SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d2k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 6d2k FERM, ARHGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		5 / 11 PHE A 309
GLY A 252
ILE A 282
LEU A 273
PHE A 280
 None
 1.03A 1z11A-6d2kA:
undetectable		 1z11A-6d2kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 6d2k FERM, ARHGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		5 / 11 PHE A 309
GLY A 252
ILE A 282
LEU A 273
PHE A 280
 None
 1.04A 1z11B-6d2kA:
undetectable		 1z11B-6d2kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 6d2k FERM, ARHGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		5 / 10 PHE A 309
GLY A 252
ILE A 282
LEU A 273
PHE A 280
 None
 0.97A 1z11C-6d2kA:
undetectable		 1z11C-6d2kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 6d2k FERM, ARHGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		5 / 10 PHE A 309
GLY A 252
ILE A 282
LEU A 273
PHE A 280
 None
 1.05A 1z11D-6d2kA:
undetectable		 1z11D-6d2kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 6d2k FERM, ARHGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		5 / 12 THR A 159
ALA A 160
LEU A 153
LEU A 148
LEU A 226
 None
 0.97A 3hm1A-6d2kA:
undetectable		 3hm1A-6d2kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 6d2k FERM, ARHGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		4 / 7 PHE A 319
TYR A  84
PRO A 128
PHE A 140
 None
 1.30A 4grqA-6d2kA:
undetectable
4grqC-6d2kA:
undetectable		 4grqA-6d2kA:
undetectable
4grqC-6d2kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6d2k FERM, ARHGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		5 / 12 LEU A 281
ILE A 282
PHE A 280
LEU A 300
VAL A 253
 None
 1.11A 4k6iA-6d2kA:
undetectable		 4k6iA-6d2kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 6d2k FERM, ARHGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		3 / 3 GLU A 150
TRP A  96
LYS A 145
 None
 1.44A 4k7aA-6d2kA:
undetectable		 4k7aA-6d2kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 6d2k FERM, ARHGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2
(Mus
musculus) 		4 / 6 PHE A 124
LEU A 220
PRO A 128
ARG A 232
 None
 1.43A 4yv5A-6d2kA:
undetectable		 4yv5A-6d2kA:
undetectable