SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d46'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		5 / 12 ALA A 298
ILE A 266
ARG A 283
LEU A 341
LEU A 287
 None
 1.39A 1eiiA-6d46A:
undetectable		 1eiiA-6d46A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		5 / 12 ILE A 206
ILE A 138
VAL A 207
ILE A 217
ILE A 182
 None
 1.01A 1oipA-6d46A:
undetectable		 1oipA-6d46A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		5 / 12 ILE A 206
ILE A 138
VAL A 207
ILE A 217
ILE A 182
 None
 0.98A 1r5lA-6d46A:
undetectable		 1r5lA-6d46A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		3 / 3 PHE A 116
SER A  55
LEU A  45
 None
 0.75A 2w1bA-6d46A:
undetectable		 2w1bA-6d46A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		6 / 12 LEU A 236
ILE A 226
ILE A 203
PHE A 135
ILE A 241
VAL A  21
 None
 1.45A 2ygoA-6d46A:
undetectable		 2ygoA-6d46A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		5 / 9 LEU A 195
ILE A 219
LEU A 221
PHE A 167
THR A 142
 None
 1.11A 3fl9H-6d46A:
undetectable		 3fl9H-6d46A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		4 / 4 ILE A 217
PHE A 228
ILE A 219
THR A 234
 None
 1.14A 3ia4A-6d46A:
undetectable		 3ia4A-6d46A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		4 / 8 THR A   8
LEU A  87
LEU A  89
ILE A  99
 None
 0.85A 3nbqB-6d46A:
undetectable		 3nbqB-6d46A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		4 / 8 THR A   8
LEU A  87
LEU A  89
ILE A  99
 None
 0.80A 3nbqC-6d46A:
undetectable		 3nbqC-6d46A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		4 / 7 PHE A 353
TYR A 352
VAL A 362
ILE A 376
 None
 0.99A 4a97E-6d46A:
undetectable		 4a97E-6d46A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		4 / 8 PHE A 353
TYR A 352
VAL A 362
ILE A 376
 None
 0.96A 4a97C-6d46A:
undetectable		 4a97C-6d46A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		4 / 8 PHE A 353
TYR A 352
VAL A 362
ILE A 376
 None
 0.98A 4a97D-6d46A:
undetectable		 4a97D-6d46A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		4 / 8 PHE A 353
TYR A 352
VAL A 362
ILE A 376
 None
 0.98A 4a97G-6d46A:
undetectable		 4a97G-6d46A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		4 / 7 PHE A 353
TYR A 352
VAL A 362
ILE A 376
 None
 1.02A 4a97H-6d46A:
undetectable		 4a97H-6d46A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		4 / 8 PHE A 353
TYR A 352
VAL A 362
ILE A 376
 None
 1.01A 4a97I-6d46A:
undetectable		 4a97I-6d46A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		5 / 10 SER A 141
ILE A 146
ALA A 169
ALA A 170
ILE A 158
 None
 1.02A 4lbgA-6d46A:
undetectable		 4lbgA-6d46A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		6 / 9 THR A 172
GLY A 174
LEU A 177
PRO A 246
VAL A 375
MET A 377
 None
 0.65A 4mjrA-6d46A:
42.4		 4mjrA-6d46A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		5 / 12 LEU A 195
ALA A 200
THR A 234
ILE A 219
ILE A 217
 None
 1.05A 4o2bB-6d46A:
undetectable		 4o2bB-6d46A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		5 / 12 ALA A 275
VAL A 349
LEU A 337
LEU A 294
LEU A 287
 None
 1.04A 4qzuC-6d46A:
undetectable		 4qzuC-6d46A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		5 / 9 ILE A 182
LEU A 220
VAL A 193
LEU A 160
ILE A 226
 None
 1.34A 4r38C-6d46A:
undetectable		 4r38C-6d46A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		4 / 7 LEU A 155
THR A 172
PRO A 246
MET A 377
 None
 0.77A 5fxtA-6d46A:
38.8		 5fxtA-6d46A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		5 / 8 THR A 172
LEU A 177
PRO A 246
PRO A 361
MET A 377
 None
 0.45A 5g48A-6d46A:
38.6		 5g48A-6d46A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		6 / 9 LEU A 155
THR A 172
LEU A 177
PRO A 246
PRO A 361
MET A 377
 None
 0.63A 5g48B-6d46A:
38.7		 5g48B-6d46A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		5 / 12 LEU A 195
ALA A 200
THR A 234
ILE A 219
ILE A 217
 None
 1.03A 5mioB-6d46A:
undetectable		 5mioB-6d46A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		5 / 9 LEU A  45
VAL A  12
LEU A  15
ILE A  99
LEU A   4
 None
 1.36A 5og9A-6d46A:
undetectable		 5og9A-6d46A:
11.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 6d46 BETA SLIDING CLAMP
(Rickettsia
typhi) 		5 / 9 VAL A 340
LEU A 337
PHE A 332
VAL A 362
ILE A 364
 None
 1.13A 5om2A-6d46A:
undetectable
5om2B-6d46A:
undetectable		 5om2A-6d46A:
31.82
5om2B-6d46A:
22.39