SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6cyz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		4 / 8 GLU A  59
GLY A  56
SER A  97
ILE A  94
 None
None
ANP  A 401 (-2.8A)
None
 0.86A 1jg4A-6cyzA:
undetectable		 1jg4A-6cyzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		4 / 7 SER A  18
ALA A  20
SER A 102
ALA A 104
 None
None
ANP  A 401 (-1.8A)
None
 0.99A 1k5qA-6cyzA:
undetectable
1k5qB-6cyzA:
undetectable		 1k5qA-6cyzA:
undetectable
1k5qB-6cyzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 12 VAL A 251
LEU A  22
LEU A 272
ALA A 270
ALA A 267
 None
 1.15A 1sa1A-6cyzA:
undetectable
1sa1B-6cyzA:
undetectable		 1sa1A-6cyzA:
11.42
1sa1B-6cyzA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 12 VAL A 251
LEU A  22
LEU A 272
ALA A 270
ALA A 267
 None
 1.17A 1sa1C-6cyzA:
undetectable
1sa1D-6cyzA:
undetectable		 1sa1C-6cyzA:
11.42
1sa1D-6cyzA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		4 / 5 LEU A  22
ALA A  20
LEU A  29
SER A  28
 None
 1.08A 1tt6B-6cyzA:
undetectable		 1tt6B-6cyzA:
27.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 12 GLY A  80
GLY A  79
VAL A 130
LEU A 118
LEU A 131
 None
 1.27A 1ya4B-6cyzA:
undetectable		 1ya4B-6cyzA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 11 LEU A  62
VAL A  88
ILE A  72
VAL A  52
VAL A  50
 None
 1.09A 2nnpB-6cyzA:
undetectable		 2nnpB-6cyzA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		4 / 8 LEU A 279
THR A 276
ALA A 262
ALA A 261
 None
 1.01A 3ax9B-6cyzA:
2.6		 3ax9B-6cyzA:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 12 GLN A 238
ASP A  27
ASP A 143
ALA A  20
SER A  18
 None
 1.15A 3d91B-6cyzA:
undetectable		 3d91B-6cyzA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 12 LEU A 221
GLY A  23
GLY A  25
LEU A 236
ALA A 231
 None
 1.06A 3i5uA-6cyzA:
undetectable		 3i5uA-6cyzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 12 LEU A 221
GLY A  23
GLY A  25
LEU A 236
ALA A 231
 None
 1.09A 3i5uB-6cyzA:
undetectable		 3i5uB-6cyzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 10 PRO A 269
LEU A 100
SER A  19
ILE A 184
PRO A 185
 None
 1.36A 3ijxB-6cyzA:
undetectable
3ijxD-6cyzA:
undetectable		 3ijxB-6cyzA:
16.67
3ijxD-6cyzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_D_HCZD800_1
(GLUTAMATE RECEPTOR 2)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 9 ILE A 184
PRO A 185
PRO A 269
LEU A 100
SER A  19
 None
 1.30A 3ijxB-6cyzA:
undetectable
3ijxD-6cyzA:
undetectable		 3ijxB-6cyzA:
16.67
3ijxD-6cyzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 10 PRO A 269
LEU A 100
SER A  19
ILE A 184
PRO A 185
 None
 1.44A 3iluB-6cyzA:
undetectable
3iluE-6cyzA:
undetectable		 3iluB-6cyzA:
16.67
3iluE-6cyzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		4 / 7 VAL A 305
VAL A  41
ASN A 115
GLY A 116
 None
 1.13A 3kmoB-6cyzA:
undetectable		 3kmoB-6cyzA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 9 LEU A  29
PRO A  24
LEU A  22
THR A 232
LEU A 228
 None
 1.46A 3q1eB-6cyzA:
undetectable
3q1eD-6cyzA:
undetectable		 3q1eB-6cyzA:
25.00
3q1eD-6cyzA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 11 GLY A 101
GLY A 268
SER A 265
ALA A 182
ALA A 183
 ANP  A 401 ( 4.2A)
None
None
None
None
 0.86A 3sufC-6cyzA:
undetectable		 3sufC-6cyzA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 9 ALA A 169
THR A 170
GLY A 152
GLY A 151
ASP A 128
 None
 1.07A 4qvmK-6cyzA:
undetectable
4qvmL-6cyzA:
undetectable		 4qvmK-6cyzA:
19.00
4qvmL-6cyzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 10 ALA A 169
THR A 170
GLY A 152
GLY A 151
ASP A 128
 None
 1.05A 4qvpK-6cyzA:
undetectable
4qvpL-6cyzA:
undetectable		 4qvpK-6cyzA:
19.00
4qvpL-6cyzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 10 ALA A 169
THR A 170
GLY A 152
GLY A 151
ASP A 128
 None
 1.05A 4qvpY-6cyzA:
undetectable
4qvpZ-6cyzA:
undetectable		 4qvpY-6cyzA:
19.00
4qvpZ-6cyzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 11 ALA A 169
THR A 170
GLY A 152
GLY A 151
ASP A 128
 None
 1.07A 4qvwK-6cyzA:
undetectable
4qvwL-6cyzA:
undetectable		 4qvwK-6cyzA:
18.50
4qvwL-6cyzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 11 ALA A 169
THR A 170
GLY A 152
GLY A 151
ASP A 128
 None
 1.08A 4qvwY-6cyzA:
undetectable
4qvwZ-6cyzA:
undetectable		 4qvwY-6cyzA:
18.50
4qvwZ-6cyzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 10 ALA A 169
THR A 170
GLY A 152
GLY A 151
ASP A 128
 None
 1.06A 4qw1Y-6cyzA:
undetectable
4qw1Z-6cyzA:
undetectable		 4qw1Y-6cyzA:
19.00
4qw1Z-6cyzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 9 ALA A 169
THR A 170
GLY A 152
GLY A 151
ASP A 128
 None
 1.07A 5d0xK-6cyzA:
undetectable
5d0xL-6cyzA:
undetectable		 5d0xK-6cyzA:
19.00
5d0xL-6cyzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 9 ALA A 169
THR A 170
GLY A 152
GLY A 151
ASP A 128
 None
 1.07A 5d0xY-6cyzA:
undetectable
5d0xZ-6cyzA:
undetectable		 5d0xY-6cyzA:
19.00
5d0xZ-6cyzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 9 LEU A  22
LEU A 217
ALA A 273
VAL A 260
MET A 229
 None
 1.50A 5g44A-6cyzA:
undetectable		 5g44A-6cyzA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 11 ALA A 169
THR A 170
GLY A 152
GLY A 151
ASP A 128
 None
 1.01A 5lf3K-6cyzA:
undetectable
5lf3L-6cyzA:
undetectable		 5lf3K-6cyzA:
18.63
5lf3L-6cyzA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 11 ALA A 169
THR A 170
GLY A 152
GLY A 151
ASP A 128
 None
 0.99A 5lf3Y-6cyzA:
undetectable
5lf3Z-6cyzA:
undetectable		 5lf3Y-6cyzA:
18.63
5lf3Z-6cyzA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 9 LEU A 255
ALA A 273
GLY A 259
MET A 229
THR A 232
 None
 1.31A 5w5vA-6cyzA:
undetectable		 5w5vA-6cyzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 12 VAL A  68
ILE A  39
VAL A  15
LEU A 131
ALA A 135
 None
 0.60A 6ajiA-6cyzA:
undetectable		 6ajiA-6cyzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 6cyz HOMOSERINE KINASE
(Mycobacteroides
abscessus) 		5 / 10 VAL A  68
LEU A  67
LEU A  48
GLY A 112
VAL A  88
 None
ANP  A 401 ( 4.4A)
None
None
None
 1.20A 6eu9B-6cyzA:
undetectable		 6eu9B-6cyzA:
17.78