SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d35'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		3 / 3 TRP A 254
ALA A 249
VAL A 294
 None
 0.97A 1av2C-6d35A:
undetectable
1av2D-6d35A:
undetectable		 1av2C-6d35A:
undetectable
1av2D-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		5 / 9 PHE A 428
THR A 501
VAL A 243
GLY A 301
VAL A 384
 None
 1.19A 1dz8A-6d35A:
undetectable		 1dz8A-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		5 / 9 PHE A 428
THR A 501
VAL A 243
GLY A 301
VAL A 384
 None
 1.15A 1dz8B-6d35A:
undetectable		 1dz8B-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		5 / 9 PHE A 428
THR A 501
VAL A 243
GLY A 301
VAL A 384
 None
 1.12A 1dz9B-6d35A:
undetectable		 1dz9B-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		4 / 6 ALA A 318
SER A1126
ARG A 234
LEU A 326
 None
 1.10A 1gahA-6d35A:
undetectable		 1gahA-6d35A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		5 / 10 PHE A 428
THR A 501
THR A 309
VAL A 384
VAL A 306
 None
 1.46A 1o76A-6d35A:
undetectable		 1o76A-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		5 / 9 PHE A 428
THR A 501
THR A 309
VAL A 384
VAL A 306
 None
 1.46A 1t86B-6d35A:
undetectable		 1t86B-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		3 / 3 TYR A 367
ARG A 263
GLN A 257
 None
 1.03A 1tw4A-6d35A:
undetectable		 1tw4A-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		5 / 11 GLY A 500
GLY A 502
SER A 504
PHE A 247
PHE A 305
 None
 1.13A 1w76A-6d35A:
undetectable		 1w76A-6d35A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		5 / 12 ALA A 468
ILE A 469
GLN A 165
LEU A  46
ILE A  50
 None
 1.04A 1xozA-6d35A:
undetectable		 1xozA-6d35A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		5 / 11 PHE A 428
THR A 501
GLY A 301
VAL A 384
VAL A 306
 None
 1.28A 2a1nA-6d35A:
undetectable		 2a1nA-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		5 / 11 PHE A 428
THR A 501
VAL A 243
GLY A 301
VAL A 384
 None
 1.13A 2a1nA-6d35A:
undetectable		 2a1nA-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		5 / 9 PHE A 428
THR A 501
VAL A 243
GLY A 301
VAL A 384
 None
 1.15A 2a1oB-6d35A:
undetectable		 2a1oB-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		5 / 10 PHE A 428
THR A 501
GLY A 301
VAL A 384
VAL A 306
 None
 1.25A 2cp4A-6d35A:
undetectable		 2cp4A-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		5 / 10 PHE A 428
THR A 501
VAL A 243
GLY A 301
VAL A 384
 None
 1.18A 2cp4A-6d35A:
undetectable		 2cp4A-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		3 / 3 ALA A 249
VAL A 294
TRP A 254
 None
 0.96A 2izqA-6d35A:
undetectable
2izqB-6d35A:
undetectable		 2izqA-6d35A:
undetectable
2izqB-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		5 / 10 PHE A 428
THR A 501
THR A 309
VAL A 384
VAL A 306
 None
 1.46A 2qboA-6d35A:
undetectable		 2qboA-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		4 / 7 TRP A 312
GLY A 301
GLY A 388
PHE A 428
 None
 0.98A 2qwxA-6d35A:
undetectable
2qwxB-6d35A:
undetectable		 2qwxA-6d35A:
20.11
2qwxB-6d35A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		5 / 9 PHE A 428
THR A 501
THR A 309
VAL A 384
VAL A 306
 None
 1.49A 3cppA-6d35A:
undetectable		 3cppA-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		4 / 7 TYR A 103
VAL A 102
PHE A 139
ILE A  95
 None
 0.95A 3zjqA-6d35A:
undetectable		 3zjqA-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		4 / 7 TYR A 103
VAL A 102
PHE A 139
ILE A  95
 None
 0.95A 3zjqB-6d35A:
undetectable		 3zjqB-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		5 / 12 PRO A 137
LEU A 140
TYR A 103
VAL A 102
SER A  69
 CLR  A1201 ( 4.8A)
None
None
None
None
 1.48A 4a84A-6d35A:
undetectable		 4a84A-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		5 / 12 LEU A  52
LEU A  99
LEU A  98
ALA A 101
ALA A  66
 None
 1.08A 4fn9A-6d35A:
undetectable		 4fn9A-6d35A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		3 / 3 ARG A1077
ASP A1054
ASP A1020
 None
 0.79A 4kicB-6d35A:
undetectable		 4kicB-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP9_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		5 / 12 TYR A 235
HIS A 334
CYH A 246
ALA A 245
ILE A 239
 None
 1.40A 4rp9A-6d35A:
0.5		 4rp9A-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		4 / 8 SER A 504
GLY A 502
ILE A 493
PHE A 247
 None
 0.83A 5alcL-6d35A:
undetectable		 5alcL-6d35A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		5 / 11 PHE A 364
VAL A 377
ILE A 381
ILE A 292
ILE A 293
 None
 1.07A 5hw8A-6d35A:
undetectable
5hw8D-6d35A:
undetectable		 5hw8A-6d35A:
19.20
5hw8D-6d35A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L7I_A_VISA1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		8 / 12 ASN A 192
ASP A 357
SER A 360
TYR A 367
GLN A 450
GLU A 491
ASN A 494
MET A 498
 None
 0.98A 5l7iA-6d35A:
39.8		 5l7iA-6d35A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L7I_A_VISA1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		8 / 12 ASN A 192
SER A 360
TYR A 367
GLN A 450
GLU A 491
ASN A 494
LEU A 495
MET A 498
 None
 0.88A 5l7iA-6d35A:
39.8		 5l7iA-6d35A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L7I_A_VISA1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		8 / 12 ASN A 192
TRP A 254
ASP A 357
SER A 360
TYR A 367
ARG A 373
GLU A 491
ASN A 494
 None
 0.92A 5l7iA-6d35A:
39.8		 5l7iA-6d35A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L7I_A_VISA1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		8 / 12 ASN A 192
TRP A 254
ASP A 357
SER A 360
TYR A 367
GLU A 491
ASN A 494
MET A 498
 None
 0.89A 5l7iA-6d35A:
39.8		 5l7iA-6d35A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L7I_A_VISA1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		8 / 12 ASN A 192
TRP A 254
SER A 360
TYR A 367
ARG A 373
GLU A 491
ASN A 494
LEU A 495
 None
 0.88A 5l7iA-6d35A:
39.8		 5l7iA-6d35A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L7I_A_VISA1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		8 / 12 ASN A 192
TRP A 254
SER A 360
TYR A 367
GLU A 491
ASN A 494
LEU A 495
MET A 498
 None
 0.81A 5l7iA-6d35A:
39.8		 5l7iA-6d35A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L7I_B_VISB1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		5 / 12 ASP A 357
SER A 360
TYR A 367
GLN A 450
MET A 298
 None
 1.43A 5l7iB-6d35A:
32.4		 5l7iB-6d35A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L7I_B_VISB1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		9 / 12 TRP A 254
ASP A 357
SER A 360
TYR A 367
ARG A 373
ASP A 446
PRO A 486
GLU A 491
ASN A 494
 None
 0.98A 5l7iB-6d35A:
32.4		 5l7iB-6d35A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L7I_B_VISB1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		10 / 12 TRP A 254
ASP A 357
SER A 360
TYR A 367
ASP A 446
GLN A 450
PRO A 486
GLU A 491
ASN A 494
MET A 498
 None
 0.91A 5l7iB-6d35A:
32.4		 5l7iB-6d35A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L7I_B_VISB1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		9 / 12 TRP A 254
SER A 360
TYR A 367
ARG A 373
ASP A 446
PRO A 486
GLU A 491
ASN A 494
LEU A 495
 None
 0.89A 5l7iB-6d35A:
32.4		 5l7iB-6d35A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L7I_B_VISB1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		10 / 12 TRP A 254
SER A 360
TYR A 367
ASP A 446
GLN A 450
PRO A 486
GLU A 491
ASN A 494
LEU A 495
MET A 498
 None
 0.77A 5l7iB-6d35A:
32.4		 5l7iB-6d35A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		4 / 7 LEU A 194
PHE A 195
SER A 358
GLU A 199
 None
 1.00A 5n5dA-6d35A:
undetectable		 5n5dA-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
(Escherichia
coli;
Xenopus
laevis) 		5 / 10 ALA A1050
LEU A1053
PHE A1080
ILE A1117
LEU A1025
 None
 1.42A 6h1lA-6d35A:
undetectable		 6h1lA-6d35A:
undetectable