SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d47'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		5 / 11 THR A  90
LEU A  86
VAL A  45
VAL A  69
VAL A  67
 None
 1.29A 1akdA-6d47A:
undetectable		 1akdA-6d47A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		4 / 8 PHE A 301
MET A 299
PHE A 335
LEU A 365
 None
 1.28A 1ea1A-6d47A:
undetectable		 1ea1A-6d47A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		5 / 10 THR A  90
LEU A  86
VAL A  45
VAL A  69
VAL A  67
 None
 1.30A 1o76A-6d47A:
undetectable		 1o76A-6d47A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		5 / 10 GLY A  58
VAL A  45
GLY A  44
ASN A  32
VAL A  29
 None
 1.11A 1pwyE-6d47A:
undetectable		 1pwyE-6d47A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		5 / 10 GLY A  58
VAL A  45
GLY A  44
ASN A  32
VAL A  29
 None
 1.23A 1v3qE-6d47A:
undetectable		 1v3qE-6d47A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		5 / 12 LEU A 265
LEU A 364
LEU A 347
PRO A 367
VAL A 352
 None
 1.38A 2qd4A-6d47A:
undetectable		 2qd4A-6d47A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		5 / 7 MET A 299
PHE A 301
ALA A 273
ALA A 275
LEU A 344
 None
 1.49A 2wx2A-6d47A:
undetectable		 2wx2A-6d47A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		4 / 5 THR A  35
SER A  43
SER A  82
ARG A  84
 None
 1.34A 3hlwB-6d47A:
undetectable		 3hlwB-6d47A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		4 / 8 MET A 299
PHE A 301
ALA A 275
LEU A 344
 None
 0.99A 3khmA-6d47A:
undetectable		 3khmA-6d47A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		4 / 6 ILE A 171
VAL A 169
LEU A 178
LEU A 191
 None
 0.79A 3kp6A-6d47A:
undetectable
3kp6B-6d47A:
undetectable		 3kp6A-6d47A:
21.74
3kp6B-6d47A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		4 / 8 MET A 299
PHE A 301
ALA A 275
LEU A 344
 None
 0.91A 3l4dD-6d47A:
undetectable		 3l4dD-6d47A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		3 / 3 CYH A 111
ASN A 113
LYS A  96
 None
 1.12A 4k50A-6d47A:
undetectable		 4k50A-6d47A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		5 / 12 ILE A 167
ALA A 152
ALA A 214
LEU A 240
ILE A 242
 None
 1.09A 4lnwA-6d47A:
undetectable		 4lnwA-6d47A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		5 / 12 ILE A 167
ALA A 152
ALA A 214
LEU A 240
ILE A 242
 None
 1.09A 4lnxA-6d47A:
undetectable		 4lnxA-6d47A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		5 / 12 LEU A 178
VAL A 169
GLY A 212
VAL A 204
LEU A 240
 None
 0.96A 4m2vA-6d47A:
undetectable		 4m2vA-6d47A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		5 / 12 VAL A 123
ALA A 122
TYR A 126
VAL A  41
THR A  78
 None
 1.30A 4mm4B-6d47A:
undetectable		 4mm4B-6d47A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		5 / 12 GLY A  83
GLY A  44
LEU A  46
ILE A  56
ALA A  30
 None
 0.99A 4qtuB-6d47A:
undetectable		 4qtuB-6d47A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		5 / 9 ALA A 180
THR A 181
ALA A 187
VAL A 206
ALA A 208
 None
 1.20A 4qvnK-6d47A:
undetectable
4qvnL-6d47A:
undetectable		 4qvnK-6d47A:
18.14
4qvnL-6d47A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		5 / 9 ALA A 180
THR A 181
ALA A 187
VAL A 206
ALA A 208
 None
 1.20A 4qvnY-6d47A:
undetectable
4qvnZ-6d47A:
undetectable		 4qvnY-6d47A:
18.14
4qvnZ-6d47A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		5 / 7 LEU A 164
THR A 181
PRO A 259
LEU A 394
MET A 396
 None
 0.79A 5fxtA-6d47A:
37.3		 5fxtA-6d47A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		5 / 8 LEU A 186
PRO A 259
PRO A 362
LEU A 394
MET A 396
 None
 0.64A 5g48A-6d47A:
36.9		 5g48A-6d47A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		5 / 8 THR A 181
LEU A 186
PRO A 259
LEU A 394
MET A 396
 None
 0.64A 5g48A-6d47A:
36.9		 5g48A-6d47A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		6 / 9 LEU A 164
THR A 181
PRO A 259
PRO A 362
LEU A 394
MET A 396
 None
 0.88A 5g48B-6d47A:
36.8		 5g48B-6d47A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		6 / 9 THR A 181
LEU A 186
PRO A 259
PRO A 362
LEU A 394
MET A 396
 None
 0.75A 5g48B-6d47A:
36.8		 5g48B-6d47A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		5 / 10 VAL A 188
ALA A 180
PHE A 261
VAL A 177
THR A 181
 None
 1.42A 6aogA-6d47A:
undetectable		 6aogA-6d47A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		5 / 10 VAL A 188
ALA A 180
PHE A 261
VAL A 177
THR A 181
 None
 1.43A 6aogB-6d47A:
undetectable		 6aogB-6d47A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		5 / 12 LEU A 306
ASP A 321
LEU A 308
PRO A 401
LEU A 400
 None
 1.17A 6b0lB-6d47A:
undetectable		 6b0lB-6d47A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 6d47 BETA SLIDING CLAMP
(Mycobacterium
marinum) 		5 / 9 LEU A 178
VAL A 176
SER A 227
LEU A 228
ILE A 171
 None
 1.15A 6fdyU-6d47A:
undetectable		 6fdyU-6d47A:
11.68