SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d0s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 6d0s TBC1 DOMAIN FAMILY
MEMBER 22B
(Homo
sapiens) 		5 / 12 CYH A 445
TYR A 430
MET A 410
LEU A 418
LEU A 485
 None
 1.38A 1fm6D-6d0sA:
undetectable		 1fm6D-6d0sA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 6d0s TBC1 DOMAIN FAMILY
MEMBER 22B
(Homo
sapiens) 		5 / 12 CYH A 445
TYR A 430
MET A 410
LEU A 418
LEU A 485
 None
 1.35A 1fm6X-6d0sA:
undetectable		 1fm6X-6d0sA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 6d0s TBC1 DOMAIN FAMILY
MEMBER 22B
(Homo
sapiens) 		4 / 6 TRP A 220
LEU A 222
LEU A 193
VAL A 211
 None
 1.18A 2dqyC-6d0sA:
1.8		 2dqyC-6d0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 6d0s TBC1 DOMAIN FAMILY
MEMBER 22B
(Homo
sapiens) 		4 / 4 ARG A 425
GLN A 431
PHE A 437
LEU A 486
 None
 1.06A 3abkC-6d0sA:
undetectable		 3abkC-6d0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6d0s TBC1 DOMAIN FAMILY
MEMBER 22B
(Homo
sapiens) 		4 / 7 MET A 355
LEU A 359
PRO A 317
MET A 415
 None
 0.94A 3hcnA-6d0sA:
undetectable		 3hcnA-6d0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6d0s TBC1 DOMAIN FAMILY
MEMBER 22B
(Homo
sapiens) 		5 / 12 CYH A 445
TYR A 430
MET A 410
LEU A 418
LEU A 485
 None
 1.37A 4emaA-6d0sA:
undetectable		 4emaA-6d0sA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6d0s TBC1 DOMAIN FAMILY
MEMBER 22B
(Homo
sapiens) 		4 / 6 GLN A 284
PRO A 280
PHE A 282
PHE A 291
 None
 1.27A 4fgkA-6d0sA:
undetectable		 4fgkA-6d0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 6d0s TBC1 DOMAIN FAMILY
MEMBER 22B
(Homo
sapiens) 		3 / 3 ARG A 216
TRP A 220
ILE A 424
 UNX  A 611 ( 4.2A)
None
None
 0.94A 4mwxA-6d0sA:
undetectable		 4mwxA-6d0sA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 6d0s TBC1 DOMAIN FAMILY
MEMBER 22B
(Homo
sapiens) 		5 / 12 GLY A 483
GLU A 480
ALA A 489
PHE A 440
VAL A 444
 None
 1.08A 4u8yB-6d0sA:
undetectable		 4u8yB-6d0sA:
5.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6d0s TBC1 DOMAIN FAMILY
MEMBER 22B
(Homo
sapiens) 		5 / 12 CYH A 445
TYR A 430
MET A 410
LEU A 418
LEU A 485
 None
 1.39A 5y2oA-6d0sA:
undetectable		 5y2oA-6d0sA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6d0s TBC1 DOMAIN FAMILY
MEMBER 22B
(Homo
sapiens) 		5 / 12 CYH A 445
TYR A 430
MET A 410
LEU A 418
LEU A 485
 None
 1.41A 5ycpA-6d0sA:
undetectable		 5ycpA-6d0sA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 6d0s TBC1 DOMAIN FAMILY
MEMBER 22B
(Homo
sapiens) 		5 / 9 PHE A 319
VAL A 320
LEU A 358
ARG A 216
ASP A 428
 None
None
None
UNX  A 611 ( 4.2A)
None
 1.46A 6c2mC-6d0sA:
undetectable		 6c2mC-6d0sA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6d0s TBC1 DOMAIN FAMILY
MEMBER 22B
(Homo
sapiens) 		4 / 6 ARG A 425
GLN A 431
PHE A 437
LEU A 486
 None
 0.99A 6nmpC-6d0sA:
undetectable
6nmpJ-6d0sA:
undetectable		 6nmpC-6d0sA:
undetectable
6nmpJ-6d0sA:
undetectable