SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6czx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 ASN A 266
ILE A 406
SER A 364
ASN A 219
 LLP  A 265 ( 4.9A)
None
None
None
 1.25A 1h7xA-6czxA:
undetectable		 1h7xA-6czxA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 ASN A 266
ILE A 406
SER A 364
ASN A 219
 LLP  A 265 ( 4.9A)
None
None
None
 1.25A 1h7xB-6czxA:
undetectable		 1h7xB-6czxA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 ASN A 266
ILE A 406
SER A 364
ASN A 219
 LLP  A 265 ( 4.9A)
None
None
None
 1.26A 1h7xC-6czxA:
undetectable		 1h7xC-6czxA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 ASN A 266
ILE A 406
SER A 364
ASN A 219
 LLP  A 265 ( 4.9A)
None
None
None
 1.26A 1h7xD-6czxA:
undetectable		 1h7xD-6czxA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 ASN A  75
LEU A 418
ALA A  77
GLY A  79
PHE A 370
 None
None
None
LLP  A 265 ( 4.2A)
None
 1.44A 1l5rA-6czxA:
undetectable		 1l5rA-6czxA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 TYR A 407
SER A 405
THR A 221
ASN A 219
 LLP  A 265 ( 3.7A)
None
LLP  A 265 ( 2.9A)
None
 1.39A 1yvpA-6czxA:
undetectable		 1yvpA-6czxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 ASP A 341
TYR A 344
LYS A 360
 None
 1.03A 2othA-6czxA:
undetectable		 2othA-6czxA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 PRO A 369
VAL A 399
GLY A 400
MET A 402
 None
 1.09A 2qd3A-6czxA:
undetectable		 2qd3A-6czxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 329
LEU A 323
LEU A  83
PRO A  84
VAL A  87
 None
None
None
None
SO4  A 504 ( 4.1A)
 1.24A 2qd4A-6czxA:
undetectable		 2qd4A-6czxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 372
GLY A 401
VAL A 399
LEU A 393
PHE A 381
 None
 1.47A 3h52C-6czxA:
undetectable		 3h52C-6czxA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 SER A 303
SER A 302
HIS A 110
 None
 0.57A 3mzeA-6czxA:
undetectable		 3mzeA-6czxA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 TYR A 196
GLY A 169
VAL A 187
PHE A 202
PHE A 227
 SO4  A 503 (-4.5A)
None
None
None
None
 1.19A 3qowA-6czxA:
2.1		 3qowA-6czxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 THR A 197
GLY A 191
GLY A 169
HIS A 223
SER A 193
 None
 1.00A 3tkaA-6czxA:
3.2		 3tkaA-6czxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 GLY A 261
ILE A 274
VAL A 253
VAL A 251
 None
 0.83A 3ufnB-6czxA:
undetectable		 3ufnB-6czxA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 HIS A 215
LEU A 293
LEU A 141
ASP A 294
 None
None
None
SO4  A 501 ( 4.3A)
 1.12A 4aqlA-6czxA:
undetectable		 4aqlA-6czxA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 GLU A 135
TYR A 136
SER A 254
 None
 0.91A 4at0A-6czxA:
undetectable		 4at0A-6czxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 SER A 405
GLY A 224
MET A 402
GLY A 395
 None
 0.76A 4fo4B-6czxA:
undetectable		 4fo4B-6czxA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ILE A 382
PHE A 370
ARG A 403
ALA A 404
SER A 398
 None
 1.05A 5ih0A-6czxA:
undetectable		 5ih0A-6czxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 THR A 168
TRP A 189
PHE A 202
PRO A 231
 None
 1.13A 5v4vB-6czxA:
undetectable		 5v4vB-6czxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 PHE A 320
VAL A 105
PRO A 269
VAL A 319
 None
 1.33A 6ekzA-6czxA:
undetectable		 6ekzA-6czxA:
20.00