SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d6q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		3 / 3 ALA K 253
VAL K 263
TRP K 264
 None
 0.92A 1c4dA-6d6qK:
undetectable
1c4dB-6d6qK:
undetectable		 1c4dA-6d6qK:
undetectable
1c4dB-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		5 / 12 THR K 738
SER K 633
ILE K 742
ARG K 746
LEU K 853
 None
None
None
A  O  57 ( 3.4A)
None
 0.91A 1ddrA-6d6qK:
undetectable		 1ddrA-6d6qK:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		4 / 8 SER M 882
ILE M 880
LEU M1003
GLU M1002
 C  O  22 ( 3.5A)
None
None
C  O  22 ( 3.0A)
 0.81A 1eupA-6d6qM:
undetectable		 1eupA-6d6qM:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		5 / 12 ILE K 701
CYH K 747
HIS K 691
TYR K 765
LEU K 632
 None
None
A  O  58 ( 4.1A)
None
A  O  58 ( 4.4A)
 1.36A 1fm6X-6d6qK:
undetectable		 1fm6X-6d6qK:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		4 / 8 ILE M 320
PHE M 343
PHE M 338
LEU M 551
 None
 0.84A 1fslB-6d6qM:
undetectable		 1fslB-6d6qM:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		3 / 4 LYS K 807
ALA K 811
MET K 758
 None
 1.07A 1hk3A-6d6qK:
undetectable		 1hk3A-6d6qK:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGL_L_ESTL911_1
(IG GAMMA-1-CHAIN
IG KAPPA-CHAIN)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		5 / 10 ALA K 783
TYR K 753
LEU K 817
TYR K 782
HIS K 774
 None
None
None
None
A  O  60 ( 3.3A)
 1.41A 1jglH-6d6qK:
undetectable
1jglL-6d6qK:
undetectable		 1jglH-6d6qK:
17.51
1jglL-6d6qK:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		5 / 12 PHE M 979
ILE M 993
THR M 466
LEU M 431
ILE M1034
 None
 1.30A 1kqwA-6d6qM:
undetectable		 1kqwA-6d6qM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 6d6q EXOSOME COMPLEX
COMPONENT RRP42
EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 6 ILE K 227
GLU E 181
LEU E 171
ASP E 173
 None
 1.02A 1mt1B-6d6qK:
undetectable
1mt1C-6d6qK:
undetectable		 1mt1B-6d6qK:
16.95
1mt1C-6d6qK:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		4 / 5 GLU M 990
LEU M 438
ASP M 435
LEU M 431
 None
 1.15A 1n13B-6d6qM:
undetectable
1n13C-6d6qM:
undetectable		 1n13B-6d6qM:
20.75
1n13C-6d6qM:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		5 / 12 LEU M 232
MET M 235
ARG M 244
ILE M 186
TYR M 279
 None
A  O  23 ( 4.5A)
None
None
None
 1.36A 1ot7B-6d6qM:
undetectable		 1ot7B-6d6qM:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		5 / 12 ARG M 502
ILE M 320
LEU M 537
ASP M 540
ALA M 323
 A  N   1 ( 4.8A)
None
None
A  N   1 ( 3.7A)
None
 1.08A 1r9oA-6d6qM:
undetectable		 1r9oA-6d6qM:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 6d6q EXOSOME COMPLEX
COMPONENT RRP4
(Homo
sapiens) 		5 / 11 HIS H 266
GLU H 283
SER H 243
ILE H 276
GLU H 279
 None
 0.89A 1rnrA-6d6qH:
undetectable		 1rnrA-6d6qH:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 6d6q EXOSOME COMPLEX
COMPONENT RRP4
(Homo
sapiens) 		3 / 3 PRO H 190
ASP H 188
ASP H 253
 None
 0.78A 1sqfA-6d6qH:
undetectable		 1sqfA-6d6qH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		4 / 7 VAL M 496
TYR M 402
CYH M 399
ARG M 258
 None
 1.04A 1t46A-6d6qM:
undetectable		 1t46A-6d6qM:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 6d6q EXOSOME COMPLEX
COMPONENT RRP40
(Homo
sapiens) 		4 / 7 GLN G 264
ALA G 256
ARG G 271
ASN G 252
 None
 1.12A 1t9wA-6d6qG:
undetectable		 1t9wA-6d6qG:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 5 ASN K 419
THR K 392
GLN K 389
PHE K 416
 None
 1.31A 1xmuB-6d6qK:
undetectable		 1xmuB-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		3 / 3 THR K 262
GLU K 289
HIS K 266
 None
 0.90A 1xwfA-6d6qK:
undetectable		 1xwfA-6d6qK:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		3 / 3 THR K 262
GLU K 289
HIS K 266
 None
 0.91A 1xwfC-6d6qK:
2.3		 1xwfC-6d6qK:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		3 / 3 THR K 262
GLU K 289
HIS K 266
 None
 0.89A 1xwfD-6d6qK:
undetectable		 1xwfD-6d6qK:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		5 / 12 LEU K 610
LEU K 613
ASN K 614
LEU K 616
ALA K 617
 None
 0.90A 1ya3C-6d6qK:
undetectable		 1ya3C-6d6qK:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6d6q EXOSOME COMPLEX
COMPONENT RRP42
(Homo
sapiens) 		5 / 12 LEU E 192
GLY E  47
ASN E 162
ALA E 159
ALA E 155
 None
 1.02A 2bm9C-6d6qE:
undetectable		 2bm9C-6d6qE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6d6q EXOSOME COMPLEX
COMPONENT RRP42
(Homo
sapiens) 		5 / 12 LEU E 192
GLY E  47
ASN E 162
ALA E 159
ALA E 155
 None
 0.87A 2bm9E-6d6qE:
undetectable		 2bm9E-6d6qE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6d6q EXOSOME COMPLEX
COMPONENT RRP42
(Homo
sapiens) 		5 / 12 LEU E 192
GLY E  47
ASN E 162
ALA E 159
ALA E 155
 None
 0.94A 2bm9F-6d6qE:
undetectable		 2bm9F-6d6qE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		5 / 11 ALA K 744
LEU K 725
ALA K 728
SER K 633
LEU K 632
 None
None
None
None
A  O  58 ( 4.4A)
 1.05A 2bxeB-6d6qK:
undetectable		 2bxeB-6d6qK:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 5 LEU K 616
LEU K 620
LEU K 668
MET K 566
 None
 0.93A 2oaxF-6d6qK:
undetectable		 2oaxF-6d6qK:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		3 / 3 ASN K 499
LEU K 500
HIS K 568
 None
 0.67A 2q6fB-6d6qK:
undetectable		 2q6fB-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 5 THR K 262
ARG K 252
ALA K 253
ARG K 379
 None
 1.35A 2qhfA-6d6qK:
undetectable		 2qhfA-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 6d6q EXOSOME COMPLEX
COMPONENT RRP4
EXOSOME COMPLEX
COMPONENT RRP42
(Homo
sapiens) 		5 / 10 ASP E 213
ARG E  27
LEU E 216
THR E 215
ILE H 280
 None
 1.33A 2v0mA-6d6qE:
undetectable		 2v0mA-6d6qE:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 6d6q EXOSOME COMPLEX
COMPONENT RRP42
EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		3 / 3 ARG E 284
GLY E 281
SER K   4
 None
 0.66A 2xctB-6d6qE:
undetectable		 2xctB-6d6qE:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 7 GLY K 612
ILE K 597
THR K 659
LEU K 613
 None
 0.89A 2xrhA-6d6qK:
undetectable		 2xrhA-6d6qK:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 6d6q EXOSOME COMPLEX
COMPONENT RRP4
EXOSOME RNA HELICASE
MTR4
(Homo
sapiens;
Homo
sapiens) 		3 / 3 TYR H 163
GLU M 577
ASN M 580
 None
 1.00A 2y7hC-6d6qH:
undetectable		 2y7hC-6d6qH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 7 ASP K 520
ARG K 789
ILE K 813
TYR K 801
 None
 0.93A 2yfbA-6d6qK:
undetectable		 2yfbA-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 6 ASP K 520
ARG K 789
ILE K 813
TYR K 801
 None
 1.01A 2yfbB-6d6qK:
undetectable		 2yfbB-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 6d6q EXOSOME COMPLEX
COMPONENT RRP40
(Homo
sapiens) 		5 / 12 PHE G 129
ASP G 161
VAL G 157
LEU G 141
PHE G 146
 None
 1.14A 2zzmA-6d6qG:
undetectable		 2zzmA-6d6qG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		4 / 7 ILE M 467
ILE M 994
LEU M 448
LEU M 431
 None
 0.92A 3adxA-6d6qM:
undetectable		 3adxA-6d6qM:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 6d6q EXOSOME COMPLEX
COMPONENT RRP40
(Homo
sapiens) 		5 / 10 PHE G 129
ASP G 161
VAL G 157
LEU G 141
PHE G 146
 None
 1.25A 3ay0A-6d6qG:
undetectable		 3ay0A-6d6qG:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		3 / 3 CYH M 911
PHE M 962
PHE M 912
 None
 1.04A 3cr5X-6d6qM:
undetectable		 3cr5X-6d6qM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		4 / 4 GLU M1001
GLY M1026
THR M1028
GLU M1025
 None
 0.97A 3e9xA-6d6qM:
undetectable		 3e9xA-6d6qM:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		5 / 12 THR K 131
LEU K  73
VAL K  98
ILE K 109
THR K 113
 None
 1.37A 3frqA-6d6qK:
undetectable		 3frqA-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		3 / 3 ASN M 219
ASP M 208
ARG M 244
 None
 0.87A 3k13C-6d6qM:
undetectable		 3k13C-6d6qM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		5 / 11 ILE K  89
PHE K 123
GLU K 126
THR K  93
ILE K 149
 None
 0.96A 3kw4A-6d6qK:
undetectable		 3kw4A-6d6qK:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 6d6q EXOSOME COMPLEX
COMPONENT RRP4
(Homo
sapiens) 		5 / 12 LEU H 108
VAL H 107
SER H 155
SER H 111
GLN H  92
 None
 1.25A 3m7rA-6d6qH:
undetectable		 3m7rA-6d6qH:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 6d6q EXOSOME COMPLEX
COMPONENT RRP4
(Homo
sapiens) 		3 / 3 GLY H 133
TRP H  96
VAL H  91
 None
 0.76A 3n62B-6d6qH:
undetectable		 3n62B-6d6qH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 6d6q EXOSOME COMPLEX
COMPONENT RRP4
(Homo
sapiens) 		3 / 3 GLY H 133
TRP H  96
VAL H  91
 None
 0.75A 3n65B-6d6qH:
undetectable		 3n65B-6d6qH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 6d6q EXOSOME COMPLEX
COMPONENT RRP4
(Homo
sapiens) 		3 / 3 GLY H 133
TRP H  96
VAL H  91
 None
 0.74A 3n66B-6d6qH:
undetectable		 3n66B-6d6qH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		3 / 3 ILE K 513
VAL K 785
ARG K 789
 None
 0.76A 3p73A-6d6qK:
undetectable		 3p73A-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		5 / 12 TYR K  65
GLY K  32
ALA K  47
ASN K  87
HIS K  64
 None
 1.49A 3s8pA-6d6qK:
undetectable		 3s8pA-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 6d6q EXOSOME COMPLEX
COMPONENT RRP40
(Homo
sapiens) 		4 / 5 LEU G  86
LEU G  71
GLY G  68
GLY G  70
 None
 0.84A 3si7C-6d6qG:
undetectable
3si7D-6d6qG:
undetectable		 3si7C-6d6qG:
undetectable
3si7D-6d6qG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		3 / 3 LEU K 160
HIS K 159
MET K 163
 None
ZN  K2002 (-2.9A)
None
 0.76A 3thrD-6d6qK:
undetectable		 3thrD-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		4 / 5 GLU M 261
ASP M 884
ASN M 568
GLU M 885
 None
 1.28A 3vywD-6d6qM:
2.4		 3vywD-6d6qM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 6d6q EXOSOME COMPLEX
COMPONENT RRP4
(Homo
sapiens) 		5 / 12 ILE H 205
ILE H 241
VAL H 245
LEU H 244
VAL H 281
 None
 1.25A 3w68C-6d6qH:
2.7		 3w68C-6d6qH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 6d6q EXOSOME COMPLEX
COMPONENT RRP40
(Homo
sapiens) 		4 / 7 VAL G 239
PHE G 200
VAL G 202
ILE G 218
 None
 0.94A 3zjqA-6d6qG:
undetectable		 3zjqA-6d6qG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 6d6q EXOSOME COMPLEX
COMPONENT RRP40
(Homo
sapiens) 		4 / 7 VAL G 239
PHE G 200
VAL G 202
ILE G 218
 None
 0.93A 3zjqB-6d6qG:
undetectable		 3zjqB-6d6qG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 6 ILE K 582
VAL K 504
ILE K 563
CYH K 562
 None
 0.92A 4asdA-6d6qK:
undetectable		 4asdA-6d6qK:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 6d6q EXOSOME COMPLEX
COMPONENT RRP42
(Homo
sapiens) 		5 / 12 GLU E 278
ASN E 162
PHE E 161
ASP E  40
GLY E 281
 None
 1.47A 4djeA-6d6qE:
undetectable		 4djeA-6d6qE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6d6q EXOSOME COMPLEX
COMPONENT RRP42
(Homo
sapiens) 		5 / 11 PHE E 149
SER E 153
LEU E 109
VAL E 139
THR E  56
 None
 0.97A 4eilA-6d6qE:
undetectable		 4eilA-6d6qE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6d6q EXOSOME COMPLEX
COMPONENT RRP42
(Homo
sapiens) 		5 / 11 VAL E 139
ALA E 106
SER E 153
LEU E 160
VAL E 137
 None
 1.34A 4eilA-6d6qE:
undetectable		 4eilA-6d6qE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6d6q EXOSOME COMPLEX
COMPONENT RRP42
(Homo
sapiens) 		5 / 11 PHE E 149
SER E 153
LEU E 109
VAL E 139
THR E  56
 None
 0.99A 4eilC-6d6qE:
undetectable		 4eilC-6d6qE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6d6q EXOSOME COMPLEX
COMPONENT RRP42
(Homo
sapiens) 		5 / 11 VAL E 139
ALA E 106
SER E 153
LEU E 160
VAL E 137
 None
 1.30A 4eilC-6d6qE:
undetectable		 4eilC-6d6qE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6d6q EXOSOME COMPLEX
COMPONENT RRP42
(Homo
sapiens) 		5 / 11 PHE E 149
SER E 153
LEU E 109
VAL E 139
THR E  56
 None
 0.98A 4eilE-6d6qE:
undetectable		 4eilE-6d6qE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6d6q EXOSOME COMPLEX
COMPONENT RRP42
(Homo
sapiens) 		5 / 11 VAL E 139
ALA E 106
SER E 153
LEU E 160
VAL E 137
 None
 1.32A 4eilE-6d6qE:
undetectable		 4eilE-6d6qE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6d6q EXOSOME COMPLEX
COMPONENT RRP40
(Homo
sapiens) 		4 / 8 ASN G 234
GLY G 232
VAL G 117
ILE G 193
 None
 0.89A 4fglD-6d6qG:
undetectable		 4fglD-6d6qG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		4 / 8 GLY M 263
VAL M 264
ILE M 270
PHE M 281
 None
 0.70A 4fglD-6d6qM:
undetectable		 4fglD-6d6qM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		5 / 12 LEU K 610
LEU K 613
ASN K 614
LEU K 616
ALA K 617
 None
 0.84A 4fn9A-6d6qK:
undetectable		 4fn9A-6d6qK:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		5 / 12 LEU K 610
LEU K 613
ASN K 614
ALA K 617
MET K 667
 None
None
None
None
A  O  61 ( 4.6A)
 1.01A 4fn9B-6d6qK:
undetectable		 4fn9B-6d6qK:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		5 / 12 LEU K 610
LEU K 613
ASN K 614
LEU K 616
ALA K 617
 None
 0.80A 4fn9B-6d6qK:
undetectable		 4fn9B-6d6qK:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 6d6q EXOSOME COMPLEX
COMPONENT RRP4
(Homo
sapiens) 		5 / 12 ILE H 141
GLY H 218
GLY H 164
MET H 113
ILE H 220
 None
 1.13A 4iv0B-6d6qH:
undetectable		 4iv0B-6d6qH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 8 LEU K 548
CYH K 549
PHE K 512
PRO K 541
 None
 1.13A 4j7uD-6d6qK:
undetectable		 4j7uD-6d6qK:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ4_B_IMNB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		5 / 10 TYR K 772
HIS K 774
VAL K 787
ILE K 786
LEU K 817
 A  O  60 ( 4.7A)
A  O  60 ( 3.3A)
None
None
None
 1.45A 4jq4B-6d6qK:
undetectable		 4jq4B-6d6qK:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		5 / 10 VAL K 873
VAL K 862
ILE K 852
LEU K 885
LEU K 894
 None
 1.43A 4jtqA-6d6qK:
undetectable		 4jtqA-6d6qK:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 6d6q EXOSOME COMPLEX
COMPONENT RRP42
EXOSOME COMPLEX
COMPONENT RRP4
(Homo
sapiens;
Homo
sapiens) 		4 / 4 ILE H 242
SER H 243
ASP E  25
ASP E  31
 None
 1.18A 4krhB-6d6qH:
undetectable		 4krhB-6d6qH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6d6q EXOSOME COMPLEX
COMPONENT RRP42
(Homo
sapiens) 		5 / 11 VAL E 139
ALA E 106
SER E 153
LEU E 160
VAL E 137
 None
 1.34A 4kyaA-6d6qE:
undetectable		 4kyaA-6d6qE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6d6q EXOSOME COMPLEX
COMPONENT RRP42
(Homo
sapiens) 		5 / 10 VAL E 139
ALA E 106
SER E 153
LEU E 160
VAL E 137
 None
 1.32A 4kyaC-6d6qE:
undetectable		 4kyaC-6d6qE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6d6q EXOSOME COMPLEX
COMPONENT RRP42
(Homo
sapiens) 		5 / 12 VAL E 139
ALA E 106
SER E 153
LEU E 160
VAL E 137
 None
 1.21A 4kyaD-6d6qE:
undetectable		 4kyaD-6d6qE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6d6q EXOSOME COMPLEX
COMPONENT RRP42
(Homo
sapiens) 		5 / 11 VAL E 139
ALA E 106
SER E 153
LEU E 160
VAL E 137
 None
 1.33A 4kyaE-6d6qE:
undetectable		 4kyaE-6d6qE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6d6q EXOSOME COMPLEX
COMPONENT RRP42
(Homo
sapiens) 		5 / 12 VAL E 139
ALA E 106
SER E 153
LEU E 160
VAL E 137
 None
 1.23A 4kyaF-6d6qE:
undetectable		 4kyaF-6d6qE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6d6q EXOSOME COMPLEX
COMPONENT RRP42
(Homo
sapiens) 		5 / 11 VAL E 139
ALA E 106
SER E 153
LEU E 160
VAL E 137
 None
 1.31A 4kyaG-6d6qE:
undetectable		 4kyaG-6d6qE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6d6q EXOSOME COMPLEX
COMPONENT RRP42
(Homo
sapiens) 		5 / 12 VAL E 139
ALA E 106
SER E 153
LEU E 160
VAL E 137
 None
 1.19A 4kyaH-6d6qE:
undetectable		 4kyaH-6d6qE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		5 / 12 LEU K 610
LEU K 613
ASN K 614
LEU K 616
ALA K 617
 None
 0.91A 4ltwA-6d6qK:
undetectable		 4ltwA-6d6qK:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 6d6q EXOSOME COMPLEX
COMPONENT RRP4
(Homo
sapiens) 		5 / 12 ILE H 141
GLY H 218
GLY H 164
MET H 113
ILE H 220
 None
 1.13A 4mwzA-6d6qH:
undetectable		 4mwzA-6d6qH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		5 / 12 LEU K 551
ALA K 507
LEU K 558
VAL K 555
ILE K 459
 None
 1.05A 4x1yB-6d6qK:
undetectable		 4x1yB-6d6qK:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		5 / 12 LEU K 551
ALA K 507
LEU K 558
VAL K 555
ILE K 459
 None
 1.04A 4x20B-6d6qK:
undetectable		 4x20B-6d6qK:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 6 PRO K 375
ILE K 402
VAL K 417
ARG K 384
 A  O  51 ( 4.5A)
None
None
A  O  48 ( 3.6A)
 1.13A 4xe5A-6d6qK:
undetectable		 4xe5A-6d6qK:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		4 / 4 GLY M 533
VAL M 535
PHE M 485
ILE M 390
 None
 1.07A 4xv2B-6d6qM:
undetectable		 4xv2B-6d6qM:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		4 / 7 SER M 588
TYR M 590
SER M 561
GLU M 267
 None
 1.25A 4xzkA-6d6qM:
undetectable		 4xzkA-6d6qM:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		5 / 12 VAL M 441
LEU M1040
ILE M 462
LEU M 463
ILE M1034
 None
 1.07A 4y0rA-6d6qM:
undetectable		 4y0rA-6d6qM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_C_PACC601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		5 / 12 PHE M 281
PHE M 251
ILE M 296
HIS M 300
VAL M 277
 None
 1.35A 4yfbC-6d6qM:
undetectable		 4yfbC-6d6qM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_F_PACF601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		5 / 12 PHE M 281
PHE M 251
ILE M 296
HIS M 300
VAL M 277
 None
 1.33A 4yfbF-6d6qM:
undetectable		 4yfbF-6d6qM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		5 / 12 PHE M 281
PHE M 251
ILE M 296
HIS M 300
VAL M 277
 None
 1.34A 4yfbI-6d6qM:
undetectable		 4yfbI-6d6qM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		5 / 12 PHE M 281
PHE M 251
ILE M 296
HIS M 300
VAL M 277
 None
 1.34A 4yfbL-6d6qM:
0.8		 4yfbL-6d6qM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 5 SER K 831
ALA K 830
HIS K 835
LEU K 532
 None
 1.31A 5dzkc-6d6qK:
undetectable
5dzkq-6d6qK:
undetectable		 5dzkc-6d6qK:
undetectable
5dzkq-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 6d6q EXOSOME COMPLEX
COMPONENT RRP42
(Homo
sapiens) 		3 / 3 CYH E 204
LYS E 205
HIS E 210
 None
 1.02A 5js5A-6d6qE:
undetectable		 5js5A-6d6qE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		3 / 3 CYH M 911
LYS M 963
HIS M 965
 None
 0.95A 5js5A-6d6qM:
undetectable		 5js5A-6d6qM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 8 TYR K 156
THR K 124
CYH K  39
TRP K 155
 None
None
ZN  K2002 (-2.3A)
None
 1.39A 5kxiA-6d6qK:
undetectable
5kxiB-6d6qK:
undetectable		 5kxiA-6d6qK:
11.17
5kxiB-6d6qK:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 8 TYR K 156
THR K 124
CYH K  39
TRP K 155
 None
None
ZN  K2002 (-2.3A)
None
 1.44A 5kxiD-6d6qK:
undetectable
5kxiE-6d6qK:
undetectable		 5kxiD-6d6qK:
11.17
5kxiE-6d6qK:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 5 HIS K 788
ILE K 506
SER K 510
ALA K 559
 None
 1.22A 5msdA-6d6qK:
2.2		 5msdA-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 6d6q EXOSOME COMPLEX
COMPONENT RRP40
(Homo
sapiens) 		5 / 9 ILE G 237
ILE G 229
ILE G 253
ALA G 251
LEU G 250
 None
 1.14A 5mvmA-6d6qG:
undetectable
5mvmE-6d6qG:
undetectable		 5mvmA-6d6qG:
24.44
5mvmE-6d6qG:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		3 / 3 ALA M 974
GLN M 904
THR M 906
 None
 0.47A 5n0oA-6d6qM:
1.3		 5n0oA-6d6qM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		5 / 12 VAL K 903
LEU K 702
ALA K 705
SER K 708
LEU K 736
 None
 1.22A 5nd7B-6d6qK:
undetectable		 5nd7B-6d6qK:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 8 LEU K 632
ALA K 751
MET K 748
TYR K 765
 A  O  58 ( 4.4A)
A  O  59 ( 3.1A)
None
None
 0.97A 5nu7A-6d6qK:
undetectable		 5nu7A-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 7 VAL K 862
ILE K 864
VAL K 907
ALA K 850
 None
 0.75A 5osrA-6d6qK:
undetectable		 5osrA-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		5 / 12 ILE M 186
LEU M 211
SER M 195
LEU M 236
THR M 269
 None
 1.05A 5tiwB-6d6qM:
undetectable		 5tiwB-6d6qM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		3 / 3 GLU M 294
HIS M 298
VAL M  99
 None
 0.69A 5trqB-6d6qM:
undetectable		 5trqB-6d6qM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 5 ASP K 488
ASN K 487
ASP K 784
ASN K 671
 A  O  61 ( 3.3A)
A  O  62 ( 3.2A)
None
None
 1.21A 5vooA-6d6qK:
undetectable		 5vooA-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 5 ASP K 488
ASN K 487
ASP K 784
ARG K 624
 A  O  61 ( 3.3A)
A  O  62 ( 3.2A)
None
None
 1.23A 5vooB-6d6qK:
undetectable		 5vooB-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 5 ASP K 488
ASN K 487
ASP K 784
ASN K 671
 A  O  61 ( 3.3A)
A  O  62 ( 3.2A)
None
None
 1.22A 5vooB-6d6qK:
undetectable		 5vooB-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 5 ASP K 488
ASN K 487
ASP K 784
ASN K 671
 A  O  61 ( 3.3A)
A  O  62 ( 3.2A)
None
None
 1.26A 5vooC-6d6qK:
undetectable		 5vooC-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 5 ASP K 488
ASN K 487
ASP K 784
ARG K 624
 A  O  61 ( 3.3A)
A  O  62 ( 3.2A)
None
None
 1.25A 5vooD-6d6qK:
undetectable		 5vooD-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 5 ASP K 488
ASN K 487
ASP K 784
ASN K 671
 A  O  61 ( 3.3A)
A  O  62 ( 3.2A)
None
None
 1.25A 5vooD-6d6qK:
undetectable		 5vooD-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 5 ASP K 488
ASN K 487
ASP K 784
ASN K 671
 A  O  61 ( 3.3A)
A  O  62 ( 3.2A)
None
None
 1.28A 5vooE-6d6qK:
undetectable		 5vooE-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 4 ASP K 488
ASN K 487
ASP K 784
ASN K 671
 A  O  61 ( 3.3A)
A  O  62 ( 3.2A)
None
None
 1.23A 5vooF-6d6qK:
undetectable		 5vooF-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6d6q EXOSOME COMPLEX
COMPONENT RRP4
(Homo
sapiens) 		3 / 3 GLY H 133
TRP H  96
VAL H  91
 None
 0.73A 5vuoB-6d6qH:
undetectable		 5vuoB-6d6qH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 6 HIS K 774
VAL K 752
LEU K 817
GLN K 750
 A  O  60 ( 3.3A)
None
None
A  O  57 ( 4.9A)
 1.37A 5xdhA-6d6qK:
undetectable
5xdhC-6d6qK:
undetectable		 5xdhA-6d6qK:
22.45
5xdhC-6d6qK:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		4 / 6 GLN K 750
HIS K 774
VAL K 752
LEU K 817
 A  O  57 ( 4.9A)
A  O  60 ( 3.3A)
None
None
 1.33A 5xdhA-6d6qK:
undetectable
5xdhC-6d6qK:
undetectable		 5xdhA-6d6qK:
22.45
5xdhC-6d6qK:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		4 / 8 ILE M 942
ASN M 568
ALA M 877
LEU M 571
 None
 0.80A 5y7pC-6d6qM:
undetectable		 5y7pC-6d6qM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens) 		4 / 8 ILE M 942
ASN M 568
ALA M 877
LEU M 571
 None
 0.83A 5y7pE-6d6qM:
undetectable		 5y7pE-6d6qM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 6d6q EXOSOME COMPLEX
COMPONENT RRP40
(Homo
sapiens) 		3 / 3 VAL G 230
TYR G 164
GLU G 228
 None
 0.95A 5zmqD-6d6qG:
undetectable
5zmqE-6d6qG:
undetectable		 5zmqD-6d6qG:
undetectable
5zmqE-6d6qG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens) 		5 / 12 LEU K 160
VAL K  72
GLY K  30
CYH K  39
LEU K  48
 None
None
None
ZN  K2002 (-2.3A)
None
 1.04A 6a7pA-6d6qK:
undetectable		 6a7pA-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC609_0
(ALPHA-AMYLASE)		 6d6q EXOSOME COMPLEX
COMPONENT RRP40
(Homo
sapiens) 		4 / 7 GLY G 232
TRP G 238
MET G 190
TYR G 164
 None
 1.45A 6ag0C-6d6qG:
undetectable		 6ag0C-6d6qG:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 6d6q EXOSOME COMPLEX
COMPONENT RRP4
(Homo
sapiens) 		4 / 8 GLN H 173
VAL H 174
ILE H 242
THR H 246
 None
 0.82A 6cduG-6d6qH:
undetectable
6cduH-6d6qH:
undetectable		 6cduG-6d6qH:
undetectable
6cduH-6d6qH:
undetectable