SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d72'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 6d72 SPERMIDINE
N1-ACETYLTRANSFERASE
(Yersinia
pestis) 		5 / 12 ALA A 100
TYR A 135
VAL A 124
GLY A 101
ILE A 134
 None
 1.37A 2dcfA-6d72A:
undetectable		 2dcfA-6d72A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 6d72 SPERMIDINE
N1-ACETYLTRANSFERASE
(Yersinia
pestis) 		4 / 7 ASP A  16
LEU A  12
GLN A  22
ARG A  10
 None
 1.07A 2qqcG-6d72A:
undetectable
2qqcJ-6d72A:
undetectable		 2qqcG-6d72A:
23.17
2qqcJ-6d72A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 6d72 SPERMIDINE
N1-ACETYLTRANSFERASE
(Yersinia
pestis) 		5 / 12 ILE A  62
ALA A 102
VAL A 114
LEU A   9
LEU A 120
 None
 1.15A 2rctA-6d72A:
undetectable		 2rctA-6d72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 6d72 SPERMIDINE
N1-ACETYLTRANSFERASE
(Yersinia
pestis) 		5 / 11 LEU A 120
ALA A 104
ALA A 107
LEU A 115
PHE A 140
 None
 1.20A 3bszE-6d72A:
undetectable		 3bszE-6d72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 6d72 SPERMIDINE
N1-ACETYLTRANSFERASE
(Yersinia
pestis) 		4 / 8 GLU A 109
TYR A 110
PHE A  60
ILE A  62
 None
 1.09A 3jz0B-6d72A:
undetectable		 3jz0B-6d72A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 6d72 SPERMIDINE
N1-ACETYLTRANSFERASE
(Yersinia
pestis) 		4 / 6 HIS A  51
GLU A  57
ASP A  54
SER A  56
 None
PEG  A 203 (-2.7A)
None
None
 1.18A 4apjA-6d72A:
undetectable
4apjP-6d72A:
undetectable		 4apjA-6d72A:
undetectable
4apjP-6d72A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 6d72 SPERMIDINE
N1-ACETYLTRANSFERASE
(Yersinia
pestis) 		4 / 8 GLU A  76
GLU A  85
ILE A  88
LEU A 122
 CA  A 201 ( 2.4A)
MLI  A 204 ( 4.6A)
None
None
 0.58A 4mj8A-6d72A:
23.3		 4mj8A-6d72A:
62.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 6d72 SPERMIDINE
N1-ACETYLTRANSFERASE
(Yersinia
pestis) 		5 / 12 ILE A  62
ALA A 102
VAL A 114
LEU A   9
LEU A 120
 None
 1.27A 4qynA-6d72A:
undetectable		 4qynA-6d72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 6d72 SPERMIDINE
N1-ACETYLTRANSFERASE
(Yersinia
pestis) 		5 / 12 ILE A  62
ALA A 102
VAL A 114
LEU A   9
LEU A 120
 None
 1.19A 4qzuC-6d72A:
undetectable		 4qzuC-6d72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 6d72 SPERMIDINE
N1-ACETYLTRANSFERASE
(Yersinia
pestis) 		3 / 3 VAL A   7
TYR A  99
ALA A 102
 None
 0.35A 4ybnA-6d72A:
undetectable		 4ybnA-6d72A:
undetectable