SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d6t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 6d6t HUMAN GABA-A
RECEPTOR SUBUNIT
GAMMA-2
(Homo
sapiens) 		5 / 12 ILE E  62
LEU E 206
PHE E 227
ILE E  74
THR E 193
 None
 1.12A 1rb2B-6d6tE:
undetectable		 1rb2B-6d6tE:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 6d6t HUMAN GABA-A
RECEPTOR SUBUNIT
GAMMA-2
(Homo
sapiens) 		3 / 3 PHE E 203
VAL E 190
TRP E 196
 None
 0.89A 2cc8A-6d6tE:
1.5		 2cc8A-6d6tE:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 6d6t HUMAN GABA-A
RECEPTOR SUBUNIT
GAMMA-2
(Homo
sapiens) 		3 / 3 PHE E 203
VAL E 190
TRP E 196
 None
 0.88A 2ccbA-6d6tE:
1.5		 2ccbA-6d6tE:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 6d6t HUMAN GABA-A
RECEPTOR SUBUNIT
GAMMA-2
(Homo
sapiens) 		3 / 3 PHE E 203
VAL E 190
TRP E 196
 None
 0.89A 2vx9A-6d6tE:
1.4		 2vx9A-6d6tE:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 6d6t HUMAN GABA-A
RECEPTOR SUBUNIT
GAMMA-2
(Homo
sapiens) 		3 / 3 ASP E 161
PHE E 201
SER E 164
 None
 0.94A 3i5uB-6d6tE:
undetectable		 3i5uB-6d6tE:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6d6t HUMAN GABA-A
RECEPTOR SUBUNIT
GAMMA-2
(Homo
sapiens) 		5 / 12 ILE E  62
LEU E 206
PHE E 227
ILE E  74
THR E 193
 None
 1.09A 4ptjA-6d6tE:
undetectable		 4ptjA-6d6tE:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 6d6t HUMAN GABA-A
RECEPTOR SUBUNIT
GAMMA-2
(Homo
sapiens) 		4 / 6 TYR E 220
VAL E 221
ILE E 179
GLU E 178
 None
 1.07A 5z3jA-6d6tE:
undetectable		 5z3jA-6d6tE:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D6T_D_FYPD406_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
HUMAN GABA-A
RECEPTOR SUBUNIT
GAMMA-2)		 6d6t HUMAN GABA-A
RECEPTOR SUBUNIT
GAMMA-2
(Homo
sapiens) 		5 / 11 ASP E  56
TYR E  58
PHE E  77
ALA E  79
THR E 142
 None
 0.00A 6d6tD-6d6tE:
28.1
6d6tE-6d6tE:
36.5		 6d6tD-6d6tE:
undetectable
6d6tE-6d6tE:
undetectable