SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d6j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6d6j HIT FAMILY HYDROLASE
(Legionella
pneumophila) 		5 / 11 ILE A  63
ALA A  67
LEU A 102
ALA A  26
ILE A  49
 None
 1.11A 2aclE-6d6jA:
undetectable		 2aclE-6d6jA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 6d6j HIT FAMILY HYDROLASE
(Legionella
pneumophila) 		4 / 8 LEU A  64
ASN A  62
LEU A  59
ARG A  66
 None
CL  A 203 (-4.3A)
CL  A 203 (-4.1A)
CL  A 201 (-4.5A)
 1.19A 2xn3A-6d6jA:
undetectable
2xn3B-6d6jA:
undetectable		 2xn3A-6d6jA:
13.25
2xn3B-6d6jA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 6d6j HIT FAMILY HYDROLASE
(Legionella
pneumophila) 		5 / 12 LEU A  39
HIS A 101
ASP A  29
GLY A  92
PHE A   5
 None
 1.42A 3g1uA-6d6jA:
undetectable		 3g1uA-6d6jA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 6d6j HIT FAMILY HYDROLASE
(Legionella
pneumophila) 		5 / 12 LEU A  39
HIS A 101
GLN A  93
ASP A  29
GLY A  92
 None
 1.37A 3g1uB-6d6jA:
undetectable		 3g1uB-6d6jA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 6d6j HIT FAMILY HYDROLASE
(Legionella
pneumophila) 		5 / 12 LEU A  39
HIS A 101
ASP A  29
GLY A  92
PHE A   5
 None
 1.32A 3g1uD-6d6jA:
undetectable		 3g1uD-6d6jA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 6d6j HIT FAMILY HYDROLASE
(Legionella
pneumophila) 		5 / 12 LEU A  39
HIS A 101
ASP A  29
GLY A  92
PHE A   5
 None
 1.35A 3n58A-6d6jA:
undetectable		 3n58A-6d6jA:
11.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 6d6j HIT FAMILY HYDROLASE
(Legionella
pneumophila) 		7 / 10 PHE A   5
ILE A   8
ASP A  29
ILE A  30
LEU A  39
HIS A  99
HIS A 101
 None
 0.51A 3o1cA-6d6jA:
21.0		 3o1cA-6d6jA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 6d6j HIT FAMILY HYDROLASE
(Legionella
pneumophila) 		7 / 10 PHE A   5
ILE A   8
ASP A  29
ILE A  30
LEU A  39
HIS A  99
HIS A 101
 None
 0.52A 3o1xA-6d6jA:
21.0		 3o1xA-6d6jA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 6d6j HIT FAMILY HYDROLASE
(Legionella
pneumophila) 		7 / 10 PHE A   5
ILE A   8
ASP A  29
ILE A  30
LEU A  39
HIS A  99
HIS A 101
 None
 0.46A 3qgzA-6d6jA:
21.2		 3qgzA-6d6jA:
37.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 6d6j HIT FAMILY HYDROLASE
(Legionella
pneumophila) 		5 / 12 LEU A  39
HIS A 101
ASP A  29
GLY A  92
PHE A   5
 None
 1.35A 4pfjA-6d6jA:
undetectable		 4pfjA-6d6jA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 6d6j HIT FAMILY HYDROLASE
(Legionella
pneumophila) 		5 / 8 GLN A  33
ASN A  86
GLN A  93
HIS A  99
HIS A 101
 None
 0.41A 5km8A-6d6jA:
18.1
5km8B-6d6jA:
21.0		 5km8A-6d6jA:
27.87
5km8B-6d6jA:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 6d6j HIT FAMILY HYDROLASE
(Legionella
pneumophila) 		5 / 12 ILE A   8
PHE A   5
ILE A  41
LEU A  25
ASP A  29
 None
 0.97A 5km9B-6d6jA:
21.1		 5km9B-6d6jA:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 6d6j HIT FAMILY HYDROLASE
(Legionella
pneumophila) 		7 / 12 PHE A   5
ILE A   8
ASP A  29
LEU A  39
VAL A  95
HIS A  99
HIS A 101
 None
 0.45A 5km9B-6d6jA:
21.1		 5km9B-6d6jA:
27.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 6d6j HIT FAMILY HYDROLASE
(Legionella
pneumophila) 		8 / 12 PHE A   5
ILE A   8
ASP A  29
ILE A  30
LEU A  39
VAL A  95
HIS A  99
HIS A 101
 None
 0.57A 5uvmB-6d6jA:
20.1		 5uvmB-6d6jA:
33.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 6d6j HIT FAMILY HYDROLASE
(Legionella
pneumophila) 		5 / 12 LEU A  39
HIS A 101
ASP A  29
GLY A  92
PHE A   5
 None
 1.37A 6aphA-6d6jA:
undetectable		 6aphA-6d6jA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_1
(-)		 6d6j HIT FAMILY HYDROLASE
(Legionella
pneumophila) 		5 / 12 LEU A  39
HIS A 101
ASP A  29
GLY A  92
PHE A   5
 None
 1.36A 6gbnA-6d6jA:
undetectable		 6gbnA-6d6jA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)		 6d6j HIT FAMILY HYDROLASE
(Legionella
pneumophila) 		5 / 12 LEU A  39
HIS A 101
ASP A  29
GLY A  92
PHE A   5
 None
 1.36A 6gbnB-6d6jA:
undetectable		 6gbnB-6d6jA:
11.06