SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d3i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 6d3i -
(-) 		5 / 12 TYR A 241
LEU A 236
LEU A 237
LEU A 150
ILE A 158
 None
 1.14A 1fmlA-6d3iA:
undetectable		 1fmlA-6d3iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 6d3i -
(-) 		5 / 12 TYR A 241
LEU A 236
LEU A 237
LEU A 150
ILE A 158
 None
 1.13A 1fmlB-6d3iA:
undetectable		 1fmlB-6d3iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 6d3i -
(-) 		4 / 8 HIS A 270
ILE A 106
HIS A 111
ASP A 113
 CO  A 301 (-3.2A)
AKG  A 302 (-4.6A)
CO  A 301 ( 3.2A)
CO  A 301 ( 2.5A)
 1.05A 2xadA-6d3iA:
undetectable		 2xadA-6d3iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 6d3i -
(-) 		4 / 8 HIS A 270
ILE A 106
HIS A 111
ASP A 113
 CO  A 301 (-3.2A)
AKG  A 302 (-4.6A)
CO  A 301 ( 3.2A)
CO  A 301 ( 2.5A)
 1.09A 2xadB-6d3iA:
undetectable		 2xadB-6d3iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 6d3i -
(-) 		4 / 8 HIS A 270
ILE A 106
HIS A 111
ASP A 113
 CO  A 301 (-3.2A)
AKG  A 302 (-4.6A)
CO  A 301 ( 3.2A)
CO  A 301 ( 2.5A)
 1.05A 2xadC-6d3iA:
undetectable		 2xadC-6d3iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 6d3i -
(-) 		4 / 8 HIS A 270
ILE A 106
HIS A 111
ASP A 113
 CO  A 301 (-3.2A)
AKG  A 302 (-4.6A)
CO  A 301 ( 3.2A)
CO  A 301 ( 2.5A)
 1.08A 2xadD-6d3iA:
undetectable		 2xadD-6d3iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 6d3i -
(-) 		5 / 12 MET A 126
VAL A  80
ASP A 113
TRP A 263
ILE A  95
 AKG  A 302 ( 4.5A)
None
CO  A 301 ( 2.5A)
None
AKG  A 302 (-4.2A)
 1.40A 3a65A-6d3iA:
undetectable		 3a65A-6d3iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 6d3i -
(-) 		4 / 5 TYR A 282
SER A  85
ASP A 258
ILE A  62
 None
 1.11A 3uj7B-6d3iA:
undetectable		 3uj7B-6d3iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 6d3i -
(-) 		5 / 12 THR A 115
ASN A 218
HIS A 111
GLY A 107
GLY A 195
 None
None
CO  A 301 ( 3.2A)
AKG  A 302 (-3.1A)
None
 1.25A 3v3oA-6d3iA:
undetectable		 3v3oA-6d3iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 6d3i -
(-) 		4 / 7 ALA A 156
ILE A 158
ARG A 213
GLY A 160
 None
 0.98A 3v4tH-6d3iA:
undetectable		 3v4tH-6d3iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6d3i -
(-) 		4 / 8 ILE A  95
ARG A 281
PRO A 121
VAL A 124
 AKG  A 302 (-4.2A)
AKG  A 302 (-3.1A)
None
None
 1.33A 4f4dB-6d3iA:
undetectable		 4f4dB-6d3iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6d3i -
(-) 		4 / 8 ILE A 106
ARG A 281
PRO A 121
VAL A 124
 AKG  A 302 (-4.6A)
AKG  A 302 (-3.1A)
None
None
 1.34A 4f4dB-6d3iA:
undetectable		 4f4dB-6d3iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 6d3i -
(-) 		4 / 8 ASP A 113
VAL A 170
LEU A  83
TYR A 221
 CO  A 301 ( 2.5A)
None
None
None
 1.15A 4f5zA-6d3iA:
undetectable		 4f5zA-6d3iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6d3i -
(-) 		4 / 7 GLN A  53
PHE A 140
ASN A 265
ASP A 264
 None
 1.40A 4kcnB-6d3iA:
undetectable		 4kcnB-6d3iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 6d3i -
(-) 		5 / 12 LEU A  83
GLY A 107
PHE A 171
THR A 168
HIS A 270
 None
AKG  A 302 (-3.1A)
None
None
CO  A 301 (-3.2A)
 1.36A 5d0yA-6d3iA:
undetectable		 5d0yA-6d3iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 6d3i -
(-) 		3 / 3 THR A 229
ASP A 230
ALA A 231
 None
 0.09A 5g5gB-6d3iA:
undetectable		 5g5gB-6d3iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6d3i -
(-) 		4 / 8 GLN A  53
PHE A 140
ASN A 265
ASP A 264
 None
 1.33A 5vunA-6d3iA:
undetectable		 5vunA-6d3iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6d3i -
(-) 		4 / 8 GLN A  53
PHE A 140
ASN A 265
ASP A 264
 None
 1.33A 6auuB-6d3iA:
undetectable		 6auuB-6d3iA:
undetectable