SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d43'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 6d43 TRIOSEPHOSPHATE
ISOMERASE
(Homo
sapiens) 		5 / 12 ILE B 243
PHE B 229
ALA B 221
ASN B 245
THR B  37
 None
 0.96A 2rlcA-6d43B:
undetectable		 2rlcA-6d43B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 6d43 TRIOSEPHOSPHATE
ISOMERASE
(Homo
sapiens) 		3 / 3 SER B   3
ARG B   4
GLN B 202
 None
 1.01A 2xnrA-6d43B:
undetectable		 2xnrA-6d43B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 6d43 TRIOSEPHOSPHATE
ISOMERASE
(Homo
sapiens) 		4 / 6 ARG B  17
ALA B  46
LEU B  21
PRO B  44
 None
 0.88A 3bgdA-6d43B:
1.2		 3bgdA-6d43B:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6d43 TRIOSEPHOSPHATE
ISOMERASE
(Homo
sapiens) 		4 / 8 THR B 213
GLY B 233
GLY B 232
VAL B 231
 None
 0.82A 4qvvK-6d43B:
undetectable
4qvvL-6d43B:
undetectable		 4qvvK-6d43B:
17.29
4qvvL-6d43B:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6d43 TRIOSEPHOSPHATE
ISOMERASE
(Homo
sapiens) 		4 / 8 THR B 213
GLY B 233
GLY B 232
VAL B 231
 None
 0.82A 4qvvY-6d43B:
undetectable
4qvvZ-6d43B:
undetectable		 4qvvY-6d43B:
17.29
4qvvZ-6d43B:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 6d43 TRIOSEPHOSPHATE
ISOMERASE
(Homo
sapiens) 		4 / 8 THR B 204
ASP B  36
VAL B  40
GLY B   9
 None
 0.91A 5nzyA-6d43B:
2.7		 5nzyA-6d43B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 6d43 TRIOSEPHOSPHATE
ISOMERASE
(Homo
sapiens) 		4 / 6 GLN B 182
GLU B 183
ALA B 181
GLN B 223
 None
 1.27A 6f6jC-6d43B:
undetectable
6f6jD-6d43B:
undetectable		 6f6jC-6d43B:
undetectable
6f6jD-6d43B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 6d43 TRIOSEPHOSPHATE
ISOMERASE
(Homo
sapiens) 		4 / 8 TRP B 191
ASP B 106
ILE B 150
ARG B  99
 None
 1.26A 6hisA-6d43B:
undetectable
6hisE-6d43B:
undetectable		 6hisA-6d43B:
19.32
6hisE-6d43B:
19.32