SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d34'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 6d34 TERC
(Streptomyces) 		5 / 12 LEU A 120
ASP A 173
GLY A 100
HIS A  90
PHE A 180
 None
IPA  A 202 ( 3.6A)
None
IPA  A 201 (-3.5A)
IPA  A 201 ( 3.5A)
 1.48A 1d4fC-6d34A:
undetectable		 1d4fC-6d34A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 6d34 TERC
(Streptomyces) 		5 / 12 LEU A 120
ASP A 173
LEU A 113
HIS A  90
PHE A 180
 None
IPA  A 202 ( 3.6A)
None
IPA  A 201 (-3.5A)
IPA  A 201 ( 3.5A)
 1.31A 1d4fC-6d34A:
undetectable		 1d4fC-6d34A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 6d34 TERC
(Streptomyces) 		4 / 8 TRP A 161
MET A 171
ARG A 143
ILE A 174
 None
IPA  A 202 ( 4.1A)
IPA  A 201 (-2.8A)
None
 1.45A 3e7gC-6d34A:
undetectable
3e7gD-6d34A:
undetectable		 3e7gC-6d34A:
10.86
3e7gD-6d34A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6d34 TERC
(Streptomyces) 		5 / 12 ILE A  75
GLY A  81
ALA A  62
SER A  66
GLY A  69
 None
 1.07A 4e1gA-6d34A:
undetectable		 4e1gA-6d34A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6d34 TERC
(Streptomyces) 		5 / 12 ILE A  75
GLY A  81
ALA A  62
SER A  66
GLY A  69
 None
 1.07A 4e1gB-6d34A:
undetectable		 4e1gB-6d34A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 6d34 TERC
(Streptomyces) 		4 / 8 ASP A 173
VAL A 116
LEU A 125
HIS A  90
 IPA  A 202 ( 3.6A)
IPA  A 201 ( 4.4A)
IPA  A 202 ( 4.4A)
IPA  A 201 (-3.5A)
 1.21A 4f5zA-6d34A:
undetectable		 4f5zA-6d34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 6d34 TERC
(Streptomyces) 		3 / 3 TRP A 161
GLN A 133
THR A 162
 None
 1.03A 4m2xA-6d34A:
undetectable		 4m2xA-6d34A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 6d34 TERC
(Streptomyces) 		4 / 7 PHE A  70
LEU A 125
MET A 123
MET A 171
 IPA  A 202 ( 4.4A)
IPA  A 202 ( 4.4A)
IPA  A 201 (-2.9A)
IPA  A 202 ( 4.1A)
 0.91A 4rjdB-6d34A:
undetectable		 4rjdB-6d34A:
11.11