SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6czs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 6czs -
(-) 		7 / 10 GLN A 135
GLY A 139
SER A 140
PHE A 144
SER A 145
ALA A 282
GLY A 183
 None
 1.29A 1stfE-6czsA:
28.5
1stfI-6czsA:
undetectable		 1stfE-6czsA:
undetectable
1stfI-6czsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 6czs -
(-) 		8 / 10 GLN A 135
GLY A 139
SER A 140
TRP A 142
PHE A 144
SER A 145
HIS A 281
ALA A 282
 None
 0.34A 1stfE-6czsA:
28.5
1stfI-6czsA:
undetectable		 1stfE-6czsA:
undetectable
1stfI-6czsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 6czs -
(-) 		3 / 3 ARG A  54
TYR A  46
LYS A  44
 None
None
SO4  A 409 ( 4.0A)
 1.07A 1uujB-6czsA:
undetectable		 1uujB-6czsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 6czs -
(-) 		4 / 7 GLN A 135
GLY A 139
HIS A 281
TRP A 303
 None
 0.43A 3ai8A-6czsA:
26.3		 3ai8A-6czsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 6czs -
(-) 		4 / 4 ASN A 320
ALA A 326
GLY A 323
THR A 275
 TRE  A 413 (-4.1A)
None
None
None
 1.25A 4bboC-6czsA:
undetectable		 4bboC-6czsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 6czs -
(-) 		3 / 3 ASP A 235
ARG A 111
TYR A 109
 SO4  A 407 (-2.8A)
SO4  A 408 ( 3.2A)
None
 1.00A 5a7mA-6czsA:
undetectable		 5a7mA-6czsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 6czs -
(-) 		3 / 3 ASP A 235
ARG A 111
TYR A 109
 SO4  A 407 (-2.8A)
SO4  A 408 ( 3.2A)
None
 0.98A 5a7mB-6czsA:
undetectable		 5a7mB-6czsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 6czs -
(-) 		4 / 4 LYS A 133
ASP A 171
GLU A 202
THR A 147
 None
 1.45A 5d4uA-6czsA:
undetectable		 5d4uA-6czsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 6czs -
(-) 		4 / 4 LYS A 133
ASP A 171
GLU A 202
THR A 147
 None
 1.47A 5d4uB-6czsA:
undetectable		 5d4uB-6czsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 6czs -
(-) 		4 / 4 LYS A 133
ASP A 171
GLU A 202
THR A 147
 None
 1.46A 5d4uC-6czsA:
undetectable		 5d4uC-6czsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 6czs -
(-) 		4 / 4 LYS A 133
ASP A 171
GLU A 202
THR A 147
 None
 1.45A 5d4uD-6czsA:
undetectable		 5d4uD-6czsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 6czs -
(-) 		3 / 3 GLU A  98
TRP A 142
ASN A 101
 NAG  A 401 (-3.8A)
None
NAG  A 401 (-1.9A)
 1.14A 5dv4A-6czsA:
undetectable		 5dv4A-6czsA:
undetectable