SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d1w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)
6d1w POLYCYSTIN-2
(Homo
sapiens)
4 / 5 ALA A 647
ILE A 649
ASN A 645
ILE A 644
None
0.86A 2h4jA-6d1wA:
undetectable
2h4jA-6d1wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)
6d1w POLYCYSTIN-2
(Homo
sapiens)
3 / 3 LEU A 374
ASN A 547
ARG A 320
NAG  A 803 (-4.1A)
None
NAG  A 803 ( 4.3A)
0.91A 2qhfA-6d1wA:
undetectable
2qhfA-6d1wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
6d1w POLYCYSTIN-2
(Homo
sapiens)
4 / 8 THR A 260
GLN A 255
ARG A 251
SER A 286
None
0.92A 2xytE-6d1wA:
undetectable
2xytE-6d1wA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
6d1w POLYCYSTIN-2
(Homo
sapiens)
4 / 8 THR A 260
GLN A 255
ARG A 251
SER A 286
None
0.95A 2xytH-6d1wA:
undetectable
2xytH-6d1wA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)
6d1w POLYCYSTIN-2
(Homo
sapiens)
3 / 3 ARG A 440
ASP A 394
ASN A 547
None
0.80A 2zzmA-6d1wA:
undetectable
2zzmA-6d1wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))
6d1w POLYCYSTIN-2
(Homo
sapiens)
4 / 8 PRO A 319
VAL A 318
ASN A 543
GLN A 405
None
1.04A 4iilA-6d1wA:
undetectable
4iilA-6d1wA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)
6d1w POLYCYSTIN-2
(Homo
sapiens)
5 / 12 LEU A 256
LEU A 441
CYH A 437
LEU A 291
SER A 286
None
1.21A 4zbrA-6d1wA:
3.3
4zbrA-6d1wA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_NPSA602_1
(SERUM ALBUMIN)
6d1w POLYCYSTIN-2
(Homo
sapiens)
5 / 12 LEU A 256
LEU A 441
CYH A 437
LEU A 291
SER A 286
None
1.15A 5dbyA-6d1wA:
2.8
5dbyA-6d1wA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)
6d1w POLYCYSTIN-2
(Homo
sapiens)
4 / 7 GLN A 630
ILE A 382
GLN A 456
TYR A 386
None
0.96A 5vlmC-6d1wA:
undetectable
5vlmC-6d1wA:
undetectable