SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d6v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 6 PHE A 323
PHE A 318
GLU A 238
GLY A 240
 None
None
A  B  16 ( 3.6A)
None
 1.16A 1icuC-6d6vA:
2.6
1icuD-6d6vA:
3.0		 1icuC-6d6vA:
14.16
1icuD-6d6vA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 6 PHE A 323
PHE A 318
GLU A 238
GLY A 240
 None
None
A  B  16 ( 3.6A)
None
 1.16A 1kqbA-6d6vA:
2.2
1kqbB-6d6vA:
2.2		 1kqbA-6d6vA:
undetectable
1kqbB-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 6 PHE A 323
PHE A 318
GLU A 238
GLY A 240
 None
None
A  B  16 ( 3.6A)
None
 1.11A 1kqbC-6d6vA:
2.2
1kqbD-6d6vA:
undetectable		 1kqbC-6d6vA:
undetectable
1kqbD-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 6 PHE A 318
GLU A 238
GLY A 240
PHE A 323
 None
A  B  16 ( 3.6A)
None
None
 1.16A 1kqbC-6d6vA:
2.2
1kqbD-6d6vA:
undetectable		 1kqbC-6d6vA:
undetectable
1kqbD-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 6d6v TELOMERASE
HOLOENZYME TEB
HETEROTRIMER TEB3
SUBUNIT
(Tetrahymena
thermophila) 		4 / 5 ARG F  60
LEU F  78
ASP F  57
LEU F  41
 None
 1.19A 1n13B-6d6vF:
undetectable
1n13C-6d6vF:
undetectable		 1n13B-6d6vF:
20.00
1n13C-6d6vF:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
TELOMERASE-ASSOCIATE
D PROTEIN 82
(Tetrahymena
thermophila) 		5 / 11 PHE D 590
THR A 114
GLY A 111
ILE A 115
VAL A 119
 None
 1.19A 1phgA-6d6vD:
undetectable		 1phgA-6d6vD:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 7 THR A  61
TYR A  37
ASN A 138
LEU A  40
 None
 1.00A 1qzrB-6d6vA:
undetectable		 1qzrB-6d6vA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 6d6v TELOMERASE
HOLOENZYME TEB2
SUBUNIT
TELOMERASE
HOLOENZYME TEB
HETEROTRIMER TEB3
SUBUNIT
(Tetrahymena
thermophila;
Tetrahymena
thermophila) 		4 / 7 ASP E  91
ASN E  35
PHE F 118
ARG F  74
 None
 1.49A 1rqpB-6d6vE:
undetectable		 1rqpB-6d6vE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 6 PHE A 136
ASN A 135
ASN A 125
GLN A 716
 None
 1.34A 1t9uA-6d6vA:
2.8		 1t9uA-6d6vA:
5.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 7 ILE A 495
ILE A 383
ILE A 467
PHE A 476
 None
 0.88A 1uwjA-6d6vA:
undetectable		 1uwjA-6d6vA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 6d6v TELOMERASE-ASSOCIATE
D PROTEIN 82
(Tetrahymena
thermophila) 		4 / 4 LEU D 642
LEU D 610
SER D 607
LEU D 587
 None
 1.13A 1ya3A-6d6vD:
undetectable		 1ya3A-6d6vD:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 6d6v TELOMERASE
ASSOCIATED PROTEIN
P65
(Tetrahymena
thermophila) 		4 / 8 LYS H 382
ILE H 499
GLU H 506
ILE H 502
 None
 0.84A 2j9dJ-6d6vH:
4.0
2j9dK-6d6vH:
2.7
2j9dL-6d6vH:
3.5		 2j9dJ-6d6vH:
undetectable
2j9dK-6d6vH:
undetectable
2j9dL-6d6vH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 6d6v TELOMERASE
HOLOENZYME TEB2
SUBUNIT
TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		3 / 3 ASP A 147
TYR A 150
LYS E 104
 None
 0.97A 2othA-6d6vA:
undetectable		 2othA-6d6vA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 6d6v TELOMERASE
ASSOCIATED PROTEIN
P65
(Tetrahymena
thermophila) 		3 / 3 ASN H 481
LEU H 480
HIS H 482
 None
 0.80A 2q6fB-6d6vH:
undetectable		 2q6fB-6d6vH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 6 ILE A 488
ARG A 473
ILE A 469
PHE A 408
 None
C  B  43 ( 4.0A)
None
None
 0.83A 2q72A-6d6vA:
undetectable		 2q72A-6d6vA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB926_0
(FERROCHELATASE)		 6d6v TELOMERASE-ASSOCIATE
D PROTEIN 82
(Tetrahymena
thermophila) 		5 / 10 LEU D 646
ILE D 544
SER D 617
VAL D 627
GLY D 624
 None
 1.34A 2qd4B-6d6vD:
undetectable		 2qd4B-6d6vD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 6d6v TELOMERASE
HOLOENZYME TEB2
SUBUNIT
(Tetrahymena
thermophila) 		4 / 8 MET E  38
LEU E  34
ARG E 166
GLY E  62
 None
 1.07A 2qd5B-6d6vE:
undetectable		 2qd5B-6d6vE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 6 TYR A 477
PRO A 537
ILE A 545
LEU A 533
 None
None
C  B  46 ( 3.9A)
None
 1.31A 2wekB-6d6vA:
undetectable		 2wekB-6d6vA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 6d6v TELOMERASE-ASSOCIATE
D PROTEIN 82
TELOMERASE
HOLOENZYME TEB2
SUBUNIT
(Tetrahymena
thermophila;
Tetrahymena
thermophila) 		5 / 11 GLN D 522
GLU D 519
THR D 595
PHE E 177
GLY E 173
 None
 1.31A 3ag1A-6d6vD:
undetectable
3ag1B-6d6vD:
undetectable
3ag1T-6d6vD:
undetectable		 3ag1A-6d6vD:
undetectable
3ag1B-6d6vD:
undetectable
3ag1T-6d6vD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		5 / 12 ASN A 125
ILE A 110
LEU A 100
VAL A 157
LEU A 131
 None
 0.86A 3dzuA-6d6vA:
undetectable		 3dzuA-6d6vA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		3 / 3 ASN A 217
ASP A 451
GLN A 440
 U  B 135 ( 3.0A)
None
None
 0.50A 3eeyC-6d6vA:
undetectable		 3eeyC-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		3 / 3 ASN A 217
ASP A 451
GLN A 440
 U  B 135 ( 3.0A)
None
None
 0.49A 3eeyD-6d6vA:
undetectable		 3eeyD-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		3 / 3 ASN A 217
ASP A 451
GLN A 440
 U  B 135 ( 3.0A)
None
None
 0.51A 3eeyE-6d6vA:
undetectable		 3eeyE-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 6d6v TELOMERASE
HOLOENZYME TEB2
SUBUNIT
(Tetrahymena
thermophila) 		5 / 11 VAL E  99
ILE E 100
ILE E  85
SER E  78
PRO E  83
 None
 1.10A 3kpcA-6d6vE:
undetectable		 3kpcA-6d6vE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 6d6v TELOMERASE
HOLOENZYME TEB2
SUBUNIT
(Tetrahymena
thermophila) 		5 / 12 VAL E  99
ILE E 100
ILE E  85
SER E  78
PRO E  83
 None
 1.11A 3kpdB-6d6vE:
undetectable		 3kpdB-6d6vE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_B_URFB521_1
(RNA DEPENDENT RNA
POLYMERASE)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 4 ARG A 543
ASP A 618
ASP A 815
ASP A 816
 None
 1.10A 3naiB-6d6vA:
8.1		 3naiB-6d6vA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		3 / 3 PHE A1060
LYS A1067
SER A1068
 C  B  62 ( 3.7A)
None
None
 1.02A 3tyeB-6d6vA:
undetectable		 3tyeB-6d6vA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6d6v TELOMERASE
HOLOENZYME TEB
HETEROTRIMER TEB3
SUBUNIT
(Tetrahymena
thermophila) 		3 / 3 PHE F  45
CYH F  33
HIS F  53
 None
 1.26A 3u9fF-6d6vF:
undetectable		 3u9fF-6d6vF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6d6v TELOMERASE
HOLOENZYME TEB
HETEROTRIMER TEB3
SUBUNIT
(Tetrahymena
thermophila) 		3 / 3 PHE F  45
CYH F  33
HIS F  53
 None
 1.14A 3u9fL-6d6vF:
undetectable		 3u9fL-6d6vF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 6d6v TELOMERASE
ASSOCIATED PROTEIN
P65
(Tetrahymena
thermophila) 		5 / 12 LYS H 486
LEU H 487
THR H 501
ILE H 383
ILE H 381
 None
 1.18A 3ut5B-6d6vH:
undetectable		 3ut5B-6d6vH:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		5 / 12 VAL A 409
PHE A 401
ILE A 314
ILE A 467
VAL A 471
 None
 1.07A 3w67B-6d6vA:
undetectable		 3w67B-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		5 / 12 VAL A 409
PHE A 401
ILE A 314
ILE A 467
VAL A 471
 None
 1.02A 3w68C-6d6vA:
undetectable		 3w68C-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6d6v TELOMERASE-ASSOCIATE
D PROTEIN 82
(Tetrahymena
thermophila) 		4 / 7 GLU D 632
ILE D 631
HIS D 584
VAL D 562
 None
 1.07A 4a97A-6d6vD:
undetectable		 4a97A-6d6vD:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6d6v TELOMERASE-ASSOCIATE
D PROTEIN 82
(Tetrahymena
thermophila) 		4 / 7 GLU D 632
ILE D 631
HIS D 584
VAL D 562
 None
 1.11A 4a97H-6d6vD:
undetectable		 4a97H-6d6vD:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6d6v TELOMERASE-ASSOCIATE
D PROTEIN 82
(Tetrahymena
thermophila) 		4 / 6 GLU D 632
ILE D 631
HIS D 584
VAL D 562
 None
 1.07A 4a97I-6d6vD:
undetectable		 4a97I-6d6vD:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		3 / 3 TYR A 477
ARG A 473
HIS A 234
 None
C  B  43 ( 4.0A)
C  B  39 ( 3.5A)
 1.21A 4fubA-6d6vA:
undetectable		 4fubA-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 6d6v TELOMERASE
HOLOENZYME TEB2
SUBUNIT
TELOMERASE-ASSOCIATE
D PROTEIN 82
(Tetrahymena
thermophila) 		4 / 6 GLU E 155
THR E  70
THR E  31
ASN D 540
 None
 1.34A 4pfjB-6d6vE:
undetectable		 4pfjB-6d6vE:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_D_HQED503_1
(CATALASE)		 6d6v TELOMERASE
HOLOENZYME TEB2
SUBUNIT
TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		5 / 9 ILE E 100
ASP E 107
PRO E 110
GLN E 143
ASP A  95
 None
 1.35A 4qopD-6d6vE:
undetectable		 4qopD-6d6vE:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 5 TYR A 373
GLN A 487
SER A 486
ASP A 421
 None
 1.26A 4qtuB-6d6vA:
undetectable		 4qtuB-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		5 / 12 LEU A 131
THR A 112
ILE A 110
ALA A 170
ILE A  97
 None
 1.12A 4rp8C-6d6vA:
undetectable		 4rp8C-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		3 / 3 GLU A1086
ALA A1087
PHE A1090
 None
 0.34A 4v1fA-6d6vA:
undetectable		 4v1fA-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		3 / 3 GLU A1086
ALA A1087
PHE A1090
 None
 0.38A 4v1fC-6d6vA:
undetectable		 4v1fC-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 7 ASN A 937
PRO A 934
PHE A1009
PHE A1090
 None
 1.32A 4v32A-6d6vA:
undetectable		 4v32A-6d6vA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_B_QI9B602_0
(CYTOCHROME P450 2D6)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		5 / 9 PHE A  59
LEU A  60
SER A 134
THR A 130
VAL A 169
 None
 1.49A 4wnvB-6d6vA:
0.6		 4wnvB-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		5 / 12 PHE A 151
PHE A 148
LEU A 139
LEU A  36
LEU A  40
 None
 1.28A 4xumA-6d6vA:
undetectable		 4xumA-6d6vA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 6d6v TELOMERASE
HOLOENZYME TEB
HETEROTRIMER TEB3
SUBUNIT
TELOMERASE
HOLOENZYME TEB2
SUBUNIT
(Tetrahymena
thermophila) 		4 / 6 ASP E  91
THR E  93
TYR F  10
THR F  27
 None
 1.43A 5b6iB-6d6vE:
undetectable		 5b6iB-6d6vE:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 6d6v TELOMERASE
HOLOENZYME TEB
HETEROTRIMER TEB3
SUBUNIT
(Tetrahymena
thermophila) 		3 / 3 ASP F  57
ASN F  79
GLN F  80
 None
 0.45A 5k7uA-6d6vF:
undetectable		 5k7uA-6d6vF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		5 / 10 ILE A 641
ILE A 740
ILE A 744
ILE A 745
ILE A 564
 None
 0.92A 5murE-6d6vA:
4.2		 5murE-6d6vA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		5 / 12 LEU A 392
GLY A 394
LYS A 395
LYS A 396
LEU A 402
 None
 1.34A 5nwvA-6d6vA:
undetectable		 5nwvA-6d6vA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		5 / 10 ILE A1091
ILE A1088
LEU A1085
ILE A1020
ASN A1016
 None
 1.23A 5vkqA-6d6vA:
5.0
5vkqD-6d6vA:
5.0		 5vkqA-6d6vA:
undetectable
5vkqD-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		5 / 10 ILE A1020
ASN A1016
ILE A1091
ILE A1088
LEU A1085
 None
 1.19A 5vkqA-6d6vA:
5.0
5vkqB-6d6vA:
5.0		 5vkqA-6d6vA:
undetectable
5vkqB-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		5 / 10 ILE A1020
ASN A1016
ILE A1091
ILE A1088
LEU A1085
 None
 1.21A 5vkqC-6d6vA:
5.0
5vkqD-6d6vA:
5.0		 5vkqC-6d6vA:
undetectable
5vkqD-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 6d6v TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		5 / 12 VAL A 615
THR A 616
ILE A 850
PHE A 866
PHE A 845
 None
 1.20A 6hlpA-6d6vA:
undetectable		 6hlpA-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6d6v TELOMERASE-ASSOCIATE
D PROTEIN 82
(Tetrahymena
thermophila) 		4 / 5 LEU D 541
GLN D 592
PHE D 590
PHE D 643
 None
 1.39A 6nmpP-6d6vD:
undetectable
6nmpW-6d6vD:
undetectable		 6nmpP-6d6vD:
undetectable
6nmpW-6d6vD:
undetectable