SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d0n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		5 / 10 ALA A 356
GLY A 354
GLU A 318
LEU A 240
PRO A 397
 None
 1.14A 1cmcA-6d0nA:
undetectable
1cmcB-6d0nA:
undetectable		 1cmcA-6d0nA:
undetectable
1cmcB-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		5 / 12 ILE A 285
GLY A 281
SER A  43
LEU A 157
LEU A  39
 None
 1.43A 1fm6X-6d0nA:
undetectable		 1fm6X-6d0nA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		4 / 6 PRO A 397
PHE A  83
GLU A  89
GLN A 399
 None
 1.11A 1l2iB-6d0nA:
undetectable		 1l2iB-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		5 / 12 ALA A 356
GLY A 354
GLU A 318
LEU A 240
PRO A 397
 None
 1.16A 1mjqI-6d0nA:
undetectable
1mjqJ-6d0nA:
undetectable		 1mjqI-6d0nA:
undetectable
1mjqJ-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		4 / 7 SER A  21
LEU A 169
HIS A 180
THR A 144
 None
None
DMU  A 501 ( 4.6A)
DMU  A 501 (-3.9A)
 1.14A 2f78A-6d0nA:
undetectable		 2f78A-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		4 / 6 GLY A 316
GLY A  78
PHE A  68
PHE A  64
 None
 1.01A 2qx6A-6d0nA:
undetectable
2qx6B-6d0nA:
undetectable		 2qx6A-6d0nA:
17.83
2qx6B-6d0nA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		5 / 9 ALA A 164
ALA A 188
GLY A  25
GLY A 149
ILE A 148
 None
 1.29A 2v7bA-6d0nA:
undetectable		 2v7bA-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		5 / 9 ALA A 164
ALA A 188
GLY A  25
GLY A 149
ILE A 148
 None
 1.28A 2v7bB-6d0nA:
undetectable		 2v7bB-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		4 / 8 TYR A 349
ILE A 366
LEU A 157
PHE A 154
 None
 0.82A 2vctA-6d0nA:
undetectable		 2vctA-6d0nA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		4 / 8 TYR A 349
ILE A 366
LEU A 157
PHE A 154
 None
 0.86A 2vctB-6d0nA:
undetectable		 2vctB-6d0nA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		4 / 8 TYR A 349
ILE A 366
LEU A 157
PHE A 154
 None
 0.89A 2vctC-6d0nA:
undetectable		 2vctC-6d0nA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		4 / 7 TYR A 349
ILE A 366
LEU A 157
PHE A 154
 None
 0.89A 2vctD-6d0nA:
undetectable		 2vctD-6d0nA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		4 / 9 ILE A 310
PHE A 236
ALA A 237
GLU A 241
 None
 0.72A 2vufA-6d0nA:
undetectable		 2vufA-6d0nA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		5 / 12 PHE A 111
GLY A 113
HIS A 109
ILE A  54
THR A 309
 None
 1.08A 3a25A-6d0nA:
undetectable		 3a25A-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		4 / 6 ILE A 364
ILE A 389
LEU A 376
PHE A 379
 None
DMU  A 502 ( 4.7A)
None
None
 1.13A 3adsA-6d0nA:
undetectable		 3adsA-6d0nA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		5 / 12 LEU A 124
GLY A 125
VAL A  23
LEU A  27
LEU A  97
 None
 1.02A 3cjtC-6d0nA:
undetectable		 3cjtC-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		5 / 9 PHE A 154
VAL A 122
GLY A 119
ILE A 395
TYR A 396
 None
 1.21A 3csjB-6d0nA:
undetectable		 3csjB-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		5 / 9 GLY A 153
ILE A  93
PHE A 100
PHE A  68
GLY A 119
 None
 1.25A 3ko0A-6d0nA:
0.3
3ko0C-6d0nA:
undetectable		 3ko0A-6d0nA:
24.24
3ko0C-6d0nA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_G_TFPG201_1
(PROTEIN S100-A4)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		5 / 9 GLY A 119
GLY A 153
ILE A  93
PHE A 100
PHE A  68
 None
 1.26A 3ko0F-6d0nA:
undetectable
3ko0G-6d0nA:
undetectable		 3ko0F-6d0nA:
24.24
3ko0G-6d0nA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI201_1
(PROTEIN S100-A4)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		5 / 9 GLY A 119
GLY A 153
ILE A  93
PHE A 100
PHE A  68
 None
 1.18A 3ko0H-6d0nA:
0.4
3ko0I-6d0nA:
0.3		 3ko0H-6d0nA:
24.24
3ko0I-6d0nA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		5 / 12 GLY A 153
VAL A  82
MET A  79
THR A 105
PHE A  35
 None
 1.39A 3mnoA-6d0nA:
undetectable		 3mnoA-6d0nA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		5 / 11 PHE A 353
PHE A 323
GLY A 317
GLY A 116
ILE A 310
 None
 1.27A 3owxA-6d0nA:
undetectable
3owxB-6d0nA:
undetectable		 3owxA-6d0nA:
18.61
3owxB-6d0nA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		5 / 10 PHE A 353
PHE A 167
ALA A 163
THR A 160
PHE A 323
 None
 1.48A 3t3qA-6d0nA:
1.9		 3t3qA-6d0nA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		5 / 12 ILE A 148
ALA A 152
ALA A 151
ALA A  28
LEU A 169
 None
 1.14A 3uvvB-6d0nA:
undetectable		 3uvvB-6d0nA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		4 / 7 ALA A 155
ALA A  28
ALA A 188
THR A 191
 None
 0.82A 4du2A-6d0nA:
undetectable		 4du2A-6d0nA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		4 / 7 ALA A 155
ALA A  28
ALA A 188
THR A 191
 None
 0.81A 4du2B-6d0nA:
undetectable		 4du2B-6d0nA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		4 / 6 LEU A 145
LYS A 140
LEU A  17
GLU A  13
 None
None
DMU  A 501 ( 4.8A)
None
 1.09A 4f3tA-6d0nA:
undetectable		 4f3tA-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		5 / 12 ALA A 188
GLY A 156
ALA A 155
ALA A 168
ILE A 148
 None
 1.04A 4nkxC-6d0nA:
undetectable		 4nkxC-6d0nA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		5 / 12 ALA A 188
GLY A 156
ALA A 155
ALA A 168
ILE A 148
 None
 1.06A 4nkxD-6d0nA:
undetectable		 4nkxD-6d0nA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		4 / 7 GLU A 318
THR A 306
THR A 282
LEU A  39
 None
 1.05A 4pfjA-6d0nA:
undetectable		 4pfjA-6d0nA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		4 / 7 LEU A 145
LYS A 140
LEU A  17
GLU A  13
 None
None
DMU  A 501 ( 4.8A)
None
 1.02A 4z4fA-6d0nA:
undetectable		 4z4fA-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		5 / 12 GLY A 317
GLY A 116
ILE A 310
PHE A 353
PHE A 323
 None
 1.21A 4zvmA-6d0nA:
undetectable
4zvmB-6d0nA:
undetectable		 4zvmA-6d0nA:
17.83
4zvmB-6d0nA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		4 / 5 GLU A 318
THR A 306
THR A 282
LEU A  39
 None
 1.26A 5axaA-6d0nA:
undetectable		 5axaA-6d0nA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		4 / 5 GLU A 318
THR A 306
THR A 282
LEU A  39
 None
 1.27A 5axaC-6d0nA:
undetectable		 5axaC-6d0nA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		5 / 12 GLY A 330
SER A 296
LEU A 301
GLY A 230
VAL A 352
 None
 1.05A 5i75A-6d0nA:
undetectable		 5i75A-6d0nA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA612_1
(PHIAB6 TAILSPIKE)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		4 / 4 VAL A 171
THR A 357
GLU A 318
GLU A 118
 None
 1.11A 5jsdA-6d0nA:
undetectable
5jsdB-6d0nA:
undetectable		 5jsdA-6d0nA:
9.16
5jsdB-6d0nA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		3 / 3 VAL A  82
GLU A 318
GLU A 118
 None
 0.66A 5jsdB-6d0nA:
undetectable
5jsdC-6d0nA:
undetectable		 5jsdB-6d0nA:
9.16
5jsdC-6d0nA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		4 / 4 GLU A 318
GLU A 118
VAL A 171
THR A 357
 None
 1.11A 5jsdA-6d0nA:
undetectable
5jsdC-6d0nA:
undetectable		 5jsdA-6d0nA:
9.16
5jsdC-6d0nA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		4 / 6 PHE A 388
LEU A 227
SER A 390
GLY A 230
 DMU  A 502 (-3.6A)
None
None
None
 1.08A 5o4yF-6d0nA:
undetectable		 5o4yF-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		3 / 3 HIS A 179
SER A 178
LYS A 176
 None
None
DMU  A 501 (-3.8A)
 1.36A 5os7A-6d0nA:
undetectable		 5os7A-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		4 / 4 GLU A 318
THR A 306
THR A 282
LEU A  39
 None
 1.31A 5v96A-6d0nA:
undetectable		 5v96A-6d0nA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		4 / 4 GLU A 318
THR A 306
THR A 282
LEU A  39
 None
 1.31A 5v96B-6d0nA:
undetectable		 5v96B-6d0nA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		4 / 4 GLU A 318
THR A 306
THR A 282
LEU A  39
 None
 1.30A 5v96C-6d0nA:
undetectable		 5v96C-6d0nA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		4 / 4 GLU A 318
THR A 306
THR A 282
LEU A  39
 None
 1.31A 5v96D-6d0nA:
undetectable		 5v96D-6d0nA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		5 / 12 ILE A 366
ALA A 362
THR A 359
ALA A 356
GLY A 230
 None
 1.03A 5veuA-6d0nA:
1.9		 5veuA-6d0nA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		4 / 6 LEU A 169
PHE A 361
PHE A 177
LEU A 182
 None
 1.18A 5x19P-6d0nA:
undetectable		 5x19P-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		5 / 11 GLY A  29
ASP A  32
ALA A 192
ILE A 128
VAL A  31
 None
 1.18A 5yk2A-6d0nA:
0.7		 5yk2A-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		5 / 12 HIS A 109
GLY A 153
PHE A 353
GLY A 116
MET A  79
 None
 1.20A 6brdB-6d0nA:
undetectable		 6brdB-6d0nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		3 / 3 HIS A 179
SER A 178
LYS A 176
 None
None
DMU  A 501 (-3.8A)
 1.36A 6gmdB-6d0nA:
undetectable		 6gmdB-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER
(Enterococcus
casseliflavus) 		5 / 10 THR A 282
GLY A 116
GLY A 319
GLU A 118
PHE A  35
 None
 1.08A 6nqaK-6d0nA:
undetectable		 6nqaK-6d0nA:
undetectable