SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d7a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 6d7a PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		5 / 12 VAL A 944
LEU A 861
PHE A 940
PHE A 954
MET A1039
 None
 1.35A 1fdsA-6d7aA:
undetectable		 1fdsA-6d7aA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 6d7a PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		4 / 4 HIS A1074
ALA A1006
PHE A1071
GLY A1004
 None
 1.28A 1mj2B-6d7aA:
undetectable		 1mj2B-6d7aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 6d7a PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		4 / 4 HIS A1074
ALA A1006
PHE A1071
GLY A1004
 None
 1.21A 1mj2D-6d7aA:
undetectable		 1mj2D-6d7aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 6d7a PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		4 / 4 HIS A1074
ALA A1006
PHE A1071
GLY A1004
 None
 1.25A 1mjoB-6d7aA:
undetectable		 1mjoB-6d7aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 6d7a PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		4 / 4 HIS A1074
ALA A1006
PHE A1071
GLY A1004
 None
 1.27A 1mjoD-6d7aA:
undetectable		 1mjoD-6d7aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 6d7a PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		5 / 9 THR A 961
LEU A 991
LEU A 825
GLY A 990
VAL A1028
 None
 1.42A 4c9kA-6d7aA:
undetectable		 4c9kA-6d7aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 6d7a PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		3 / 3 ASN A 862
SER A 891
SER A 890
 None
 0.78A 5gsnA-6d7aA:
undetectable		 5gsnA-6d7aA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 6d7a PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		4 / 7 THR A 971
ARG A1073
HIS A1036
ASP A 952
 None
 1.11A 6mn4E-6d7aA:
undetectable		 6mn4E-6d7aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 6d7a PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		4 / 7 THR A 971
ARG A1073
HIS A1074
ASP A 952
 None
 1.29A 6mn4E-6d7aA:
undetectable		 6mn4E-6d7aA:
undetectable