SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d4j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		5 / 11 THR A 807
PHE A 974
PHE A 919
LEU A 923
VAL A 927
 None
 1.30A 1q23L-6d4jA:
undetectable		 1q23L-6d4jA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		5 / 12 PHE A 573
ALA A 562
ILE A 565
GLU A 127
ALA A 498
 None
 1.49A 1vq1A-6d4jA:
2.3		 1vq1A-6d4jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		4 / 5 LEU A 777
PRO A 782
VAL A 781
ILE A 780
 None
 0.95A 2aoiB-6d4jA:
undetectable		 2aoiB-6d4jA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		5 / 12 LEU A 550
GLU A1095
GLY A1091
ASN A 555
ALA A 562
 None
 1.32A 2bm9B-6d4jA:
undetectable		 2bm9B-6d4jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		5 / 12 LEU A 550
GLU A1095
GLY A1091
ALA A 558
ALA A 562
 None
 1.17A 2bm9D-6d4jA:
undetectable		 2bm9D-6d4jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		4 / 8 TYR A1013
ASN A1011
VAL A 806
TYR A 804
 None
 1.15A 2fl5E-6d4jA:
undetectable
2fl5F-6d4jA:
undetectable		 2fl5E-6d4jA:
20.42
2fl5F-6d4jA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		3 / 3 ASN A 168
TYR A 797
SER A 356
 None
 0.66A 2gvcB-6d4jA:
undetectable		 2gvcB-6d4jA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		3 / 3 ASN A 168
TYR A 797
SER A 356
 None
 0.70A 2gvcE-6d4jA:
undetectable		 2gvcE-6d4jA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		4 / 4 ASP A 850
ASP A 930
ASP A 857
GLY A 290
 None
 1.16A 2igtC-6d4jA:
undetectable		 2igtC-6d4jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		4 / 5 PHE A 743
TYR A 740
LEU A1168
VAL A 753
 None
 1.21A 2m56A-6d4jA:
undetectable		 2m56A-6d4jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		4 / 4 VAL A 347
THR A 346
VAL A 343
GLY A 344
 None
 1.12A 2p2fB-6d4jA:
undetectable		 2p2fB-6d4jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		4 / 9 ILE A 805
ALA A 990
VAL A 994
CYH A 998
 None
 0.85A 2vufB-6d4jA:
undetectable		 2vufB-6d4jA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		4 / 5 VAL A 477
VAL A 510
ASP A 513
SER A1132
 None
 1.24A 2x45A-6d4jA:
undetectable		 2x45A-6d4jA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		4 / 5 VAL A 477
VAL A 510
ASP A 513
SER A1132
 None
 1.26A 2x45C-6d4jA:
undetectable		 2x45C-6d4jA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		3 / 3 TYR A1013
GLU A 126
THR A 143
 None
 1.02A 2y7hB-6d4jA:
undetectable		 2y7hB-6d4jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		3 / 3 TYR A1013
GLU A 126
THR A 368
 None
 0.87A 2y7hB-6d4jA:
undetectable		 2y7hB-6d4jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		5 / 11 VAL A1035
SER A1033
VAL A1084
ILE A 565
ALA A 578
 None
 1.01A 2zbzA-6d4jA:
undetectable		 2zbzA-6d4jA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		4 / 8 VAL A 481
VAL A 442
PHE A 505
VAL A 580
 None
 1.11A 3fhxB-6d4jA:
undetectable		 3fhxB-6d4jA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		4 / 5 THR A1133
GLU A1095
THR A 551
HIS A1099
 None
 1.20A 3glqA-6d4jA:
undetectable		 3glqA-6d4jA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		5 / 12 THR A 425
THR A 424
THR A 423
LEU A 366
TYR A1013
 None
 1.43A 3gwxB-6d4jA:
undetectable		 3gwxB-6d4jA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		5 / 12 ALA A 497
LEU A 570
PHE A 573
SER A 574
ILE A1085
 None
 1.04A 3hj3B-6d4jA:
undetectable		 3hj3B-6d4jA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		4 / 6 LEU A 431
SER A 433
PHE A 434
ILE A 780
 None
 0.97A 3ko0B-6d4jA:
undetectable		 3ko0B-6d4jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		4 / 6 LEU A 431
SER A 433
PHE A 434
ILE A 780
 None
 1.02A 3ko0S-6d4jA:
undetectable		 3ko0S-6d4jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		5 / 9 ALA A1080
ILE A 565
GLY A1023
ILE A1022
ILE A 567
 None
 1.06A 3nu4A-6d4jA:
undetectable		 3nu4A-6d4jA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		3 / 3 ALA A 412
VAL A 411
GLN A 177
 NAG  A1502 ( 4.8A)
None
None
 0.74A 3of4B-6d4jA:
1.9		 3of4B-6d4jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		5 / 12 SER A1089
ILE A1032
VAL A1035
LEU A1036
VAL A1057
 None
 0.99A 3w68A-6d4jA:
undetectable		 3w68A-6d4jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		5 / 12 GLN A 576
ALA A 577
ALA A 507
VAL A1137
LEU A1156
 None
 1.11A 4j6dA-6d4jA:
undetectable		 4j6dA-6d4jA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		6 / 12 VAL A1081
LEU A 775
VAL A1155
ILE A1085
ILE A1076
GLY A1075
 None
 1.12A 4y8wC-6d4jA:
2.9		 4y8wC-6d4jA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZD_A_RBFA201_1
(TRANSCRIPTIONAL
REGULATOR, PADR-LIKE
FAMILY)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		4 / 4 ALA A 990
VAL A 988
TRP A1018
ASP A 776
 None
 1.13A 4zzdA-6d4jA:
0.0		 4zzdA-6d4jA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		4 / 5 ALA A 736
TYR A 740
GLY A1091
LEU A1170
 None
 0.98A 5eslA-6d4jA:
undetectable		 5eslA-6d4jA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		4 / 8 LEU A1140
PHE A1152
PRO A 504
PHE A 573
 None
 1.02A 5m0oC-6d4jA:
undetectable		 5m0oC-6d4jA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		4 / 6 GLY A1163
LEU A1162
VAL A 510
PHE A 559
 None
 0.94A 6h7lA-6d4jA:
2.0		 6h7lA-6d4jA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		4 / 6 GLY A1163
LEU A1162
VAL A 510
PHE A 559
 None
 0.94A 6h7lB-6d4jA:
undetectable		 6h7lB-6d4jA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens) 		5 / 10 THR A1064
GLY A1091
GLY A1093
GLU A1095
PHE A 559
 None
 1.46A 6nqaK-6d4jA:
2.6		 6nqaK-6d4jA:
undetectable