6cxhA:
undetectable
2y6nB-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 VAL A 200
TRP A 206
TRP B  87
 CM5  A 502 ( 4.9A)
None
None
 1.22A 2y6nA-6cxhA:
undetectable
2y6nB-6cxhA:
undetectable		 2y6nA-6cxhA:
undetectable
2y6nB-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 TRP B  80
VAL B  75
TRP B  81
 None
 1.17A 2y6nA-6cxhB:
undetectable
2y6nB-6cxhB:
undetectable		 2y6nA-6cxhB:
undetectable
2y6nB-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 TRP B  81
VAL B  75
TRP B  80
 None
 1.04A 2y6nA-6cxhB:
undetectable
2y6nB-6cxhB:
undetectable		 2y6nA-6cxhB:
undetectable
2y6nB-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 TRP B  87
VAL A 200
TRP A 202
 None
CM5  A 502 ( 4.9A)
None
 1.32A 2y6nA-6cxhB:
undetectable
2y6nB-6cxhB:
undetectable		 2y6nA-6cxhB:
undetectable
2y6nB-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 TRP B  87
VAL A 200
TRP A 206
 None
CM5  A 502 ( 4.9A)
None
 1.21A 2y6nA-6cxhB:
undetectable
2y6nB-6cxhB:
undetectable		 2y6nA-6cxhB:
undetectable
2y6nB-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 TRP B  81
VAL B  75
TRP B  80
 None
 0.72A 2y6nC-6cxhB:
undetectable
2y6nD-6cxhB:
undetectable		 2y6nC-6cxhB:
undetectable
2y6nD-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 TRP B  81
VAL B  75
TRP B  80
 None
 0.73A 2y6nE-6cxhB:
undetectable
2y6nF-6cxhB:
undetectable		 2y6nE-6cxhB:
undetectable
2y6nF-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, C
SUBUNIT
(Methylomicrobium
alcaliphilum) 		5 / 12 TYR C 113
VAL C 186
SER C 226
GLY B  35
ILE C 117
 None
 1.39A 3a65A-6cxhC:
undetectable		 3a65A-6cxhC:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
(Methylomicrobium
alcaliphilum) 		4 / 8 GLY B 185
ILE A  91
MET A 141
PHE A  88
 None
 0.82A 3ko0B-6cxhB:
undetectable
3ko0J-6cxhB:
1.1		 3ko0B-6cxhB:
20.75
3ko0J-6cxhB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
(Methylomicrobium
alcaliphilum) 		4 / 8 GLY B 185
ILE A  91
MET A 141
PHE A  88
 None
 0.86A 3ko0K-6cxhB:
1.1
3ko0S-6cxhB:
1.1		 3ko0K-6cxhB:
20.75
3ko0S-6cxhB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 VAL B  63
VAL B  61
TRP B  48
 None
 0.81A 3l8lC-6cxhB:
undetectable
3l8lD-6cxhB:
undetectable		 3l8lC-6cxhB:
undetectable
3l8lD-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
(Methylomicrobium
alcaliphilum) 		5 / 11 PRO A 280
ALA A 315
PHE A 392
PHE A  50
ILE A 394
 None
 1.32A 3n23A-6cxhA:
undetectable		 3n23A-6cxhA:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, C
SUBUNIT
(Methylomicrobium
alcaliphilum) 		4 / 8 LEU B  34
TYR C 118
PHE B  31
TYR A 196
 None
 1.14A 3po7A-6cxhB:
undetectable		 3po7A-6cxhB:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
(Methylomicrobium
alcaliphilum) 		5 / 11 THR B  52
LEU A 180
GLU A 181
VAL B 189
PHE B 114
 None
 1.29A 3tbgA-6cxhB:
undetectable		 3tbgA-6cxhB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		4 / 6 ASP B 182
GLY B 185
ASP B  53
THR B  52
 None
 1.14A 3vqrA-6cxhB:
undetectable		 3vqrA-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		4 / 5 ASP B 182
GLY B 185
ASP B  53
THR B  52
 None
 1.16A 3vqrB-6cxhB:
undetectable		 3vqrB-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 VAL B  75
TRP B  80
TRP B  81
 None
 0.80A 3zq8A-6cxhB:
undetectable
3zq8B-6cxhB:
undetectable		 3zq8A-6cxhB:
undetectable
3zq8B-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 VAL A 200
TRP A 206
TRP B  87
 CM5  A 502 ( 4.9A)
None
None
 1.32A 3zq8A-6cxhA:
undetectable
3zq8B-6cxhA:
undetectable		 3zq8A-6cxhA:
undetectable
3zq8B-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 TRP A 202
VAL A 200
TRP A 206
 None
CM5  A 502 ( 4.9A)
None
 1.10A 3zq8A-6cxhA:
undetectable
3zq8B-6cxhA:
undetectable		 3zq8A-6cxhA:
undetectable
3zq8B-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1480_0
(MJ0495-LIKE PROTEIN)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, C
SUBUNIT
(Methylomicrobium
alcaliphilum) 		4 / 4 LYS C  90
GLU C  98
ILE C  94
SER C  93
 None
 1.45A 4ac9C-6cxhC:
undetectable		 4ac9C-6cxhC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		5 / 9 ILE B 129
GLY B 127
THR B  90
GLN B  76
GLY B  88
 None
 1.28A 4acaB-6cxhB:
undetectable
4acaC-6cxhB:
undetectable		 4acaB-6cxhB:
undetectable
4acaC-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1480_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, C
SUBUNIT
(Methylomicrobium
alcaliphilum) 		4 / 4 LYS C  90
GLU C  98
ILE C  94
SER C  93
 None
 1.40A 4acaC-6cxhC:
undetectable		 4acaC-6cxhC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1480_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, C
SUBUNIT
(Methylomicrobium
alcaliphilum) 		4 / 4 LYS C  90
GLU C  98
ILE C  94
SER C  93
 None
 1.37A 4acbC-6cxhC:
undetectable		 4acbC-6cxhC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
(Methylomicrobium
alcaliphilum) 		4 / 6 LEU A 376
LEU A 340
VAL A 322
ARG A  43
 None
 1.21A 4uswA-6cxhA:
undetectable		 4uswA-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, C
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		4 / 6 TYR B  83
GLY C 239
GLU B 241
ASN C 235
 None
 1.32A 4zbqA-6cxhB:
undetectable		 4zbqA-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, C
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		4 / 8 ASN C 235
ARG A 216
HIS C 103
THR C 173
 None
 1.27A 5db5A-6cxhC:
undetectable
5db5B-6cxhC:
undetectable		 5db5A-6cxhC:
undetectable
5db5B-6cxhC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DL9_A_ACTA214_0
(LYSOZYME C)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
(Methylomicrobium
alcaliphilum) 		4 / 5 GLU A 396
ASP A 397
VAL A 312
ALA A 311
 None
 1.48A 5dl9A-6cxhA:
undetectable		 5dl9A-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum) 		4 / 5 SER B  68
VAL B  67
GLY B  45
ALA B  64
 None
 0.96A 5k50A-6cxhB:
undetectable		 5k50A-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 HIS A 139
HIS A 137
HIS A  33
 CU  A 501 (-3.2A)
CU  A 501 (-3.1A)
CU  A 501 (-3.5A)
 1.00A 5oexA-6cxhA:
undetectable		 5oexA-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
(Methylomicrobium
alcaliphilum) 		5 / 12 SER A 113
TRP B  54
PRO B 194
ALA A 266
GLY A 267
 None
 1.08A 5tzoA-6cxhA:
undetectable		 5tzoA-6cxhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
(Methylomicrobium
alcaliphilum) 		5 / 12 SER A 113
TRP B  54
PRO B 194
ALA A 266
GLY A 267
 None
 1.08A 5tzoC-6cxhA:
undetectable		 5tzoC-6cxhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, C
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 SER C 163
HIS C 106
TYR C 174
 None
 0.98A 5y2tA-6cxhC:
undetectable		 5y2tA-6cxhC:
undetectable