SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d6y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JOL_B_FFOB361_0 (DIHYDROFOLATE REDUCTASE)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	5 / 12	PHE A 672 ILE A 696 ARG A 775 PRO A 771 THR A 726	None	1.01A	1jolB-6d6yA: 2.1	1jolB-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MX1_A_THAA1_1 (LIVER CARBOXYLESTERASE I)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	5 / 11	LEU A 636 GLY A 813 VAL A 843 LEU A 847 LEU A 994	None	1.08A	1mx1A-6d6yA: undetectable	1mx1A-6d6yA: 8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NV8_A_SAMA300_0 (HEMK PROTEIN)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	5 / 12	ILE A 836 GLY A 837 GLY A 839 THR A 863 ASN A 910	None SAH A1102 (-3.5A) SAH A1102 (-3.4A) None SAH A1102 (-4.0A)	1.08A	1nv8A-6d6yA: 12.0	1nv8A-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QAO_A_SAMA245_0 (ERMC' METHYLTRANSFERASE)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	7 / 12	GLU A 835 GLY A 837 GLY A 839 ILE A 865 ASP A 889 ILE A 890 ASN A 910	None SAH A1102 (-3.5A) SAH A1102 (-3.4A) SAH A1102 (-3.6A) SAH A1102 (-3.5A) SAH A1102 (-4.4A) SAH A1102 (-4.0A)	0.94A	1qaoA-6d6yA: 10.3	1qaoA-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RB3_A_MTXA161_1 (DIHYDROFOLATE REDUCTASE)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	5 / 10	ALA A 512 ASP A 516 LEU A 555 ILE A 509 THR A 513	None	1.25A	1rb3A-6d6yA: undetectable	1rb3A-6d6yA: 17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SG9_A_SAMA301_0 (HEMK PROTEIN)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	5 / 12	ILE A 836 GLY A 839 THR A 863 SER A 866 ASN A 910	None SAH A1102 (-3.4A) None None SAH A1102 (-4.0A)	1.25A	1sg9A-6d6yA: 12.1	1sg9A-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F6D_A_ACRA996_1 (GLUCOAMYLASE GLU1)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	4 / 7	ASN A 807 ASP A 804 THR A 840 GLY A 841	None None SAH A1102 (-4.1A) None	0.96A	2f6dA-6d6yA: undetectable	2f6dA-6d6yA: 11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HC4_A_VDXA525_2 (VITAMIN D RECEPTOR)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	4 / 7	LEU A 711 LEU A 708 ARG A 702 TYR A 950	None	1.23A	2hc4A-6d6yA: undetectable	2hc4A-6d6yA: 17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7H_C_SAMC530_1 (TYPE I RESTRICTION ENZYME ECOKI M PROTEIN)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	3 / 3	TYR A 748 GLU A 659 ASN A 652	None	0.95A	2y7hC-6d6yA: 2.9	2y7hC-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3H5G_B_LEIB16_0 (COIL SER L16D-PEN)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	4 / 5	LEU A 708 GLN A 686 LEU A 690 GLU A 687	None	1.02A	3h5gA-6d6yA: undetectable 3h5gB-6d6yA: undetectable	3h5gA-6d6yA: undetectable 3h5gB-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JW3_A_TOPA208_1 (DIHYDROFOLATE REDUCTASE)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	5 / 10	ALA A 545 LEU A 570 LEU A 611 ILE A 559 THR A 542	None	1.08A	3jw3A-6d6yA: undetectable	3jw3A-6d6yA: 18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QL3_A_FOLA161_0 (DIHYDROFOLATE REDUCTASE)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	5 / 12	ALA A 512 ASP A 516 LEU A 555 ILE A 509 THR A 513	None	1.19A	3ql3A-6d6yA: undetectable	3ql3A-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SGL_A_SAMA692_0 (TRNA 5-METHYLAMINOMETHYL- 2-THIOURIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN MNMC)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	5 / 12	GLU A 835 GLY A 837 GLY A 839 THR A 840 ASP A 889	None SAH A1102 (-3.5A) SAH A1102 (-3.4A) SAH A1102 (-4.1A) SAH A1102 (-3.5A)	0.65A	3sglA-6d6yA: 6.5	3sglA-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UFN_A_ROCA402_1 (HIV-1 PROTEASE)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	4 / 5	ARG A 967 LEU A 978 VAL A 982 ASP A 963	None	1.13A	3ufnA-6d6yA: undetectable 3ufnB-6d6yA: undetectable	3ufnA-6d6yA: 19.61 3ufnB-6d6yA: 19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UNA_A_SALA1340_1 (XANTHINE DEHYDROGENASE/OXIDAS E)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	5 / 9	LEU A 923 SER A 926 PHE A 988 LEU A 938 ALA A1013	None	1.22A	3unaA-6d6yA: undetectable	3unaA-6d6yA: 4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UNA_B_SALB1340_1 (XANTHINE DEHYDROGENASE/OXIDAS E)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	5 / 9	LEU A 923 SER A 926 PHE A 988 LEU A 938 ALA A1013	None	1.21A	3unaB-6d6yA: 2.0	3unaB-6d6yA: 4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V4T_C_ACTC502_0 (UDP-N-ACETYLGLUCOSAM INE 1-CARBOXYVINYLTRANSF ERASE)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	3 / 3	PRO A 964 ASP A 963 GLU A 962	None	0.70A	3v4tC-6d6yA: 1.9	3v4tC-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B17_A_SAMA1358_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE M)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	5 / 12	GLY A 837 GLY A 841 GLY A 842 ASP A 864 ASP A 889	SAH A1102 (-3.5A) None SAH A1102 ( 4.9A) SAH A1102 (-2.4A) SAH A1102 (-3.5A)	0.65A	4b17A-6d6yA: 9.5	4b17A-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BBO_B_ACTB1114_0 (BLR5658 PROTEIN)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	3 / 3	TRP A 626 TRP A 584 THR A 579	None	1.11A	4bboB-6d6yA: undetectable	4bboB-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4D7H_A_H4BA902_1 (NITRIC OXIDE SYNTHASE OXYGENASE)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	3 / 3	ARG A 967 THR A 942 TRP A 979	None	1.22A	4d7hA-6d6yA: undetectable	4d7hA-6d6yA: 14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E1G_B_LNLB701_2 (PROSTAGLANDIN G/H SYNTHASE 2)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	4 / 7	TYR A 950 VAL A 763 LEU A 767 VAL A 742	None	0.88A	4e1gB-6d6yA: 2.1	4e1gB-6d6yA: 9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EJJ_B_NCTB501_1 (CYTOCHROME P450 2A6)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	4 / 7	PHE A 793 VAL A 762 GLY A 952 PHE A 797	None	0.79A	4ejjB-6d6yA: undetectable	4ejjB-6d6yA: 11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FGZ_B_CQAB301_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	4 / 8	GLY A 845 GLU A 835 LEU A 810 VAL A 814	None	0.89A	4fgzB-6d6yA: 15.3	4fgzB-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IV0_B_SAMB302_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE, PUTATIVE)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	5 / 12	GLY A 837 GLY A 839 ILE A 865 ASP A 889 ILE A 890	SAH A1102 (-3.5A) SAH A1102 (-3.4A) SAH A1102 (-3.6A) SAH A1102 (-3.5A) SAH A1102 (-4.4A)	0.94A	4iv0B-6d6yA: 15.2	4iv0B-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IV8_A_SAMA301_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE, PUTATIVE)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	6 / 12	GLY A 837 GLY A 839 ASP A 864 ILE A 865 ASP A 889 ILE A 890	SAH A1102 (-3.5A) SAH A1102 (-3.4A) SAH A1102 (-2.4A) SAH A1102 (-3.6A) SAH A1102 (-3.5A) SAH A1102 (-4.4A)	0.94A	4iv8A-6d6yA: 15.4	4iv8A-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IV8_B_SAMB301_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE, PUTATIVE)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	6 / 12	GLY A 837 GLY A 839 ASP A 864 ILE A 865 ASP A 889 ILE A 890	SAH A1102 (-3.5A) SAH A1102 (-3.4A) SAH A1102 (-2.4A) SAH A1102 (-3.6A) SAH A1102 (-3.5A) SAH A1102 (-4.4A)	0.96A	4iv8B-6d6yA: 15.3	4iv8B-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KT0_A_PQNA2001_1 (PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1 PHOTOSYSTEM I REACTION CENTER SUBUNIT IX)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	5 / 11	PHE A 797 GLY A 842 GLY A 795 ILE A 773 LEU A 774	None SAH A1102 ( 4.9A) None None None	1.06A	4kt0A-6d6yA: 2.2 4kt0J-6d6yA: undetectable	4kt0A-6d6yA: 7.88 4kt0J-6d6yA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LTW_A_486A303_1 (ANCESTRAL STEROID RECEPTOR 2)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	5 / 9	LEU A 711 ALA A 665 LEU A 735 TYR A 770 LEU A 707	None	1.38A	4ltwA-6d6yA: undetectable	4ltwA-6d6yA: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M11_D_MXMD606_1 (PROSTAGLANDIN G/H SYNTHASE 2)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	5 / 12	MET A 675 ILE A 696 LEU A 694 VAL A 724 LEU A 707	None	1.39A	4m11D-6d6yA: undetectable	4m11D-6d6yA: 9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4P65_A_IPHA101_0 (INSULIN)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	5 / 10	LEU A 555 HIS A 546 ALA A 558 LEU A 539 LEU A 576	None	1.22A	4p65A-6d6yA: undetectable 4p65B-6d6yA: undetectable 4p65F-6d6yA: undetectable 4p65H-6d6yA: undetectable	4p65A-6d6yA: undetectable 4p65B-6d6yA: undetectable 4p65F-6d6yA: undetectable 4p65H-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QDJ_A_SAMA301_0 (MAGNESIUM-PROTOPORPH YRIN O-METHYLTRANSFERASE)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	5 / 12	GLY A 837 GLY A 839 ILE A 865 SER A 866 VAL A 912	SAH A1102 (-3.5A) SAH A1102 (-3.4A) SAH A1102 (-3.6A) None SAH A1102 ( 4.5A)	0.66A	4qdjA-6d6yA: 14.9	4qdjA-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	5 / 12	ALA A 545 LEU A 570 ILE A 559 THR A 561 GLY A 599	None	0.93A	4rzvA-6d6yA: undetectable	4rzvA-6d6yA: 12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UGL_A_H4BA902_1 (NITRIC OXIDE SYNTHASE)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	3 / 3	ARG A 967 THR A 942 TRP A 979	None	1.23A	4uglA-6d6yA: undetectable	4uglA-6d6yA: 14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BW4_A_SAMA301_0 (16S RRNA (ADENINE(1408)-N(1)) -METHYLTRANSFERASE)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	5 / 12	GLY A 837 GLY A 839 THR A 844 ASP A 864 ILE A 890	SAH A1102 (-3.5A) SAH A1102 (-3.4A) None SAH A1102 (-2.4A) SAH A1102 (-4.4A)	1.14A	5bw4A-6d6yA: 12.4	5bw4A-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DPD_A_SAMA601_0 (PROTEIN LYSINE METHYLTRANSFERASE 1)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	5 / 12	GLU A 835 GLY A 837 SER A 866 ILE A 890 VAL A 912	None SAH A1102 (-3.5A) None SAH A1102 (-4.4A) SAH A1102 ( 4.5A)	0.68A	5dpdA-6d6yA: 14.0	5dpdA-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DPD_B_SAMB601_0 (PROTEIN LYSINE METHYLTRANSFERASE 1)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	5 / 12	GLY A 837 ASP A 864 SER A 866 ILE A 890 VAL A 912	SAH A1102 (-3.5A) SAH A1102 (-2.4A) None SAH A1102 (-4.4A) SAH A1102 ( 4.5A)	0.80A	5dpdB-6d6yA: 14.1	5dpdB-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5G6C_A_H4BA902_1 (NITRIC OXIDE SYNTHASE OXYGENASE)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	3 / 3	ARG A 967 THR A 942 TRP A 979	None	1.23A	5g6cA-6d6yA: undetectable	5g6cA-6d6yA: 14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HG0_A_SAMA301_0 (PANTOTHENATE SYNTHETASE)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	5 / 12	GLY A 957 LEU A 960 VAL A 982 GLN A 956 LEU A 955	None	1.22A	5hg0A-6d6yA: undetectable	5hg0A-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KB5_A_ADNA401_2 (ADENOSINE KINASE)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	4 / 4	ASN A 931 LEU A 930 SER A 903 LEU A 834	None	1.37A	5kb5A-6d6yA: 4.0	5kb5A-6d6yA: 13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BP4_A_SAMA505_1 (HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-9 SPECIFIC)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	3 / 3	ILE A1011 ASN A 911 CYH A 972	None	0.92A	6bp4A-6d6yA: undetectable	6bp4A-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CK2_C_IPHC101_0 (INSULIN A CHAIN INSULIN B CHAIN)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	4 / 4	ILE A 517 LEU A 555 HIS A 546 ALA A 558	None	0.80A	6ck2C-6d6yA: undetectable 6ck2D-6d6yA: undetectable	6ck2C-6d6yA: undetectable 6ck2D-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6ECT_A_SAMA1300_1 (STIE PROTEIN)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	4 / 5	THR A 786 ARG A 765 THR A 840 ASP A 864	None None SAH A1102 (-4.1A) SAH A1102 (-2.4A)	1.40A	6ectA-6d6yA: 14.3	6ectA-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6ECX_A_SAMA1301_1 (STIE PROTEIN)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	4 / 5	THR A 786 ARG A 765 THR A 840 ASP A 864	None None SAH A1102 (-4.1A) SAH A1102 (-2.4A)	1.35A	6ecxA-6d6yA: 14.1	6ecxA-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HUO_D_08HD501_0 (GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOB UTYRIC ACID RECEPTOR SUBUNIT ALPHA-1 GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	4 / 8	ASN A 781 PHE A 785 VAL A 868 TYR A 872	None	1.18A	6huoC-6d6yA: 3.3 6huoD-6d6yA: undetectable	6huoC-6d6yA: 23.16 6huoD-6d6yA: 19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6IFT_A_SAMA301_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE A)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	5 / 12	GLU A 835 ILE A 836 GLY A 837 GLY A 839 ILE A 865	None None SAH A1102 (-3.5A) SAH A1102 (-3.4A) SAH A1102 (-3.6A)	0.52A	6iftA-6d6yA: 9.3	6iftA-6d6yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6J20_A_GBQA1201_1 (SUBSTANCE-P RECEPTOR,ENDOLYSIN)	6d6y	APRA METHYLTRANSFERASE 2 (Moorea bouillonii)	4 / 7	ILE A 831 TRP A 882 HIS A 854 VAL A 818	None	1.07A	6j20A-6d6yA: undetectable	6j20A-6d6yA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1JOL_B_FFOB361_0","DIHYDROFOLATE REDUCTASE","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",5,"PHE A 672;ILE A 696;ARG A 775;PRO A 771;THR A 726","None","1.01A","1jolB-6d6yA:2.1","1jolB-6d6yA:undetectable"],["1MX1_A_THAA1_1","LIVER CARBOXYLESTERASE I","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",5,"LEU A 636;GLY A 813;VAL A 843;LEU A 847;LEU A 994","None","1.08A","1mx1A-6d6yA:undetectable","1mx1A-6d6yA:8.50"],["1NV8_A_SAMA300_0","HEMK PROTEIN","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",5,"ILE A 836;GLY A 837;GLY A 839;THR A 863;ASN A 910","None;SAH A1102 (-3.5A);SAH A1102 (-3.4A);None;SAH A1102 (-4.0A)","1.08A","1nv8A-6d6yA:12.0","1nv8A-6d6yA:undetectable"],["1QAO_A_SAMA245_0","ERMC' METHYLTRANSFERASE","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",7,"GLU A 835;GLY A 837;GLY A 839;ILE A 865;ASP A 889;ILE A 890;ASN A 910","None;SAH A1102 (-3.5A);SAH A1102 (-3.4A);SAH A1102 (-3.6A);SAH A1102 (-3.5A);SAH A1102 (-4.4A);SAH A1102 (-4.0A)","0.94A","1qaoA-6d6yA:10.3","1qaoA-6d6yA:undetectable"],["1RB3_A_MTXA161_1","DIHYDROFOLATE REDUCTASE","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",5,"ALA A 512;ASP A 516;LEU A 555;ILE A 509;THR A 513","None","1.25A","1rb3A-6d6yA:undetectable","1rb3A-6d6yA:17.72"],["1SG9_A_SAMA301_0","HEMK PROTEIN","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",5,"ILE A 836;GLY A 839;THR A 863;SER A 866;ASN A 910","None;SAH A1102 (-3.4A);None;None;SAH A1102 (-4.0A)","1.25A","1sg9A-6d6yA:12.1","1sg9A-6d6yA:undetectable"],["2F6D_A_ACRA996_1","GLUCOAMYLASE GLU1","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",4,"ASN A 807;ASP A 804;THR A 840;GLY A 841","None;None;SAH A1102 (-4.1A);None","0.96A","2f6dA-6d6yA:undetectable","2f6dA-6d6yA:11.45"],["2HC4_A_VDXA525_2","VITAMIN D RECEPTOR","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",4,"LEU A 711;LEU A 708;ARG A 702;TYR A 950","None","1.23A","2hc4A-6d6yA:undetectable","2hc4A-6d6yA:17.43"],["2Y7H_C_SAMC530_1","TYPE I RESTRICTION ENZYME ECOKI M PROTEIN","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",3,"TYR A 748;GLU A 659;ASN A 652","None","0.95A","2y7hC-6d6yA:2.9","2y7hC-6d6yA:undetectable"],["3H5G_B_LEIB16_0","COIL SER L16D-PEN","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",4,"LEU A 708;GLN A 686;LEU A 690;GLU A 687","None","1.02A","3h5gA-6d6yA:undetectable;3h5gB-6d6yA:undetectable","3h5gA-6d6yA:undetectable;3h5gB-6d6yA:undetectable"],["3JW3_A_TOPA208_1","DIHYDROFOLATE REDUCTASE","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",5,"ALA A 545;LEU A 570;LEU A 611;ILE A 559;THR A 542","None","1.08A","3jw3A-6d6yA:undetectable","3jw3A-6d6yA:18.54"],["3QL3_A_FOLA161_0","DIHYDROFOLATE REDUCTASE","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",5,"ALA A 512;ASP A 516;LEU A 555;ILE A 509;THR A 513","None","1.19A","3ql3A-6d6yA:undetectable","3ql3A-6d6yA:undetectable"],["3SGL_A_SAMA692_0","TRNA 5-METHYLAMINOMETHYL-2-THIOURIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN MNMC","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",5,"GLU A 835;GLY A 837;GLY A 839;THR A 840;ASP A 889","None;SAH A1102 (-3.5A);SAH A1102 (-3.4A);SAH A1102 (-4.1A);SAH A1102 (-3.5A)","0.65A","3sglA-6d6yA:6.5","3sglA-6d6yA:undetectable"],["3UFN_A_ROCA402_1","HIV-1 PROTEASE;HIV-1 PROTEASE","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",4,"ARG A 967;LEU A 978;VAL A 982;ASP A 963","None","1.13A","3ufnA-6d6yA:undetectable;3ufnB-6d6yA:undetectable","3ufnA-6d6yA:19.61;3ufnB-6d6yA:19.61"],["3UNA_A_SALA1340_1","XANTHINE DEHYDROGENASE\/OXIDASE","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",5,"LEU A 923;SER A 926;PHE A 988;LEU A 938;ALA A1013","None","1.22A","3unaA-6d6yA:undetectable","3unaA-6d6yA:4.58"],["3UNA_B_SALB1340_1","XANTHINE DEHYDROGENASE\/OXIDASE","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",5,"LEU A 923;SER A 926;PHE A 988;LEU A 938;ALA A1013","None","1.21A","3unaB-6d6yA:2.0","3unaB-6d6yA:4.58"],["3V4T_C_ACTC502_0","UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",3,"PRO A 964;ASP A 963;GLU A 962","None","0.70A","3v4tC-6d6yA:1.9","3v4tC-6d6yA:undetectable"],["4B17_A_SAMA1358_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE M","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",5,"GLY A 837;GLY A 841;GLY A 842;ASP A 864;ASP A 889","SAH A1102 (-3.5A);None;SAH A1102 ( 4.9A);SAH A1102 (-2.4A);SAH A1102 (-3.5A)","0.65A","4b17A-6d6yA:9.5","4b17A-6d6yA:undetectable"],["4BBO_B_ACTB1114_0","BLR5658 PROTEIN","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",3,"TRP A 626;TRP A 584;THR A 579","None","1.11A","4bboB-6d6yA:undetectable","4bboB-6d6yA:undetectable"],["4D7H_A_H4BA902_1","NITRIC OXIDE SYNTHASE OXYGENASE","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",3,"ARG A 967;THR A 942;TRP A 979","None","1.22A","4d7hA-6d6yA:undetectable","4d7hA-6d6yA:14.50"],["4E1G_B_LNLB701_2","PROSTAGLANDIN G\/H SYNTHASE 2","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",4,"TYR A 950;VAL A 763;LEU A 767;VAL A 742","None","0.88A","4e1gB-6d6yA:2.1","4e1gB-6d6yA:9.14"],["4EJJ_B_NCTB501_1","CYTOCHROME P450 2A6","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",4,"PHE A 793;VAL A 762;GLY A 952;PHE A 797","None","0.79A","4ejjB-6d6yA:undetectable","4ejjB-6d6yA:11.67"],["4FGZ_B_CQAB301_0","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",4,"GLY A 845;GLU A 835;LEU A 810;VAL A 814","None","0.89A","4fgzB-6d6yA:15.3","4fgzB-6d6yA:undetectable"],["4IV0_B_SAMB302_0","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE, PUTATIVE","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",5,"GLY A 837;GLY A 839;ILE A 865;ASP A 889;ILE A 890","SAH A1102 (-3.5A);SAH A1102 (-3.4A);SAH A1102 (-3.6A);SAH A1102 (-3.5A);SAH A1102 (-4.4A)","0.94A","4iv0B-6d6yA:15.2","4iv0B-6d6yA:undetectable"],["4IV8_A_SAMA301_0","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE,PUTATIVE","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",6,"GLY A 837;GLY A 839;ASP A 864;ILE A 865;ASP A 889;ILE A 890","SAH A1102 (-3.5A);SAH A1102 (-3.4A);SAH A1102 (-2.4A);SAH A1102 (-3.6A);SAH A1102 (-3.5A);SAH A1102 (-4.4A)","0.94A","4iv8A-6d6yA:15.4","4iv8A-6d6yA:undetectable"],["4IV8_B_SAMB301_0","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE,PUTATIVE","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",6,"GLY A 837;GLY A 839;ASP A 864;ILE A 865;ASP A 889;ILE A 890","SAH A1102 (-3.5A);SAH A1102 (-3.4A);SAH A1102 (-2.4A);SAH A1102 (-3.6A);SAH A1102 (-3.5A);SAH A1102 (-4.4A)","0.96A","4iv8B-6d6yA:15.3","4iv8B-6d6yA:undetectable"],["4KT0_A_PQNA2001_1","PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1;PHOTOSYSTEM I REACTION CENTER SUBUNIT IX","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",5,"PHE A 797;GLY A 842;GLY A 795;ILE A 773;LEU A 774","None;SAH A1102 ( 4.9A);None;None;None","1.06A","4kt0A-6d6yA:2.2;4kt0J-6d6yA:undetectable","4kt0A-6d6yA:7.88;4kt0J-6d6yA:20.00"],["4LTW_A_486A303_1","ANCESTRAL STEROID RECEPTOR 2","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",5,"LEU A 711;ALA A 665;LEU A 735;TYR A 770;LEU A 707","None","1.38A","4ltwA-6d6yA:undetectable","4ltwA-6d6yA:16.67"],["4M11_D_MXMD606_1","PROSTAGLANDIN G\/H SYNTHASE 2","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",5,"MET A 675;ILE A 696;LEU A 694;VAL A 724;LEU A 707","None","1.39A","4m11D-6d6yA:undetectable","4m11D-6d6yA:9.32"],["4P65_A_IPHA101_0","INSULIN","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",5,"LEU A 555;HIS A 546;ALA A 558;LEU A 539;LEU A 576","None","1.22A","4p65A-6d6yA:undetectable;4p65B-6d6yA:undetectable;4p65F-6d6yA:undetectable;4p65H-6d6yA:undetectable","4p65A-6d6yA:undetectable;4p65B-6d6yA:undetectable;4p65F-6d6yA:undetectable;4p65H-6d6yA:undetectable"],["4QDJ_A_SAMA301_0","MAGNESIUM-PROTOPORPHYRIN O-METHYLTRANSFERASE","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",5,"GLY A 837;GLY A 839;ILE A 865;SER A 866;VAL A 912","SAH A1102 (-3.5A);SAH A1102 (-3.4A);SAH A1102 (-3.6A);None;SAH A1102 ( 4.5A)","0.66A","4qdjA-6d6yA:14.9","4qdjA-6d6yA:undetectable"],["4RZV_A_032A801_1","SERINE\/THREONINE-PROTEIN KINASE B-RAF","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",5,"ALA A 545;LEU A 570;ILE A 559;THR A 561;GLY A 599","None","0.93A","4rzvA-6d6yA:undetectable","4rzvA-6d6yA:12.00"],["4UGL_A_H4BA902_1","NITRIC OXIDE SYNTHASE","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",3,"ARG A 967;THR A 942;TRP A 979","None","1.23A","4uglA-6d6yA:undetectable","4uglA-6d6yA:14.50"],["5BW4_A_SAMA301_0","16S RRNA (ADENINE(1408)-N(1))-METHYLTRANSFERASE","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",5,"GLY A 837;GLY A 839;THR A 844;ASP A 864;ILE A 890","SAH A1102 (-3.5A);SAH A1102 (-3.4A);None;SAH A1102 (-2.4A);SAH A1102 (-4.4A)","1.14A","5bw4A-6d6yA:12.4","5bw4A-6d6yA:undetectable"],["5DPD_A_SAMA601_0","PROTEIN LYSINE METHYLTRANSFERASE 1","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",5,"GLU A 835;GLY A 837;SER A 866;ILE A 890;VAL A 912","None;SAH A1102 (-3.5A);None;SAH A1102 (-4.4A);SAH A1102 ( 4.5A)","0.68A","5dpdA-6d6yA:14.0","5dpdA-6d6yA:undetectable"],["5DPD_B_SAMB601_0","PROTEIN LYSINE METHYLTRANSFERASE 1","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",5,"GLY A 837;ASP A 864;SER A 866;ILE A 890;VAL A 912","SAH A1102 (-3.5A);SAH A1102 (-2.4A);None;SAH A1102 (-4.4A);SAH A1102 ( 4.5A)","0.80A","5dpdB-6d6yA:14.1","5dpdB-6d6yA:undetectable"],["5G6C_A_H4BA902_1","NITRIC OXIDE SYNTHASE OXYGENASE","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",3,"ARG A 967;THR A 942;TRP A 979","None","1.23A","5g6cA-6d6yA:undetectable","5g6cA-6d6yA:14.50"],["5HG0_A_SAMA301_0","PANTOTHENATE SYNTHETASE","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",5,"GLY A 957;LEU A 960;VAL A 982;GLN A 956;LEU A 955","None","1.22A","5hg0A-6d6yA:undetectable","5hg0A-6d6yA:undetectable"],["5KB5_A_ADNA401_2","ADENOSINE KINASE","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",4,"ASN A 931;LEU A 930;SER A 903;LEU A 834","None","1.37A","5kb5A-6d6yA:4.0","5kb5A-6d6yA:13.86"],["6BP4_A_SAMA505_1","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-9 SPECIFIC","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",3,"ILE A1011;ASN A 911;CYH A 972","None","0.92A","6bp4A-6d6yA:undetectable","6bp4A-6d6yA:undetectable"],["6CK2_C_IPHC101_0","INSULIN A CHAIN;INSULIN B CHAIN","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",4,"ILE A 517;LEU A 555;HIS A 546;ALA A 558","None","0.80A","6ck2C-6d6yA:undetectable;6ck2D-6d6yA:undetectable","6ck2C-6d6yA:undetectable;6ck2D-6d6yA:undetectable"],["6ECT_A_SAMA1300_1","STIE PROTEIN","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",4,"THR A 786;ARG A 765;THR A 840;ASP A 864","None;None;SAH A1102 (-4.1A);SAH A1102 (-2.4A)","1.40A","6ectA-6d6yA:14.3","6ectA-6d6yA:undetectable"],["6ECX_A_SAMA1301_1","STIE PROTEIN","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",4,"THR A 786;ARG A 765;THR A 840;ASP A 864","None;None;SAH A1102 (-4.1A);SAH A1102 (-2.4A)","1.35A","6ecxA-6d6yA:14.1","6ecxA-6d6yA:undetectable"],["6HUO_D_08HD501_0","GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",4,"ASN A 781;PHE A 785;VAL A 868;TYR A 872","None","1.18A","6huoC-6d6yA:3.3;6huoD-6d6yA:undetectable","6huoC-6d6yA:23.16;6huoD-6d6yA:19.35"],["6IFT_A_SAMA301_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE A","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",5,"GLU A 835;ILE A 836;GLY A 837;GLY A 839;ILE A 865","None;None;SAH A1102 (-3.5A);SAH A1102 (-3.4A);SAH A1102 (-3.6A)","0.52A","6iftA-6d6yA:9.3","6iftA-6d6yA:undetectable"],["6J20_A_GBQA1201_1","SUBSTANCE-P RECEPTOR,ENDOLYSIN","6d6y","APRA METHYLTRANSFERASE 2","Moorea bouillonii",4,"ILE A 831;TRP A 882;HIS A 854;VAL A 818","None","1.07A","6j20A-6d6yA:undetectable","6j20A-6d6yA:undetectable"]]