SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d5i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		4 / 8 LEU A 384
PHE A 247
GLY A 248
TYR A 421
 None
 1.05A 1fapB-6d5iA:
undetectable		 1fapB-6d5iA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		4 / 5 PRO A 403
LEU A 513
THR A 441
ARG A 449
 None
None
ATP  A 601 ( 4.1A)
ATP  A 601 (-3.1A)
 1.31A 1i2wA-6d5iA:
undetectable		 1i2wA-6d5iA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		5 / 11 GLU A 511
ALA A 514
ASP A 519
PRO A 538
PHE A 478
 None
 1.14A 2admA-6d5iA:
undetectable		 2admA-6d5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		4 / 5 PHE A 478
PHE A 517
PHE A 405
VAL A 367
 None
 1.23A 2lh6A-6d5iA:
undetectable		 2lh6A-6d5iA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		5 / 11 GLY A 253
SER A 258
SER A 234
ALA A 354
ILE A 462
 ATP  A 601 (-2.9A)
None
None
None
None
 1.03A 2nnhA-6d5iA:
undetectable		 2nnhA-6d5iA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		5 / 12 ILE A  72
VAL A 135
MET A 219
PHE A  82
ARG A 198
 None
 1.24A 2qo4A-6d5iA:
undetectable		 2qo4A-6d5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		6 / 8 ARG A  65
LYS A 212
LYS A 213
HIS A 232
ASP A 269
ARG A 333
 PYR  A 602 (-4.0A)
PYR  A 602 (-4.5A)
MN  A 604 ( 2.1A)
MN  A 604 ( 3.3A)
MN  A 604 ( 2.5A)
ATP  A 601 ( 2.9A)
 0.91A 2rk8A-6d5iA:
29.3		 2rk8A-6d5iA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		4 / 8 LYS A 212
LYS A 213
ARG A 333
ALA A 250
 PYR  A 602 (-4.5A)
MN  A 604 ( 2.1A)
ATP  A 601 ( 2.9A)
ATP  A 601 (-3.3A)
 1.18A 2rk8A-6d5iA:
29.3		 2rk8A-6d5iA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		6 / 7 ARG A  65
LYS A 212
LYS A 213
HIS A 232
ASP A 269
ARG A 333
 PYR  A 602 (-4.0A)
PYR  A 602 (-4.5A)
MN  A 604 ( 2.1A)
MN  A 604 ( 3.3A)
MN  A 604 ( 2.5A)
ATP  A 601 ( 2.9A)
 0.84A 2rk8B-6d5iA:
29.4		 2rk8B-6d5iA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A600_1
(ORF12)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		5 / 11 THR A 404
ALA A 412
GLY A 410
PHE A 413
ARG A  65
 None
None
None
None
PYR  A 602 (-4.0A)
 1.09A 2xf3A-6d5iA:
undetectable		 2xf3A-6d5iA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B600_1
(ORF12)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		5 / 11 THR A 404
ALA A 412
GLY A 410
PHE A 413
ARG A  65
 None
None
None
None
PYR  A 602 (-4.0A)
 1.07A 2xf3B-6d5iA:
undetectable		 2xf3B-6d5iA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A600_1
(ORF12)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		5 / 10 THR A 404
ALA A 412
GLY A 410
PHE A 413
ARG A  65
 None
None
None
None
PYR  A 602 (-4.0A)
 1.14A 2xfsA-6d5iA:
undetectable		 2xfsA-6d5iA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B600_1
(ORF12)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		5 / 11 THR A 404
ALA A 412
GLY A 410
PHE A 413
ARG A  65
 None
None
None
None
PYR  A 602 (-4.0A)
 1.08A 2xfsB-6d5iA:
undetectable		 2xfsB-6d5iA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		5 / 11 THR A 404
ALA A 412
GLY A 410
PHE A 413
ARG A  65
 None
None
None
None
PYR  A 602 (-4.0A)
 1.09A 2xh9A-6d5iA:
undetectable		 2xh9A-6d5iA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		5 / 10 THR A 404
ALA A 412
GLY A 410
PHE A 413
ARG A  65
 None
None
None
None
PYR  A 602 (-4.0A)
 1.07A 2xh9B-6d5iA:
undetectable		 2xh9B-6d5iA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		5 / 12 PHE A 409
PHE A 517
LEU A 368
ASP A 363
THR A 252
 None
None
None
None
ATP  A 601 (-4.4A)
 0.95A 3gwuA-6d5iA:
undetectable		 3gwuA-6d5iA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		4 / 5 SER A 230
ARG A  65
GLY A 214
GLU A 210
 None
PYR  A 602 (-4.0A)
None
None
 1.26A 3k9fA-6d5iA:
undetectable
3k9fB-6d5iA:
undetectable
3k9fC-6d5iA:
undetectable		 3k9fA-6d5iA:
13.77
3k9fB-6d5iA:
13.77
3k9fC-6d5iA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		4 / 6 LEU A 438
SER A 372
TYR A 437
ALA A 481
 None
 0.94A 3rd0A-6d5iA:
undetectable		 3rd0A-6d5iA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		4 / 8 GLN A 430
VAL A 426
ASP A 377
GLN A 380
 None
 0.91A 3uy4A-6d5iA:
undetectable		 3uy4A-6d5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		5 / 12 LYS A 213
GLY A 248
GLY A 410
LEU A 257
ASP A 269
 MN  A 604 ( 2.1A)
None
None
ATP  A 601 ( 4.5A)
MN  A 604 ( 2.5A)
 1.20A 4blvB-6d5iA:
undetectable		 4blvB-6d5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		5 / 12 SER A 217
GLN A 144
PHE A  62
ILE A 202
ALA A 173
 None
 1.02A 4dx5B-6d5iA:
undetectable		 4dx5B-6d5iA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		4 / 5 GLY A 204
GLY A 203
ASN A 171
GLU A 188
 None
 1.05A 4fglC-6d5iA:
undetectable		 4fglC-6d5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		4 / 5 VAL A 141
ARG A 117
GLU A  35
LEU A  41
 None
 1.09A 4hojA-6d5iA:
undetectable		 4hojA-6d5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		5 / 12 ALA A 354
TRP A 273
PHE A 409
LEU A 360
THR A 355
 None
 1.43A 4kyaB-6d5iA:
undetectable		 4kyaB-6d5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		5 / 12 ALA A 354
TRP A 273
PHE A 409
LEU A 360
THR A 355
 None
 1.43A 4kyaD-6d5iA:
undetectable		 4kyaD-6d5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		5 / 12 ALA A 354
TRP A 273
PHE A 409
LEU A 360
THR A 355
 None
 1.42A 4kyaF-6d5iA:
undetectable		 4kyaF-6d5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		5 / 12 ALA A 354
TRP A 273
PHE A 409
LEU A 360
THR A 355
 None
 1.43A 4kyaH-6d5iA:
undetectable		 4kyaH-6d5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		4 / 7 PHE A 517
LEU A 368
ASP A 363
THR A 252
 None
None
None
ATP  A 601 (-4.4A)
 1.05A 4mmcA-6d5iA:
undetectable		 4mmcA-6d5iA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		4 / 5 PHE A 521
HIS A 382
LEU A 480
PRO A 369
 None
 1.30A 4o8zA-6d5iA:
undetectable		 4o8zA-6d5iA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_ACTA605_0
(SERUM ALBUMIN)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		3 / 3 LYS A 288
LYS A 390
ALA A 250
 ATP  A 601 (-4.8A)
None
ATP  A 601 (-3.3A)
 1.34A 4ot2A-6d5iA:
undetectable		 4ot2A-6d5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		4 / 6 ASP A 307
ARG A 154
ASN A 150
ASN A  26
 None
 1.30A 5l6eA-6d5iA:
undetectable		 5l6eA-6d5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		4 / 8 PRO A 483
ILE A 458
ALA A 461
ILE A 462
 None
 0.76A 5mvmA-6d5iA:
undetectable
5mvmB-6d5iA:
undetectable		 5mvmA-6d5iA:
18.29
5mvmB-6d5iA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		4 / 6 THR A  81
ASP A  80
ARG A  79
ASP A  76
 None
 1.18A 5tdzA-6d5iA:
undetectable		 5tdzA-6d5iA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		3 / 3 THR A 252
THR A 441
ARG A 449
 ATP  A 601 (-4.4A)
ATP  A 601 ( 4.1A)
ATP  A 601 (-3.1A)
 0.88A 5wm2A-6d5iA:
undetectable		 5wm2A-6d5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		3 / 3 TYR A  71
ASP A  93
ASP A  69
 None
 0.64A 5x6yA-6d5iA:
undetectable		 5x6yA-6d5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		5 / 10 LEU A 486
ILE A 459
PHE A 359
LEU A 374
GLU A 485
 None
 1.25A 5y7pG-6d5iA:
undetectable		 5y7pG-6d5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)
(Escherichia
coli) 		5 / 9 LEU A 467
SER A 466
ILE A 458
VAL A 439
ILE A 462
 None
 0.97A 6ef6A-6d5iA:
undetectable		 6ef6A-6d5iA:
undetectable