SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d21'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 6d21 FERM, RHOGEF AND
PLECKSTRIN DOMAIN
PROTEIN 2
(Danio
rerio) 		4 / 7 ASP A 154
PHE A 131
SER A 127
ARG A 125
 None
 1.01A 1rqpB-6d21A:
undetectable		 1rqpB-6d21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 6d21 FERM, RHOGEF AND
PLECKSTRIN DOMAIN
PROTEIN 2
(Danio
rerio) 		4 / 8 ASP A 154
PHE A 131
SER A 127
ARG A 125
 None
 1.00A 1rqpC-6d21A:
undetectable		 1rqpC-6d21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 6d21 FERM, RHOGEF AND
PLECKSTRIN DOMAIN
PROTEIN 2
(Danio
rerio) 		4 / 8 ASP A 154
PHE A 131
SER A 127
ARG A 125
 None
 1.01A 1rqpA-6d21A:
undetectable		 1rqpA-6d21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 6d21 FERM, RHOGEF AND
PLECKSTRIN DOMAIN
PROTEIN 2
(Danio
rerio) 		4 / 8 ASP A 154
PHE A 131
SER A 127
ARG A 125
 None
 0.98A 2v7uA-6d21A:
undetectable		 2v7uA-6d21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 6d21 FERM, RHOGEF AND
PLECKSTRIN DOMAIN
PROTEIN 2
(Danio
rerio) 		4 / 7 ASP A 154
PHE A 131
SER A 127
ARG A 125
 None
 1.01A 2v7uB-6d21A:
undetectable		 2v7uB-6d21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6d21 FERM, RHOGEF AND
PLECKSTRIN DOMAIN
PROTEIN 2
(Danio
rerio) 		5 / 11 GLN A  74
ASP A 107
VAL A 104
PHE A 130
ILE A 315
 None
 1.33A 3n23A-6d21A:
undetectable		 3n23A-6d21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6d21 FERM, RHOGEF AND
PLECKSTRIN DOMAIN
PROTEIN 2
(Danio
rerio) 		5 / 12 LEU A 197
LEU A 155
LEU A 160
LYS A 206
ILE A 207
 None
 1.23A 4f4dB-6d21A:
undetectable		 4f4dB-6d21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 6d21 FERM, RHOGEF AND
PLECKSTRIN DOMAIN
PROTEIN 2
(Danio
rerio) 		5 / 11 LEU A 123
GLY A  57
LEU A  58
GLN A  56
SER A 127
 None
 1.07A 4wnuA-6d21A:
undetectable		 4wnuA-6d21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 6d21 FERM, RHOGEF AND
PLECKSTRIN DOMAIN
PROTEIN 2
(Danio
rerio) 		5 / 11 LEU A 123
GLY A  57
LEU A  58
GLN A  56
SER A 127
 None
 1.02A 4wnuC-6d21A:
undetectable		 4wnuC-6d21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6d21 FERM, RHOGEF AND
PLECKSTRIN DOMAIN
PROTEIN 2
(Danio
rerio) 		4 / 5 SER A 172
ALA A 171
HIS A 173
LEU A 169
 None
 1.44A 5dzkb-6d21A:
undetectable
5dzkp-6d21A:
undetectable		 5dzkb-6d21A:
undetectable
5dzkp-6d21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6d21 FERM, RHOGEF AND
PLECKSTRIN DOMAIN
PROTEIN 2
(Danio
rerio) 		4 / 5 SER A 172
ALA A 171
HIS A 214
LEU A 169
 None
 1.24A 5dzkb-6d21A:
undetectable
5dzkp-6d21A:
undetectable		 5dzkb-6d21A:
undetectable
5dzkp-6d21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6d21 FERM, RHOGEF AND
PLECKSTRIN DOMAIN
PROTEIN 2
(Danio
rerio) 		4 / 5 SER A 172
ALA A 171
HIS A 173
LEU A 169
 None
 1.48A 5dzkc-6d21A:
undetectable
5dzkq-6d21A:
undetectable		 5dzkc-6d21A:
undetectable
5dzkq-6d21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6d21 FERM, RHOGEF AND
PLECKSTRIN DOMAIN
PROTEIN 2
(Danio
rerio) 		4 / 5 SER A 172
ALA A 171
HIS A 214
LEU A 169
 None
 1.26A 5dzkc-6d21A:
undetectable
5dzkq-6d21A:
undetectable		 5dzkc-6d21A:
undetectable
5dzkq-6d21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 6d21 FERM, RHOGEF AND
PLECKSTRIN DOMAIN
PROTEIN 2
(Danio
rerio) 		3 / 3 MET A 235
HIS A 266
GLY A 158
 None
 0.82A 5gwzB-6d21A:
undetectable		 5gwzB-6d21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJD_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 6d21 FERM, RHOGEF AND
PLECKSTRIN DOMAIN
PROTEIN 2
(Danio
rerio) 		5 / 9 LEU A 233
ILE A 207
ILE A 229
GLN A 200
LEU A 197
 None
 1.16A 5ljdA-6d21A:
undetectable		 5ljdA-6d21A:
undetectable