SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d2l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Homo
sapiens) 		5 / 9 LEU A 294
LEU A 387
ILE A 452
PHE A 374
ILE A 372
 None
 0.90A 2f78A-6d2lA:
undetectable		 2f78A-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Homo
sapiens) 		5 / 9 LEU A 294
LEU A 387
ILE A 452
PHE A 374
ILE A 372
 None
 0.94A 2f78B-6d2lA:
undetectable		 2f78B-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Homo
sapiens) 		5 / 9 LEU A 294
LEU A 387
ILE A 452
PHE A 374
ILE A 372
 None
 0.96A 2f7aA-6d2lA:
undetectable		 2f7aA-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Homo
sapiens) 		5 / 9 LEU A 294
LEU A 387
ILE A 452
PHE A 374
ILE A 372
 None
 0.86A 2f7aB-6d2lA:
undetectable		 2f7aB-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Homo
sapiens) 		5 / 10 LEU A 294
LEU A 387
ILE A 452
PHE A 374
ILE A 372
 None
 0.93A 2f8dA-6d2lA:
undetectable		 2f8dA-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Homo
sapiens) 		5 / 10 LEU A 294
LEU A 387
ILE A 452
PHE A 374
ILE A 372
 None
 0.90A 2f8dB-6d2lA:
undetectable		 2f8dB-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Homo
sapiens) 		4 / 7 PRO A 296
LEU A 434
ALA A 428
PHE A 427
 None
 0.97A 2vcvL-6d2lA:
undetectable		 2vcvL-6d2lA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Homo
sapiens) 		5 / 12 ILE A 197
GLY A 192
GLY A 194
SER A 195
ALA A 215
 FTG  A 501 (-4.7A)
FTG  A 501 (-3.2A)
FTG  A 501 ( 3.9A)
None
FTG  A 501 (-3.4A)
 1.11A 2yvlA-6d2lA:
10.7		 2yvlA-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Homo
sapiens) 		5 / 9 ALA A 203
VAL A 188
ILE A 197
ALA A 212
ILE A 210
 None
None
FTG  A 501 (-4.7A)
None
None
 1.05A 3ektB-6d2lA:
undetectable		 3ektB-6d2lA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Homo
sapiens) 		5 / 11 GLY A 192
GLY A 194
ALA A 215
GLU A 243
ARG A 168
 FTG  A 501 (-3.2A)
FTG  A 501 ( 3.9A)
FTG  A 501 (-3.4A)
FTG  A 501 (-3.2A)
FTG  A 501 (-3.3A)
 0.78A 3g88A-6d2lA:
9.1		 3g88A-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Homo
sapiens) 		5 / 11 GLY A 192
GLY A 194
ALA A 215
GLU A 243
ARG A 168
 FTG  A 501 (-3.2A)
FTG  A 501 ( 3.9A)
FTG  A 501 (-3.4A)
FTG  A 501 (-3.2A)
FTG  A 501 (-3.3A)
 0.80A 3g88B-6d2lA:
9.4		 3g88B-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Homo
sapiens) 		5 / 12 GLY A 192
GLY A 194
ALA A 215
GLU A 243
ARG A 168
 FTG  A 501 (-3.2A)
FTG  A 501 ( 3.9A)
FTG  A 501 (-3.4A)
FTG  A 501 (-3.2A)
FTG  A 501 (-3.3A)
 0.82A 3g89A-6d2lA:
9.8		 3g89A-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Homo
sapiens) 		5 / 11 GLY A 192
GLY A 194
ALA A 215
GLU A 243
ARG A 168
 FTG  A 501 (-3.2A)
FTG  A 501 ( 3.9A)
FTG  A 501 (-3.4A)
FTG  A 501 (-3.2A)
FTG  A 501 (-3.3A)
 0.83A 3g89B-6d2lA:
9.5		 3g89B-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Homo
sapiens) 		5 / 12 GLY A 192
GLY A 194
ALA A 215
GLU A 243
ARG A 168
 FTG  A 501 (-3.2A)
FTG  A 501 ( 3.9A)
FTG  A 501 (-3.4A)
FTG  A 501 (-3.2A)
FTG  A 501 (-3.3A)
 0.83A 3g8bA-6d2lA:
9.6		 3g8bA-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Homo
sapiens) 		5 / 12 GLY A 192
GLY A 194
ALA A 215
GLU A 243
ARG A 168
 FTG  A 501 (-3.2A)
FTG  A 501 ( 3.9A)
FTG  A 501 (-3.4A)
FTG  A 501 (-3.2A)
FTG  A 501 (-3.3A)
 0.84A 3g8bB-6d2lA:
9.2		 3g8bB-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Homo
sapiens) 		4 / 6 GLY A 194
GLU A 214
ASP A 190
GLU A 243
 FTG  A 501 ( 3.9A)
FTG  A 501 (-2.5A)
None
FTG  A 501 (-3.2A)
 0.78A 3vywC-6d2lA:
7.0		 3vywC-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Homo
sapiens) 		5 / 12 TYR A 355
GLY A 290
HIS A 293
ASP A 291
GLY A 260
 None
None
SO4  A 502 ( 4.8A)
None
FTG  A 501 ( 4.3A)
 1.14A 4blvA-6d2lA:
8.1		 4blvA-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Homo
sapiens) 		4 / 6 ILE A 372
PRO A 373
PHE A 374
PHE A 376
 None
 0.96A 4fgkA-6d2lA:
undetectable		 4fgkA-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Homo
sapiens) 		3 / 3 LYS A 280
PRO A 281
SER A 282
 None
 0.21A 4k50I-6d2lA:
undetectable		 4k50I-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Homo
sapiens) 		5 / 10 PHE A 359
VAL A 292
ASP A 291
TYR A 355
GLY A 290
 None
 1.31A 4xp1A-6d2lA:
undetectable		 4xp1A-6d2lA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Homo
sapiens) 		5 / 12 PHE A 335
PHE A 422
LEU A 434
THR A 459
GLY A 460
 None
 1.33A 4zjlA-6d2lA:
undetectable		 4zjlA-6d2lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 6d2l HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Homo
sapiens) 		5 / 12 GLY A 192
GLY A 194
LEU A 198
ALA A 215
GLU A 243
 FTG  A 501 (-3.2A)
FTG  A 501 ( 3.9A)
None
FTG  A 501 (-3.4A)
FTG  A 501 (-3.2A)
 0.84A 5c0oE-6d2lA:
10.4		 5c0oE-6d2lA:
undetectable